dbPTM

NMD5_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NMD5_YEAST
UniProt AC	P46970
Protein Name	Nonsense-mediated mRNA decay protein 5
Gene Name	NMD5
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	1048
Subcellular Localization	Nucleus. Cytoplasm.
Protein Description	Active in protein import into the nucleus. Its major import substrate is transcription elongation factor TFIIS..
Protein Sequence	MDITELLQCFACTLDHNAAVRTNAETHLKNASKVPGFLGACLDIIAADEVPENIKLSASLYFKNKITYGWSAGARQGSNELLDSHVDPDEKPVVKDMLIKTMVSVSKTSPRCIRVLKSALTVIISEDYPSKKWGNLLPNSLELLANEDITVTYVGLLCLAEIFRTYRWKNNDERQDLEELILNYFPALLNYGANVLFQDGKYMNNEQIGELVKLIIKIYKFVSYHDLPFTLQRSESFTPWACFFVSIIQQPLPQEVLAISDIEVRSKNPWVKCKKWALANLYRLFQRYASTSLTRKFQYDEFKQMYCEEFLTQFLQVVFDQIEKWGTGQLWLSDECLYYILNFVEQCVVQKTTWKLVGPHYNVILQHVIFPLLKPTAETLEAFDNDPQEYINRNMDFWDVGYSPDLAALALLTTCVTKRGKTTLQPTLEFMVSTLQSAVGDYNNIMLDNALQIESCLRIFSSIIDRLITKDSPFASEMEKFILTYVLPFFKSQYGFLQSRVCDICSKLGSMDFKDPVITSTIYEGVMNCLNNSSNSLPVELTAALALQTFISDDQFNMKLSEHVVPTMQKLLSLSNDFESDVISGVMQDFVEQFAEQLQPFGVELMNTLVQQFLKLAIDLHETSNLDPDSFTNVDSIPDESDKQMAALGILSTTISILLSFENSPEILKNLEQSFYPAAEFILKNDIEDFYRECCEFVENSTFLLRDITPISWKILELIGECNRKPDSMVSYYLSDFMLALNNILIYGRNELKKNEFYTKIIFEIYQKAVTAEDNSLDDLRVVFDLSQELVLALDDSLPQQYRERLLADVVGSILTQKNELKTNVVFSVTAFNVVISNMITEPLITLQYLKQQGCLEIFFQTWITDYIPNYKRCYDIKLSVLALLKIILKLESNDYSVLNLENLVPQLGSIVTQLASRLPTALRQLANQRKEFSSSGFEEDTKWDENFLDVGDDDENDDEGDLTEKYLELIKNRADSLDFVDGYDAKETFDDLEEDPLTGSILDTVDVYKVFKESIANLQHVDSNRYQGILRHLTPADQELFMGIMNA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	ETHLKNASKVPGFLG HHHHCHHHHCCCHHH	43.51	28889911
91	Acetylation	SHVDPDEKPVVKDML CCCCCCCCHHHHHHH	50.95	24489116
101	Phosphorylation	VKDMLIKTMVSVSKT HHHHHHHHHHCCCCC	18.79	27017623
130	Phosphorylation	IISEDYPSKKWGNLL EECCCCCCCCHHHCC	40.41	28889911
220	Acetylation	KLIIKIYKFVSYHDL HHHHHHHHHCCCCCC	42.64	24489116
623	Phosphorylation	LAIDLHETSNLDPDS HHHHHHHHCCCCCCC	16.50	24961812
624	Phosphorylation	AIDLHETSNLDPDSF HHHHHHHCCCCCCCC	32.20	24961812
630	Phosphorylation	TSNLDPDSFTNVDSI HCCCCCCCCCCCCCC	39.08	24961812
632	Phosphorylation	NLDPDSFTNVDSIPD CCCCCCCCCCCCCCC	37.98	24961812
822	Ubiquitination	LTQKNELKTNVVFSV HHCCCCCCCCEEEEE	31.69	19722269
880	Phosphorylation	RCYDIKLSVLALLKI CHHHHHHHHHHHHHH	15.30	28889911
934	Phosphorylation	ANQRKEFSSSGFEED HHHCHHHHCCCCCCC	25.37	27717283
935	Phosphorylation	NQRKEFSSSGFEEDT HHCHHHHCCCCCCCC	39.54	27717283
936	Phosphorylation	QRKEFSSSGFEEDTK HCHHHHCCCCCCCCC	46.43	27717283
977	Phosphorylation	LIKNRADSLDFVDGY HHHHCCHHCCCCCCC	28.93	22369663
984	Phosphorylation	SLDFVDGYDAKETFD HCCCCCCCCHHHCCC	14.31	19779198
1013	Acetylation	VDVYKVFKESIANLQ HHHHHHHHHHHHCCC	54.24	24489116
1024	Phosphorylation	ANLQHVDSNRYQGIL HCCCCCCCCCHHHHH	23.32	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NMD5_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NMD5_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NMD5_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFS2_YEAST	DST1	physical	9852143
NUP1_YEAST	NUP1	physical	9852143
NUP2_YEAST	NUP2	physical	9852143
NU159_YEAST	NUP159	physical	9852143
MDN1_YEAST	MDN1	physical	16429126
TBB_YEAST	TUB2	physical	16429126
HSC82_YEAST	HSC82	physical	16429126
GCN1_YEAST	GCN1	physical	16429126
TBA1_YEAST	TUB1	physical	16429126
HSP74_YEAST	SSA4	physical	15001563
RPF1_YEAST	RPF1	physical	16581791
ASR1_YEAST	ASR1	physical	17485461
YPT6_YEAST	YPT6	genetic	19061648
IF2M_YEAST	IFM1	genetic	19061648
SAC3_YEAST	SAC3	genetic	19547744

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NMD5_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-977, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-977, AND MASSSPECTROMETRY.	17563356 [Abstract]