| UniProt ID | THIL_YEAST | |
|---|---|---|
| UniProt AC | P41338 | |
| Protein Name | Acetyl-CoA acetyltransferase | |
| Gene Name | ERG10 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 398 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Catalyzes the formation of acetoacetyl-CoA in the biosynthesis of mevalonate, an intermediate required for the biosynthesis of sterols and nonsterol isoprenoids.. | |
| Protein Sequence | MSQNVYIVSTARTPIGSFQGSLSSKTAVELGAVALKGALAKVPELDASKDFDEIIFGNVLSANLGQAPARQVALAAGLSNHIVASTVNKVCASAMKAIILGAQSIKCGNADVVVAGGCESMTNAPYYMPAARAGAKFGQTVLVDGVERDGLNDAYDGLAMGVHAEKCARDWDITREQQDNFAIESYQKSQKSQKEGKFDNEIVPVTIKGFRGKPDTQVTKDEEPARLHVEKLRSARTVFQKENGTVTAANASPINDGAAAVILVSEKVLKEKNLKPLAIIKGWGEAAHQPADFTWAPSLAVPKALKHAGIEDINSVDYFEFNEAFSVVGLVNTKILKLDPSKVNVYGGAVALGHPLGCSGARVVVTLLSILQQEGGKIGVAAICNGGGGASSIVIEKI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSQNVYIVS ------CCCCEEEEE | 30.38 | 22814378 | |
| 2 | Phosphorylation | ------MSQNVYIVS ------CCCCEEEEE | 30.38 | 28889911 | |
| 6 | Phosphorylation | --MSQNVYIVSTART --CCCCEEEEEECCC | 11.80 | 28889911 | |
| 9 | Phosphorylation | SQNVYIVSTARTPIG CCCEEEEEECCCCCC | 13.54 | 28889911 | |
| 10 | Phosphorylation | QNVYIVSTARTPIGS CCEEEEEECCCCCCC | 14.84 | 28889911 | |
| 17 | Phosphorylation | TARTPIGSFQGSLSS ECCCCCCCCCCCCCC | 18.34 | 22369663 | |
| 21 | Phosphorylation | PIGSFQGSLSSKTAV CCCCCCCCCCCCCHH | 17.81 | 22369663 | |
| 23 | Phosphorylation | GSFQGSLSSKTAVEL CCCCCCCCCCCHHHH | 31.33 | 22369663 | |
| 24 | Phosphorylation | SFQGSLSSKTAVELG CCCCCCCCCCHHHHH | 39.04 | 22369663 | |
| 25 | Ubiquitination | FQGSLSSKTAVELGA CCCCCCCCCHHHHHH | 36.81 | 23749301 | |
| 36 | Acetylation | ELGAVALKGALAKVP HHHHHHHHHHHHCCC | 32.19 | 24489116 | |
| 36 | Ubiquitination | ELGAVALKGALAKVP HHHHHHHHHHHHCCC | 32.19 | 24961812 | |
| 41 | Acetylation | ALKGALAKVPELDAS HHHHHHHCCCCCCCC | 60.20 | 24489116 | |
| 79 | Phosphorylation | VALAAGLSNHIVAST HHHHHHCCCHHHHHH | 25.99 | 29688323 | |
| 85 | Phosphorylation | LSNHIVASTVNKVCA CCCHHHHHHHHHHHH | 23.22 | 29688323 | |
| 86 | Phosphorylation | SNHIVASTVNKVCAS CCHHHHHHHHHHHHH | 20.54 | 29688323 | |
| 96 | Acetylation | KVCASAMKAIILGAQ HHHHHHHHHHHHCCC | 35.83 | 24489116 | |
| 136 | Acetylation | PAARAGAKFGQTVLV CHHHHCCCCCCEEEE | 49.46 | 24489116 | |
| 140 | Phosphorylation | AGAKFGQTVLVDGVE HCCCCCCEEEECCCC | 19.04 | 22369663 | |
| 155 | Phosphorylation | RDGLNDAYDGLAMGV CCCCCHHHCCCCCCC | 17.26 | 24909858 | |
| 166 | Acetylation | AMGVHAEKCARDWDI CCCCCHHHHHCCCCC | 33.70 | 24489116 | |
| 188 | Acetylation | FAIESYQKSQKSQKE HHHHHHHHHHHHHCC | 46.77 | 24489116 | |
| 194 | Acetylation | QKSQKSQKEGKFDNE HHHHHHHCCCCCCCC | 75.44 | 24489116 | |
| 197 | Acetylation | QKSQKEGKFDNEIVP HHHHCCCCCCCCEEE | 51.11 | 24489116 | |
| 197 | Ubiquitination | QKSQKEGKFDNEIVP HHHHCCCCCCCCEEE | 51.11 | 23749301 | |
| 208 | Acetylation | EIVPVTIKGFRGKPD CEEECEEECCCCCCC | 42.50 | 24489116 | |
| 216 | Phosphorylation | GFRGKPDTQVTKDEE CCCCCCCCCCCCCCC | 33.20 | 22369663 | |
| 219 | Phosphorylation | GKPDTQVTKDEEPAR CCCCCCCCCCCCCHH | 23.98 | 22369663 | |
| 220 | Acetylation | KPDTQVTKDEEPARL CCCCCCCCCCCCHHH | 65.37 | 24489116 | |
| 231 | Acetylation | PARLHVEKLRSARTV CHHHHHHHHHHCCEE | 48.38 | 24489116 | |
| 241 | Acetylation | SARTVFQKENGTVTA HCCEEEEECCCCEEE | 41.50 | 24489116 | |
| 267 | Acetylation | AVILVSEKVLKEKNL EEEEEEHHHHHHCCC | 45.41 | 24489116 | |
| 275 | Succinylation | VLKEKNLKPLAIIKG HHHHCCCCCEEEEEC | 47.59 | 23954790 | |
| 275 | Acetylation | VLKEKNLKPLAIIKG HHHHCCCCCEEEEEC | 47.59 | 24489116 | |
| 281 | Acetylation | LKPLAIIKGWGEAAH CCCEEEEECCHHHHC | 42.36 | 24489116 | |
| 337 | Acetylation | LVNTKILKLDPSKVN EEECEEEECCHHHEE | 55.08 | 24489116 | |
| 337 | Succinylation | LVNTKILKLDPSKVN EEECEEEECCHHHEE | 55.08 | 23954790 | |
| 342 | Acetylation | ILKLDPSKVNVYGGA EEECCHHHEEEECCC | 43.12 | 24489116 | |
| 342 | Ubiquitination | ILKLDPSKVNVYGGA EEECCHHHEEEECCC | 43.12 | 23749301 | |
| 397 | Ubiquitination | ASSIVIEKI------ CCCEEEEEC------ | 42.46 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of THIL_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of THIL_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of THIL_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND MASSSPECTROMETRY. | |
