PYRD_YEAST - dbPTM
PYRD_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PYRD_YEAST
UniProt AC P28272
Protein Name Dihydroorotate dehydrogenase (fumarate)
Gene Name URA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 314
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. Does not use oxaloacetate or NAD or NADP as electron acceptors..
Protein Sequence MTASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISVPLGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSIDENLNLLRKIQDSEFNGITELNLSCPNVPGKPQVAYDFDLTKETLEKVFAFFKKPLGVKLPPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIEKELKDIMEAKGYTSIDQFRGKLNSI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTASLTTKF
------CCCCHHHHH		25.5921126336
46UbiquitinationKAGAFITKSATTLER
CCCEEEEECCCCHHC		33.0223749301
462-HydroxyisobutyrylationKAGAFITKSATTLER
CCCEEEEECCCCHHC		33.02-
46SuccinylationKAGAFITKSATTLER
CCCEEEEECCCCHHC		33.0223954790
46AcetylationKAGAFITKSATTLER
CCCEEEEECCCCHHC		33.0224489116
155AcetylationLTKETLEKVFAFFKK
CCHHHHHHHHHHHCC		45.8524489116
161SuccinylationEKVFAFFKKPLGVKL
HHHHHHHCCCCCCCC		47.2123954790
161AcetylationEKVFAFFKKPLGVKL
HHHHHHHCCCCCCCC		47.2124489116
214SuccinylationEKESVVVKPKNGFGG
CCCEEEEECCCCCCC		38.3723954790
216AcetylationESVVVKPKNGFGGIG
CEEEEECCCCCCCCC		65.0822865919
228AcetylationGIGGEYVKPTALANV
CCCCCCCCHHHHHHH		35.4324489116
239PhosphorylationLANVRAFYTRLRPEI
HHHHHHHHHHHCCCC		7.0322369663
240PhosphorylationANVRAFYTRLRPEIK
HHHHHHHHHHCCCCE		19.4422369663
247UbiquitinationTRLRPEIKVIGTGGI
HHHCCCCEEEECCCC		26.5824961812
247AcetylationTRLRPEIKVIGTGGI
HHHCCCCEEEECCCC		26.5824489116
255SuccinylationVIGTGGIKSGKDAFE
EEECCCCCCCHHHHH		57.3323954790
283AcetylationELQKEGVKIFERIEK
HHHHHHHHHHHHHHH		53.1624489116
290AcetylationKIFERIEKELKDIME
HHHHHHHHHHHHHHH		67.0124489116
293AcetylationERIEKELKDIMEAKG
HHHHHHHHHHHHHCC		46.4224489116
293SuccinylationERIEKELKDIMEAKG
HHHHHHHHHHHHHCC		46.4223954790
293UbiquitinationERIEKELKDIMEAKG
HHHHHHHHHHHHHCC		46.4223749301
299AcetylationLKDIMEAKGYTSIDQ
HHHHHHHCCCCCHHH		38.8624489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PYRD_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PYRD_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PYRD_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FRDS_YEASTFRD1genetic
16941010
ODPA_YEASTPDA1genetic
21623372
FABG_YEASTOAR1genetic
21623372
ERG2_YEASTERG2genetic
21623372
PPT2_YEASTPPT2genetic
21623372
KAD2_YEASTADK1genetic
21623372
ERF3_YEASTSUP35genetic
27708008
TFB1_YEASTTFB1genetic
27708008
RMRP_YEASTSNM1genetic
27708008
BRR6_YEASTBRR6genetic
27708008
DAM1_YEASTDAM1genetic
27708008
CBF3A_YEASTCBF2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
ERG27_YEASTERG27genetic
27708008
DIB1_YEASTDIB1genetic
27708008
ODPB_YEASTPDB1genetic
27708008
CEM1_YEASTCEM1genetic
27708008
DLDH_YEASTLPD1genetic
27708008
ACBP_YEASTACB1genetic
27708008
LPLA_YEASTAIM22genetic
27708008
LIPB_YEASTLIP2genetic
27708008
ERG5_YEASTERG5genetic
27708008
HFA1_YEASTHFA1genetic
27708008
PET8_YEASTPET8genetic
27708008
ODP2_YEASTLAT1genetic
27708008
LIPA_YEASTLIP5genetic
27708008
FABD_YEASTMCT1genetic
27708008
GFAP_HUMANGFAPphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PYRD_YEAST

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Related Literatures of Post-Translational Modification

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