RHO4_YEAST - dbPTM
RHO4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHO4_YEAST
UniProt AC Q00246
Protein Name GTP-binding protein RHO4
Gene Name RHO4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 291
Subcellular Localization Cell membrane
Lipid-anchor
Cytoplasmic side .
Protein Description Plays an important role in cell growth. Required to keep the uninucleated state. May be involved in the organization of the cytoskeleton which affects microtubule functions. Most likely RHO3 and RHO4 of S.cerevisiae regulate partially overlapping but different pathways..
Protein Sequence MNTLLFKRKGGNCGNESNIVSQGSPSSSNLPESPGTLDEKNLPRLPTPFARSLSTIPSYEQMKRTNKLPDYHLKIVVVGDGAVGKTCLLISYVQGTFPTDYIPTIFENYVTNIEGPNGQIIELALWDTAGQEEYSRLRPLSYTNADVLMVCYSVGSKTSLKNVEDLWFPEVKHFCPSTPIMLVGLKSDLYEADNLSDLVEPSSAESLAKRLGAFAHIQCSARLKENIDEVFETAIHTLLSDSLYAPREPTHTIKNPFKRNTTRSDIDSSTGDTSVSISGTKRLRKNKCIIM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationGNESNIVSQGSPSSS
CCCCCCCCCCCCCCC		25.6527017623
24PhosphorylationSNIVSQGSPSSSNLP
CCCCCCCCCCCCCCC		17.6121440633
26PhosphorylationIVSQGSPSSSNLPES
CCCCCCCCCCCCCCC		48.3621440633
27PhosphorylationVSQGSPSSSNLPESP
CCCCCCCCCCCCCCC		26.9921440633
28PhosphorylationSQGSPSSSNLPESPG
CCCCCCCCCCCCCCC		46.8827017623
33PhosphorylationSSSNLPESPGTLDEK
CCCCCCCCCCCCCCC		27.0423749301
36PhosphorylationNLPESPGTLDEKNLP
CCCCCCCCCCCCCCC		34.1321440633
40UbiquitinationSPGTLDEKNLPRLPT
CCCCCCCCCCCCCCC		64.5523749301
47PhosphorylationKNLPRLPTPFARSLS
CCCCCCCCCCHHHHC		35.3119823750
52PhosphorylationLPTPFARSLSTIPSY
CCCCCHHHHCCCCCH		24.2022369663
54PhosphorylationTPFARSLSTIPSYEQ
CCCHHHHCCCCCHHH		26.0722369663
55PhosphorylationPFARSLSTIPSYEQM
CCHHHHCCCCCHHHH		42.0522369663
58PhosphorylationRSLSTIPSYEQMKRT
HHHCCCCCHHHHHHH		37.1322369663
59PhosphorylationSLSTIPSYEQMKRTN
HHCCCCCHHHHHHHC		12.5822369663
187PhosphorylationIMLVGLKSDLYEADN
EEEEEECCCCCCCCC		37.5822369663
190PhosphorylationVGLKSDLYEADNLSD
EEECCCCCCCCCHHH		17.6723749301
196PhosphorylationLYEADNLSDLVEPSS
CCCCCCHHHHCCCCC		34.8422369663
202PhosphorylationLSDLVEPSSAESLAK
HHHHCCCCCHHHHHH		28.7722369663
203PhosphorylationSDLVEPSSAESLAKR
HHHCCCCCHHHHHHH		46.9322369663
206PhosphorylationVEPSSAESLAKRLGA
CCCCCHHHHHHHHCH		33.0922369663
261PhosphorylationKNPFKRNTTRSDIDS
CCCCCCCCCHHHCCC		27.8528889911
262PhosphorylationNPFKRNTTRSDIDSS
CCCCCCCCHHHCCCC		31.5521440633
264PhosphorylationFKRNTTRSDIDSSTG
CCCCCCHHHCCCCCC		36.5022369663
268PhosphorylationTTRSDIDSSTGDTSV
CCHHHCCCCCCCEEE		30.0822369663
269PhosphorylationTRSDIDSSTGDTSVS
CHHHCCCCCCCEEEE		32.4422369663
270PhosphorylationRSDIDSSTGDTSVSI
HHHCCCCCCCEEEEE		42.9222369663
273PhosphorylationIDSSTGDTSVSISGT
CCCCCCCEEEEECCC		32.1628889911
274PhosphorylationDSSTGDTSVSISGTK
CCCCCCEEEEECCCC		20.7128889911
276PhosphorylationSTGDTSVSISGTKRL
CCCCEEEEECCCCCC		15.7124961812
278PhosphorylationGDTSVSISGTKRLRK
CCEEEEECCCCCCCC		32.6728889911
288FarnesylationKRLRKNKCIIM----
CCCCCCCEEEC----		3.40-
288MethylationKRLRKNKCIIM----
CCCCCCCEEEC----		3.40-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHO4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHO4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHO4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PYRD_YEASTURA1physical
11805837
BEM4_YEASTBEM4physical
10688190
BNR1_YEASTBNR1physical
9184220
BEM4_YEASTBEM4physical
8754839
BEM4_YEASTBEM4physical
11489916
PSMD9_YEASTNAS2physical
11489916
CDC42_YEASTCDC42genetic
12810699
EXO70_YEASTEXO70physical
19955214
RCR1_YEASTRCR1genetic
20093466
SIF2_YEASTSIF2genetic
20093466
AGP2_YEASTAGP2genetic
20093466
MBA1_YEASTMBA1genetic
20093466
HPC2_YEASTHPC2genetic
20093466
RBSK_YEASTRBK1genetic
20093466
QRI7_YEASTQRI7genetic
20093466
OMS1_YEASTOMS1genetic
20093466
FKBP2_YEASTFPR2genetic
20093466
MEI4_YEASTMEI4genetic
20093466
GCN20_YEASTGCN20genetic
20093466
PHB1_YEASTPHB1genetic
20093466
TBP7_YEASTYTA7genetic
20093466
ERV29_YEASTERV29genetic
20093466
PTH_YEASTPTH1genetic
20093466
IST3_YEASTIST3genetic
20093466
TAX4_YEASTTAX4genetic
20093466
DLS1_YEASTDLS1genetic
20093466
RL8B_YEASTRPL8Bgenetic
20093466
SIC1_YEASTSIC1genetic
20093466
ARP6_YEASTARP6genetic
20093466
PEX13_YEASTPEX13genetic
20093466
AMPD_YEASTAMD1genetic
20093466
GBLP_YEASTASC1genetic
20093466
MAS5_YEASTYDJ1genetic
20093466
COX5A_YEASTCOX5Agenetic
20093466
MSH2_YEASTMSH2genetic
20093466
AIM39_YEASTAIM39genetic
20093466
CY1_YEASTCYT1genetic
20093466
CARP_YEASTPEP4genetic
20093466
ELP4_YEASTELP4genetic
20093466
CISY3_YEASTCIT3genetic
20093466
CHMU_YEASTARO7genetic
20093466
SUE1_YEASTSUE1genetic
20093466
QCR2_YEASTQCR2genetic
20093466
CDC42_YEASTCDC42genetic
1448099
BEM1_YEASTBEM1genetic
1448099
TOS2_YEASTTOS2genetic
21143383
BNI1_YEASTBNI1genetic
12810699
BNR1_YEASTBNR1genetic
12810699
BEM2_YEASTBEM2physical
23264647
PRP6_YEASTPRP6genetic
27708008
ACT_YEASTACT1genetic
27708008
MED6_YEASTMED6genetic
27708008
CDC12_YEASTCDC12genetic
27708008
PRP19_YEASTPRP19genetic
27708008
SEC22_YEASTSEC22genetic
27708008
DCP2_YEASTDCP2genetic
27708008
NAB3_YEASTNAB3genetic
27708008
NU170_YEASTNUP170genetic
27708008
RCR1_YEASTRCR1genetic
27708008
AGP2_YEASTAGP2genetic
27708008
AGP1_YEASTAGP1genetic
27708008
RBSK_YEASTRBK1genetic
27708008
MTU1_YEASTSLM3genetic
27708008
GPR1_YEASTGPR1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
QRI7_YEASTQRI7genetic
27708008
ARO1_YEASTARO1genetic
27708008
H2A1_YEASTHTA1genetic
27708008
RT103_YEASTRTT103genetic
27708008
IPK1_YEASTIPK1genetic
27708008
OMS1_YEASTOMS1genetic
27708008
SNF1_YEASTSNF1genetic
27708008
FKBP2_YEASTFPR2genetic
27708008
FIT1_YEASTFIT1genetic
27708008
MEI4_YEASTMEI4genetic
27708008
GCN20_YEASTGCN20genetic
27708008
YG51_YEASTYGR237Cgenetic
27708008
IST3_YEASTIST3genetic
27708008
MGA2_YEASTMGA2genetic
27708008
DLS1_YEASTDLS1genetic
27708008
GSH1_YEASTGSH1genetic
27708008
RL8B_YEASTRPL8Bgenetic
27708008
ARP6_YEASTARP6genetic
27708008
COA4_YEASTCOA4genetic
27708008
UBX2_YEASTUBX2genetic
27708008
AMPD_YEASTAMD1genetic
27708008
GBLP_YEASTASC1genetic
27708008
SIP18_YEASTSIP18genetic
27708008
COX5A_YEASTCOX5Agenetic
27708008
MAS5_YEASTYDJ1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
AIM39_YEASTAIM39genetic
27708008
CY1_YEASTCYT1genetic
27708008
ELP4_YEASTELP4genetic
27708008
CARP_YEASTPEP4genetic
27708008
CISY3_YEASTCIT3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHO4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-47; SER-58; TYR-59;SER-276 AND SER-278, AND MASS SPECTROMETRY.

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