MTAP_YEAST - dbPTM
MTAP_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTAP_YEAST
UniProt AC Q07938
Protein Name S-methyl-5'-thioadenosine phosphorylase {ECO:0000255|HAMAP-Rule:MF_03155}
Gene Name MEU1 {ECO:0000255|HAMAP-Rule:MF_03155}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 337
Subcellular Localization Cytoplasm. Nucleus.
Protein Description Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. Seems to be implicated in the regulation of the expression of the ADH2 gene..
Protein Sequence MNRIKNTFSVAKRLKLSKVMTNSELPSIFEGTVDLGIIGGTGLYNLDCLEPIALLPPMVTPWGTTSSPVTISQFVGTNSHFHVAFIARHGINHEYPPTKVPFRANMAALKNLNCKAVLSFSAVGSLQPHIKPRDFVLPQQIIDRTKGIRHSSYFNDEGLVGHVGFGQPFSQKFAEYIYQFKNEITNPESEEPCHLHYDKDMTVVCMEGPQFSTRAESKMYRMFGGHVINMSVIPEAKLARECELPYQMICMSTDYDAWRDEAEPVTVETVIGNLTNNGRNANILASKIIVSMAKEIPEFMHTGDGLRGSIKKSISTKPEAMSKETLERLRYLFPNYW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
131AcetylationGSLQPHIKPRDFVLP
CCCCCCCCCCCCCCC		30.8524489116
237UbiquitinationMSVIPEAKLARECEL
EECCCHHHHHHCCCC		40.8023749301
237AcetylationMSVIPEAKLARECEL
EECCCHHHHHHCCCC		40.8024489116
246PhosphorylationARECELPYQMICMST
HHCCCCCEEEEEECC		24.2827017623
252PhosphorylationPYQMICMSTDYDAWR
CEEEEEECCCHHHHH		17.4527017623
255PhosphorylationMICMSTDYDAWRDEA
EEEECCCHHHHHCCC		13.9827017623
287UbiquitinationNANILASKIIVSMAK
CHHHHHHHHHHHHHH		30.7417644757
294UbiquitinationKIIVSMAKEIPEFMH
HHHHHHHHHCHHHHH		47.7517644757
313PhosphorylationLRGSIKKSISTKPEA
CCHHHHHHCCCCCCC		19.4419779198
317AcetylationIKKSISTKPEAMSKE
HHHHCCCCCCCCCHH		33.7922865919
322PhosphorylationSTKPEAMSKETLERL
CCCCCCCCHHHHHHH		34.0919823750
323AcetylationTKPEAMSKETLERLR
CCCCCCCHHHHHHHH		41.4524489116
325PhosphorylationPEAMSKETLERLRYL
CCCCCHHHHHHHHHH		37.3419823750
331PhosphorylationETLERLRYLFPNYW-
HHHHHHHHHCCCCC-		19.7919823750
336PhosphorylationLRYLFPNYW------
HHHHCCCCC------		16.8419823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTAP_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTAP_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTAP_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DCAM_YEASTSPE2genetic
16530730
VAM7_YEASTVAM7genetic
20093466
SYG1_YEASTSYG1genetic
20093466
YJY1_YEASTYJR011Cgenetic
20093466
EF1G2_YEASTTEF4genetic
20093466
TIR2_YEASTTIR2genetic
20093466
ADK_YEASTADO1genetic
21623372
RL6B_YEASTRPL6Bgenetic
27708008
TECR_YEASTTSC13genetic
27708008
NHP2_YEASTNHP2genetic
27708008
CDC1_YEASTCDC1genetic
27708008
PSB3_YEASTPUP3genetic
27708008
CDC4_YEASTCDC4genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
RPN11_YEASTRPN11genetic
27708008
SAD1_YEASTSAD1genetic
27708008
CDC20_YEASTCDC20genetic
27708008
GPI10_YEASTGPI10genetic
27708008
MED6_YEASTMED6genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
FNTA_YEASTRAM2genetic
27708008
NTR2_YEASTNTR2genetic
27708008
SEC39_YEASTSEC39genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
DBP6_YEASTDBP6genetic
27708008
NUF2_YEASTNUF2genetic
27708008
TYSY_YEASTCDC21genetic
27708008
ESA1_YEASTESA1genetic
27708008
APC5_YEASTAPC5genetic
27708008
GPI2_YEASTGPI2genetic
27708008
TBF1_YEASTTBF1genetic
27708008
HRR25_YEASTHRR25genetic
27708008
DIB1_YEASTDIB1genetic
27708008
ORC4_YEASTORC4genetic
27708008
PRP4_YEASTPRP4genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
SLX5_YEASTSLX5genetic
27708008
MED5_YEASTNUT1genetic
27708008
ELP2_YEASTELP2genetic
27708008
PTH_YEASTPTH1genetic
27708008
ILM1_YEASTILM1genetic
27708008
VPH1_YEASTVPH1genetic
27708008
YP245_YEASTYPL245Wgenetic
27708008
PP12_YEASTGLC7genetic
27453043
SCH9_YEASTSCH9genetic
27453043
BUB1_YEASTBUB1genetic
27453043
CDC42_YEASTCDC42genetic
27453043
VPS75_YEASTVPS75genetic
27453043
ERG26_YEASTERG26genetic
27453043
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTAP_YEAST

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Related Literatures of Post-Translational Modification

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