TSR2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSR2_YEAST
• UniProt AC: Q06672
• Protein Name: Pre-rRNA-processing protein TSR2
• Gene Name: TSR2 {ECO:0000312|SGD:S000004427}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 205
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Required for 20S pre-rRNA processing..
• Protein Sequence: MSTQYIDETAFVQAEQGKTNLMFSDEKQQARFELGVSMVIYKWDALDVAVENSWGGPDSAEKRDWITGIVVDLFKNEKVVDAALIEETLLYAMIDEFETNVEDDSALPIAVEVINIYNDCFNLNYNKVEKLYLEWQEKQRTKKSKRVVHIEGDDDEDDEDVEDYDDEDEDEEMDEVVPDLVSSKPEPIVDEDGFELVQPKGRRKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Ubiquitination	NLMFSDEKQQARFEL EECCCCHHHHHHHHH	53.34	23749301
27	Acetylation	NLMFSDEKQQARFEL EECCCCHHHHHHHHH	53.34	24489116
138	Acetylation	LYLEWQEKQRTKKSK HHHHHHHHHCCCCCC	29.94	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSR2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSR2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSR2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSR2_YEAST	TSR2	physical	14759368
RS26A_YEAST	RPS26A	physical	12837249
SLA1_YEAST	SLA1	physical	16554755
TCM62_YEAST	TCM62	physical	16554755
TXTP_YEAST	CTP1	physical	16554755
YRA1_YEAST	YRA1	physical	16554755
RS26B_YEAST	RPS26B	physical	16554755
PUF4_YEAST	PUF4	physical	16554755
STM1_YEAST	STM1	physical	16554755
RIO2_YEAST	RIO2	physical	16554755
NOP53_YEAST	NOP53	physical	16554755
RPB1_YEAST	RPO21	genetic	19061648
RS8A_YEAST	RPS8A	genetic	19061648
RS8B_YEAST	RPS8A	genetic	19061648
NMD5_YEAST	NMD5	genetic	19061648
LTV1_YEAST	LTV1	genetic	19061648
SRS2_YEAST	SRS2	genetic	21459050
RS26A_YEAST	RPS26A	physical	25144938
RS26B_YEAST	RPS26B	physical	25144938
IMB2_YEAST	KAP104	physical	25144938
IMB4_YEAST	KAP123	physical	25144938
IMB3_YEAST	PSE1	physical	25144938
GSP1_YEAST	GSP1	physical	25144938
KAD6_YEAST	FAP7	genetic	27929371
IMB4_YEAST	KAP123	genetic	27811238
RS14A_YEAST	RPS14A	genetic	27929371

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.