| UniProt ID | FNTA_YEAST | |
|---|---|---|
| UniProt AC | P29703 | |
| Protein Name | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | |
| Gene Name | RAM2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 316 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate.. | |
| Protein Sequence | MEEYDYSDVKPLPIETDLQDELCRIMYTEDYKRLMGLARALISLNELSPRALQLTAEIIDVAPAFYTIWNYRFNIVRHMMSESEDTVLYLNKELDWLDEVTLNNPKNYQIWSYRQSLLKLHPSPSFKRELPILKLMIDDDSKNYHVWSYRKWCCLFFSDFQHELAYASDLIETDIYNNSAWTHRMFYWVNAKDVISKVELADELQFIMDKIQLVPQNISPWTYLRGFQELFHDRLQWDSKVVDFATTFIGDVLSLPIGSPEDLPEIESSYALEFLAYHWGADPCTRDNAVKAYSLLAIKYDPIRKNLWHHKINNLN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of FNTA_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FNTA_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FNTA_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FNTA_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RDR1_YEAST | RDR1 | physical | 18719252 | |
| MED7_YEAST | MED7 | physical | 18719252 | |
| FNTB_YEAST | RAM1 | physical | 18719252 | |
| PGTB1_YEAST | CDC43 | physical | 20826334 | |
| PGTB1_YEAST | CDC43 | genetic | 23891562 | |
| SMI1_YEAST | SMI1 | genetic | 23891562 | |
| GUP1_YEAST | GUP1 | genetic | 23891562 | |
| CHS5_YEAST | CHS5 | genetic | 23891562 | |
| SRO7_YEAST | SRO7 | genetic | 23891562 | |
| HMCS_YEAST | ERG13 | genetic | 23891562 | |
| THIL_YEAST | ERG10 | genetic | 23891562 | |
| CDC24_YEAST | CDC24 | genetic | 23891562 | |
| TPM1_YEAST | TPM1 | genetic | 23891562 | |
| ICE2_YEAST | ICE2 | genetic | 23891562 | |
| PSB1_YEAST | PRE3 | genetic | 23891562 | |
| HMDH1_YEAST | HMG1 | genetic | 23891562 | |
| CCD33_HUMAN | CCDC33 | physical | 27107014 | |
| GAK_HUMAN | GAK | physical | 27107014 | |
| SPERT_HUMAN | SPERT | physical | 27107014 | |
| TNIP1_HUMAN | TNIP1 | physical | 27107014 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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