dbPTM

STB4_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	STB4_YEAST
UniProt AC	P50104
Protein Name	Probable transcriptional regulatory protein STB4
Gene Name	STB4
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	949
Subcellular Localization	Nucleus .
Protein Description	Binds to SIN3..
Protein Sequence	MSINHEIYYILVFEHRSVAIKLIIVVIVLLQFFLARSRQIDRTWAHTNRKERFREMTAIGNTDDALDTSTAASKENGKGRLRVQKACELCKKRKVKCDGNNPCLNCSKHQKECRYDFKATNRKRRRRQVASAVRDVSKTYAETSESFPRDLLSKSNIIINAPSDGVSSSASNSPNPNSHYHHISSTLPFMSGRPNHTFHSGSNLNGENNNNSFPEDHMAKLLLQLSSKLGNTTKESSIRTTRTNASDVNANPTVVNMKNSQEDCDTNHRSAICDSAEALHNNNINSKENKIINSQITNTVNDHFESPWQTFSLDKYRFHRRYQNILPYYLGVSILKDLSPQTIEYAKLKRPRVQNYGWNLSGGHYLKYKGDFRSQEKNIRHESKFFDFDDPVHLSLINKLLRYYFDEINPVFSIIHEATFWQQYNNKFLRQGKQNNSSANLFTSMLYLILSTTLRFREGHLDGQKGQGTYSNTSLNITFEEKSILIKKPSIEENLFKYAYLIINTLTFEWESFELIQSWLLITFYFRTCYRQTACWNALSQAVNMCNGMSLYLNKFPEIHSTYDESKAWHCFWCCFIMDKLISFQMGRFYQLSLPASEMCEQMNLVKSKKFLQEEDDWFHEETFQMLDLSIIVTQFLKRDAQDLNLNETVQLRSQLGQWYDTFIVGSQTNAYDDNYRYFYQVQPFMTYLDIRLTFEVRQLFCLIAPSSTANNKSLEYVVDTELLISHCQMAIENLAEITRSNLFFVPWWLNLSQLFTVNLICIIYLHAGIAVTQNKAIMQSCQEIWRTLECSKPKNRPSMLPECLWCLKMLNHMFCIRLRDSALQLEATLGTDHGDDTPNRNKFEQFKKVGDNDADVEVDAGEREENADERQENPHNNSKRVPLATRSHNTTNFDGSIAISPESAVANLGTDTGLPSDVLDTVSKIGNSPNVFDDDLFSNLLWFDQNFA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	KERFREMTAIGNTDD HHHHHHHHHCCCCCC	15.46	28889911
70	Phosphorylation	DDALDTSTAASKENG CCCCCCCHHHHHHCC	28.47	28889911
73	Phosphorylation	LDTSTAASKENGKGR CCCCHHHHHHCCCCC	37.73	28889911
260	Phosphorylation	TVVNMKNSQEDCDTN EEEECCCCHHHCCCC	29.45	21440633
275	Phosphorylation	HRSAICDSAEALHNN HHHHHHHHHHHHHHC	24.48	21440633
583	Phosphorylation	FIMDKLISFQMGRFY HHHHHHHHHHCCCCE	21.62	15665377
897	Phosphorylation	NTTNFDGSIAISPES CCCCCCCCEEECHHH	15.64	24961812
901	Phosphorylation	FDGSIAISPESAVAN CCCCEEECHHHHHHC	17.37	21440633
904	Phosphorylation	SIAISPESAVANLGT CEEECHHHHHHCCCC	31.28	21440633

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of STB4_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of STB4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of STB4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YK58_YEAST	YKR078W	physical	16554755
SODC_YEAST	SOD1	genetic	20959818
AP1_YEAST	YAP1	genetic	20959818
CTK1_YEAST	CTK1	genetic	21127252
BUB1_YEAST	BUB1	genetic	21127252
PPZ1_YEAST	PPZ1	genetic	21127252
CHA4_YEAST	CHA4	genetic	21127252
AP1_YEAST	YAP1	genetic	21127252
AFT1_YEAST	AFT1	genetic	21127252
SGF29_YEAST	SGF29	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
QCR9_YEAST	QCR9	genetic	27708008
PEX22_YEAST	PEX22	genetic	27708008
RS6A_YEAST	RPS6B	genetic	27708008
RS6B_YEAST	RPS6B	genetic	27708008
RIM1_YEAST	RIM1	genetic	27708008
SLX5_YEAST	SLX5	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
PHB2_YEAST	PHB2	genetic	27708008
CTK1_YEAST	CTK1	genetic	27708008
YL177_YEAST	YLR177W	genetic	27708008
MLH1_YEAST	MLH1	genetic	27708008
DIA2_YEAST	DIA2	genetic	27708008
COQ7_YEAST	CAT5	genetic	27708008
YME1_YEAST	YME1	genetic	27708008
MCM7_YEAST	MCM7	genetic	29674565
MRC1_YEAST	MRC1	genetic	29674565
STN1_YEAST	STN1	genetic	29674565
SLD3_YEAST	SLD3	genetic	29674565
ORC6_YEAST	ORC6	genetic	29674565
DPOD3_YEAST	POL32	genetic	29674565
RAD5_YEAST	RAD5	genetic	29674565
CEM1_YEAST	CEM1	genetic	29674565
CHO2_YEAST	CHO2	genetic	29674565
YJY1_YEAST	YJR011C	genetic	29674565
RS30A_YEAST	RPS30A	genetic	29674565
RS30B_YEAST	RPS30A	genetic	29674565
ADE_YEAST	AAH1	genetic	29674565
ATPN_YEAST	ATP20	genetic	29674565

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of STB4_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-583, AND MASSSPECTROMETRY.	15665377 [Abstract]