RS26A_YEAST - dbPTM
RS26A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RS26A_YEAST
UniProt AC P39938
Protein Name 40S ribosomal protein S26-A {ECO:0000303|PubMed:9559554}
Gene Name RPS26A {ECO:0000303|PubMed:9559554}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 119
Subcellular Localization Cytoplasm .
Protein Description Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel..
Protein Sequence MPKKRASNGRNKKGRGHVKPVRCVNCSKSIPKDKAIKRMAIRNIVEAAAVRDLSEASVYPEYALPKTYNKLHYCVSCAIHARIVRVRSREDRKNRAPPQRPRFNRENKVSPADAAKKAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19SuccinylationKKGRGHVKPVRCVNC
CCCCCCCCCEEECCC		31.9223954790
27PhosphorylationPVRCVNCSKSIPKDK
CEEECCCCCCCCCCH		25.0027717283
28UbiquitinationVRCVNCSKSIPKDKA
EEECCCCCCCCCCHH		55.3823749301
32UbiquitinationNCSKSIPKDKAIKRM
CCCCCCCCCHHHHHH		70.9122817900
34UbiquitinationSKSIPKDKAIKRMAI
CCCCCCCHHHHHHHH		59.1322817900
37UbiquitinationIPKDKAIKRMAIRNI
CCCCHHHHHHHHHHH		40.7722817900
54PhosphorylationAAAVRDLSEASVYPE
HHHHCCHHHHCCCCH		35.0922369663
57PhosphorylationVRDLSEASVYPEYAL
HCCHHHHCCCCHHHC		20.3822890988
59PhosphorylationDLSEASVYPEYALPK
CHHHHCCCCHHHCCC		6.4522890988
62PhosphorylationEASVYPEYALPKTYN
HHCCCCHHHCCCCCC		14.6622890988
66AcetylationYPEYALPKTYNKLHY
CCHHHCCCCCCHHHH		65.5724489116
66UbiquitinationYPEYALPKTYNKLHY
CCHHHCCCCCCHHHH		65.5723749301
66SuccinylationYPEYALPKTYNKLHY
CCHHHCCCCCCHHHH		65.5723954790
70UbiquitinationALPKTYNKLHYCVSC
HCCCCCCHHHHHHHH		26.6523749301
108UbiquitinationPRFNRENKVSPADAA
CCCCCCCCCCHHHHH		39.0623749301
110PhosphorylationFNRENKVSPADAAKK
CCCCCCCCHHHHHHH		18.9128889911
116UbiquitinationVSPADAAKKAL----
CCHHHHHHHHC----		40.0623749301
116SuccinylationVSPADAAKKAL----
CCHHHHHHHHC----		40.0623954790
1162-HydroxyisobutyrylationVSPADAAKKAL----
CCHHHHHHHHC----		40.06-
117UbiquitinationSPADAAKKAL-----
CHHHHHHHHC-----		50.6317644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RS26A_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RS26A_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RS26A_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TSR2_YEASTTSR2physical
10688190
RS26B_YEASTRPS26Bgenetic
22377630
TSR2_YEASTTSR2physical
25144938
RS26B_YEASTRPS26Bgenetic
25144938
SWI6_YEASTSWI6genetic
27708008
YCQ6_YEASTYCR016Wgenetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
VPS41_YEASTVPS41genetic
27708008
RS26B_YEASTRPS26Bgenetic
27708008
BST1_YEASTBST1genetic
27708008
STB5_YEASTSTB5genetic
27708008
CTF8_YEASTCTF8genetic
27708008
CSK21_YEASTCKA1genetic
27708008
IST3_YEASTIST3genetic
27708008
SDHX_YEASTYJL045Wgenetic
27708008
BFA1_YEASTBFA1genetic
27708008
ELM1_YEASTELM1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
NAP1_YEASTNAP1genetic
27708008
TSR2_YEASTTSR2genetic
27708008
STB4_YEASTSTB4genetic
27708008
PET8_YEASTPET8genetic
27708008
MET22_YEASTMET22genetic
27708008
CY1_YEASTCYT1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RS26A_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54, AND MASSSPECTROMETRY.

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