TOS2_YEAST - dbPTM
TOS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TOS2_YEAST
UniProt AC P50078
Protein Name Protein TOS2
Gene Name TOS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 622
Subcellular Localization Cell membrane
Single-pass membrane protein . Bud membrane
Single-pass membrane protein .
Protein Description Seems to be involved in the anchoring of CDC24 to the membrane of polarized growth sites..
Protein Sequence MFSHYRYKENSCQKREAIPDKSRVSLTFLQKRTDSSNVTVAVAVAVPIGAIIIVLSVVLIVVYRRCKKEPSMQDFDPNFEGDLYYLPKMDSSMNSANSDSNATEKRFIYGGYDDFLQPSIENSQSFKDYVRRINEHAPSAYNIASLASQNNSKLSVPSKHIDLSNKISFESLENSELIVSPQHSNTGQDCDQRCDSTSNPDVNEKSSHNNDNRLKSNYTSRSGLEPQCSREEEENIDRIRSIYNIYFEKSNSTIRSSVTSSIRRDSKLNIATRKSVNMSSQDNPNDTTLIEQSHFGSTTVQEIDSSSSANEEYEDATDYLQVPAPQENKNIASSVYSEVATREKVIPESSLSLTFPPPNGLSTRITSSIYSDTVAKDHIHSAKAPVRALSEGSGQSNLTSAQQYSTYFIDHCNQSNDDNYYYNYPLPLEHPQNYENIGDLPTPTQFIYSTSSHSLTSFKGRPKPPKTLKHVPTARLNGTALNPMDHPEMFYSSPTKIPSTSLTKQFCTPLPYQLRQSVVMTNPSELSMKPRYKPAGSLRNLIKAQYLPGNSSTTTSSSLSQPPSTLSNAINFRVSGLLDDTDILQPPSVGEILPFKASTEDLRKQLGTSHNYEITPYENVHV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
119PhosphorylationYDDFLQPSIENSQSF
CCCCCCCHHCCCHHH		29.5821440633
123PhosphorylationLQPSIENSQSFKDYV
CCCHHCCCHHHHHHH		17.8924961812
125PhosphorylationPSIENSQSFKDYVRR
CHHCCCHHHHHHHHH		33.8021440633
198PhosphorylationDQRCDSTSNPDVNEK
HHCCCCCCCCCCCCC		50.7623749301
229PhosphorylationSGLEPQCSREEEENI
CCCCCCCCHHHHHHH		37.1623749301
241PhosphorylationENIDRIRSIYNIYFE
HHHHHHHHHHEEEEE		27.3629734811
334PhosphorylationENKNIASSVYSEVAT
CCCCHHHHHHHHHHC		18.9521440633
337PhosphorylationNIASSVYSEVATREK
CHHHHHHHHHHCCCC		24.3621440633
521PhosphorylationLRQSVVMTNPSELSM
HCCEEEECCHHHHHC		32.1627017623
599PhosphorylationILPFKASTEDLRKQL
CCCCCCCHHHHHHHH		38.0821440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TOS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TOS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TOS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KPC1_YEASTPKC1physical
11489916
UME6_YEASTUME6genetic
17314980
XRN1_YEASTXRN1genetic
17314980
MED5_YEASTNUT1genetic
17314980
ACT_YEASTACT1genetic
17314980
RGD1_YEASTRGD1physical
21143383
ORC6_YEASTORC6genetic
27708008
MED10_YEASTNUT2genetic
27708008
POP7_YEASTPOP7genetic
27708008
CDC53_YEASTCDC53genetic
27708008
CWC2_YEASTCWC2genetic
27708008
UBC3_YEASTCDC34genetic
27708008
LCB2_YEASTLCB2genetic
27708008
GPI11_YEASTGPI11genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
RPN1_YEASTRPN1genetic
27708008
ATC7_YEASTNEO1genetic
27708008
GPI15_YEASTGPI15genetic
27708008
NOP2_YEASTNOP2genetic
27708008
HRP1_YEASTHRP1genetic
27708008
IPL1_YEASTIPL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TOS2_YEAST

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Related Literatures of Post-Translational Modification

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