BCH1_YEAST - dbPTM
BCH1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BCH1_YEAST
UniProt AC Q05029
Protein Name Protein BCH1
Gene Name BCH1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 724
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein . Trans-Golgi network location requires interaction with CHS5 and with myristoylated GTP-bound ARF1 for the recruitment to the membranes.
Protein Description Member of the CHS5-ARF1P-binding proteins (CHAPS) which mediates export of specific cargo proteins, including chitin synthase CHS3..
Protein Sequence MLSQTSIPEVKEDVIGYALHQRRARVGQFQDLGPPDLITLIKSLPSSSSTTTATASANDNGATSNINGQDPTTIVTELHSHDKLKGQIGTFFYCMGIDTSDPTSITIFAKKITDLFLDTPQIWFGKKKHFHVSKISISSWNAFRKYDVNIIVHIPGTVQTYIINSDGEQSQLPSVAEASSGRNSQDLNVNMIWAETFMSGIVRDIMIMKDNRADGESQNLVETLIFNPFTSGELEDVANNFIKLFPLVYEKGVYLDAPTHVLNPSLTNNYLVETLVEIVRLTKSLEACRKMLKKLIEIHPEAVIILIRVYFACDLEIDAVDLINEQLNSPSSFLADDSKTSHIQLIFKSELLSIQSEFLLDVKRDYKLAKEVAMEAVNCAPNEFKTWYLLTRIYIKLNDMSNALLSLNACPMSQVKEKYVLRRIAPITSDENLHLPLPLDASIEEISSLNPMDVQLEQKSADPNLVNLSASSLKSTFQLAYKLLTEIVQITGWEQLLKYRSKIFVMEDEYQGSTSSIDEAEVRGNDISKMRSKRLCERWLDNLFMLLYEDLKTYTDWQSEQLYFDAQNSKYHKLTVEWELFGLCAKRLGHLPEAAKAFQIGLSQRFSPVCAKNLLQFYIDEHKRIRRDSVSANSELTSSQILSSINDIDSSIIDLVVKICCWNHRWYIEFSIILIDALSVAVQDMGITKVHNEIASRFSDPVAQLIDDNILNFLKNFTNDTFDN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MLSQTSIPEV
-----CCCCCCCHHH		30.0721551504
42UbiquitinationPDLITLIKSLPSSSS
HHHHHHHHCCCCCCC		49.4017644757
83AcetylationTELHSHDKLKGQIGT
EEEECCHHHCCCEEE		46.8324489116
126AcetylationTPQIWFGKKKHFHVS
CCCEECCCCCCEEEE		49.5324489116
370UbiquitinationKRDYKLAKEVAMEAV
HHHHHHHHHHHHHHH		64.2623749301
510PhosphorylationIFVMEDEYQGSTSSI
EEEEECCCCCCCCCC		30.4222369663
513PhosphorylationMEDEYQGSTSSIDEA
EECCCCCCCCCCCHH		15.0222369663
514PhosphorylationEDEYQGSTSSIDEAE
ECCCCCCCCCCCHHH		33.0620377248
515PhosphorylationDEYQGSTSSIDEAEV
CCCCCCCCCCCHHHH		27.3022369663
516PhosphorylationEYQGSTSSIDEAEVR
CCCCCCCCCCHHHHC		33.8622369663
528PhosphorylationEVRGNDISKMRSKRL
HHCCCHHHHHHHHHH		24.2219823750
553PhosphorylationLLYEDLKTYTDWQSE
HHHHHHHHHCCCCCC		38.6628132839
554PhosphorylationLYEDLKTYTDWQSEQ
HHHHHHHHCCCCCCE		10.9125882841
555PhosphorylationYEDLKTYTDWQSEQL
HHHHHHHCCCCCCEE		35.6725882841
623AcetylationQFYIDEHKRIRRDSV
HHHHHHHCCCCCCCC		47.6924489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BCH1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BCH1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BCH1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YRA1_YEASTYRA1physical
16554755
ADH1_YEASTADH1physical
16429126
CHS5_YEASTCHS5physical
16429126
RL5_YEASTRPL5physical
16429126
HSP72_YEASTSSA2physical
19536198
BUD7_YEASTBUD7genetic
19812245
BCH2_YEASTBCH2genetic
19812245
CHS6_YEASTCHS6genetic
19812245
AP1B1_YEASTAPL2genetic
19812245
BCH1_YEASTBCH1physical
22940862
CHS6_YEASTCHS6physical
23015758
SNF5_YEASTSNF5genetic
27708008
DAL81_YEASTDAL81genetic
27708008
ATC3_YEASTDRS2genetic
27708008
ETR1_YEASTETR1genetic
27708008
MCFS2_YEASTEHT1genetic
27708008
YCR3_YEASTYCR023Cgenetic
27708008
NHP10_YEASTNHP10genetic
27708008
RPN4_YEASTRPN4genetic
27708008
GPR1_YEASTGPR1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
AAD4_YEASTAAD4genetic
27708008
MNN10_YEASTMNN10genetic
27708008
YSP2_YEASTYSP2genetic
27708008
DOT1_YEASTDOT1genetic
27708008
PUF6_YEASTPUF6genetic
27708008
YFF1_YEASTYFL051Cgenetic
27708008
SA155_YEASTSAP155genetic
27708008
CUE3_YEASTCUE3genetic
27708008
MON1_YEASTMON1genetic
27708008
MNT2_YEASTMNT2genetic
27708008
YG5Q_YEASTYGR273Cgenetic
27708008
SPO13_YEASTSPO13genetic
27708008
HTD2_YEASTHTD2genetic
27708008
PP2C7_YEASTPTC7genetic
27708008
LAM1_YEASTYSP1genetic
27708008
AIR1_YEASTAIR1genetic
27708008
DENR_YEASTTMA22genetic
27708008
ELM1_YEASTELM1genetic
27708008
FABG_YEASTOAR1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
SAC1_YEASTSAC1genetic
27708008
RHO4_YEASTRHO4genetic
27708008
SRN2_YEASTSRN2genetic
27708008
YL225_YEASTYLR225Cgenetic
27708008
TSR2_YEASTTSR2genetic
27708008
FAP1_YEASTFAP1genetic
27708008
ATG3_YEASTATG3genetic
27708008
BUD21_YEASTBUD21genetic
27708008
VPS21_YEASTVPS21genetic
27708008
RAD1_YEASTRAD1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
BEM4_YEASTBEM4genetic
27708008
YP015_YEASTYPR015Cgenetic
27708008
ASR1_YEASTASR1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BCH1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-513 AND SER-516, ANDMASS SPECTROMETRY.

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