| UniProt ID | LAM1_YEAST | |
|---|---|---|
| UniProt AC | P38851 | |
| Protein Name | Membrane-anchored lipid-binding protein LAM1 {ECO:0000303|PubMed:26001273} | |
| Gene Name | LAM1 {ECO:0000303|PubMed:26001273} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1228 | |
| Subcellular Localization |
Mitochondrion membrane Single-pass membrane protein . Endoplasmic reticulum membrane Single-pass membrane protein . Localizes to puncta in the cell periphery representing cortical endoplasmic reticulum (cER)-plasma membrane (PM) membrane contact |
|
| Protein Description | Involved in mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone. [PubMed: 15657396] | |
| Protein Sequence | MHEHKAELRLITVALNEASTDSPSFRASVNYFHTRMESLSSWMHSTVDYVENTYKPSFQDFQRIKETLFSQLLPSPILLSNGFVSNQPYTPLLVRDFTRDVSDLSNTVMKIILGDENSQYTAALSALSSDAINPYFNKRKTFEYYQRKYDSFLTDFLAATNDGNTLIPQNLQNETFKLVDIKHKYIEASLDLTEAISLMKVNLDKFLIETIDIVRKNNVITTKDTKDVIDITPELTETLKDWTDWIESNLQTLQALSSKLSEAKYAILKLSLARMKPSRLIQDYDLKSIQNLKFNLPKSISNGNNSEEKGLSGWLYMKTTVGHDPKRVVWVRRWCFLQNNVFGVFSLSPSKTYVEETDKFGILWITVEYLPKEPRNFCFKLRIQNPNCKTEEENTYIDIILQAESIDELKSWINTLTSHKRIALSIKEENDPRYQLARKKIEPQFFEFASSSSTSTDKLLTSFSSKTLTLVEELKKNYMSEDDIYSIIDNKAYHLRVISTPIATQLTHLALFSTFLSVSNYYPCATQANTWGTANWNDLSYLVNPLKGSSVHKPATVSNSSRFSVSYPDYYPYSLKVDDIQFRSIFFSVNHDFLQVPKELVLLRYSSVWCPNNKQKFASMAFVTLNHIYVYLNISGFSYLRRIDLLDIDSIEYDKSPKHVSSRMLHMQRGDGLRFNMSVFFTDRRAVASKLQFLIENKAMHIPKGEKEVLEIFQELDEEIENEKKIIKDNLSESEHYSKDYDYLLKSTYDHHFENTNETPMELMSRKLRLEREAWCYFQDNFKVGSKTLFHVLFGDKSQVFPSSLFLCKKGSNLNNNSYWERIRRAKEDASCQFELCRKLQFQLNRTSNFIKDLLWLKDDNDNFKLVLQQRVTKIKQGYYFEVEEGPIIVKFPLCHPLLLRVRFIIAECITSQGESLKKCDLAILYDFNYVESIDKLNTKVEKLWLFERIHLNWALRYCKLEHSEINRKTREYLKKFNDREKMSDVIKLCGFLGVLPKERIENDEKAGDFMQPVYINYDFLSLSKIFTKLTVFYLSSVIIKTMKVLLAMVMVIFKCFSKVNKTLYYCLLISAVTNLFFVGKSIHSYFSVKSAETLFQNYANGDQRGLQIMHRSLTVPDLNLLTRKMMDNDQENPVFKRFDEDKNAYQYKGTRQEIAIKRNQVLTELKILQNTEKELVQGSYRKFIITERDKCITTQNEIFDLWINDTKLQDYCMACFAEYNRLSAIPV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 38 | Phosphorylation | YFHTRMESLSSWMHS HHHHHHHHHHHHHHH | 28889911 | ||
| 45 | Phosphorylation | SLSSWMHSTVDYVEN HHHHHHHHHHHHHHH | 28889911 | ||
| 49 | Phosphorylation | WMHSTVDYVENTYKP HHHHHHHHHHHCCCC | 28889911 | ||
| 53 | Phosphorylation | TVDYVENTYKPSFQD HHHHHHHCCCCCHHH | 28889911 | ||
| 54 | Phosphorylation | VDYVENTYKPSFQDF HHHHHHCCCCCHHHH | 28889911 | ||
| 102 | Phosphorylation | RDFTRDVSDLSNTVM EECCCCHHHHHHCCE | 19779198 | ||
| 121 | Phosphorylation | GDENSQYTAALSALS CCCCHHHHHHHHHHC | 19779198 | ||
| 145 | Phosphorylation | KRKTFEYYQRKYDSF CCHHHHHHHHHHHHH | 25521595 | ||
| 185 | Phosphorylation | LVDIKHKYIEASLDL EEECCHHHHHHCCCH | 28889911 | ||
| 189 | Phosphorylation | KHKYIEASLDLTEAI CHHHHHHCCCHHHHH | 28889911 | ||
| 301 | Phosphorylation | FNLPKSISNGNNSEE ECCCCCCCCCCCCHH | 21440633 | ||
| 312 | Phosphorylation | NSEEKGLSGWLYMKT CCHHCCCCCEEEEEE | 21440633 | ||
| 411 | Phosphorylation | ESIDELKSWINTLTS CCHHHHHHHHHHHHC | 25521595 | ||
| 415 | Phosphorylation | ELKSWINTLTSHKRI HHHHHHHHHHCCCEE | 25521595 | ||
| 418 | Phosphorylation | SWINTLTSHKRIALS HHHHHHHCCCEEEEE | 25521595 | ||
| 478 | Phosphorylation | VEELKKNYMSEDDIY HHHHHHHCCCHHHCH | 30377154 | ||
| 480 | Phosphorylation | ELKKNYMSEDDIYSI HHHHHCCCHHHCHHH | 30377154 | ||
| 485 | Phosphorylation | YMSEDDIYSIIDNKA CCCHHHCHHHHCCCC | 30377154 | ||
| 564 | Phosphorylation | VSNSSRFSVSYPDYY CCCCCCCEECCCCCC | 30377154 | ||
| 567 | Phosphorylation | SSRFSVSYPDYYPYS CCCCEECCCCCCCCE | 30377154 | ||
| 570 | Phosphorylation | FSVSYPDYYPYSLKV CEECCCCCCCCEEEC | 30377154 | ||
| 571 | Phosphorylation | SVSYPDYYPYSLKVD EECCCCCCCCEEECC | 30377154 | ||
| 573 | Phosphorylation | SYPDYYPYSLKVDDI CCCCCCCCEEECCCE | 30377154 | ||
| 574 | Phosphorylation | YPDYYPYSLKVDDIQ CCCCCCCEEECCCEE | 30377154 | ||
| 732 | Phosphorylation | KIIKDNLSESEHYSK HHHHCCCCCCCHHCC | 22369663 | ||
| 734 | Phosphorylation | IKDNLSESEHYSKDY HHCCCCCCCHHCCCH | 22369663 | ||
| 743 | Phosphorylation | HYSKDYDYLLKSTYD HHCCCHHHHHHHHHH | 21440633 | ||
| 1036 | Phosphorylation | KLTVFYLSSVIIKTM HHHHHHHHHHHHHHH | 28889911 | ||
| 1037 | Phosphorylation | LTVFYLSSVIIKTMK HHHHHHHHHHHHHHH | 28889911 | ||
| 1085 | Phosphorylation | FVGKSIHSYFSVKSA HCCCCHHHHCCCCCH | 27017623 | ||
| 1094 | Phosphorylation | FSVKSAETLFQNYAN CCCCCHHHHHHHHCC | 27017623 | ||
| 1099 | Phosphorylation | AETLFQNYANGDQRG HHHHHHHHCCCCCCC | 27017623 | ||
| 1205 | N-linked_Glycosylation | EIFDLWINDTKLQDY HHHHHHCCCHHHHHH | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LAM1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LAM1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LAM1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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