NM111_YEAST - dbPTM
NM111_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NM111_YEAST
UniProt AC P53920
Protein Name Pro-apoptotic serine protease NMA111
Gene Name NMA111
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 997
Subcellular Localization Nucleus .
Protein Description Nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor BIR1..
Protein Sequence MTISLSNIKKRDHSKISDGTSGESSLVKRKQLESATGDQEEEYTDHEIIIEPLHFANNNNTVLTDSENYLRWQNTISNVVKSVVSIHFSQVAPFDCDSALVSEATGFVVDAKLGIILTNRHVVGPGPFVGYVVFDNHEECDVIPIYRDPVHDFGFLKFDPKNIKYSKIKALTLKPSLAKVGSEIRVVGNDAGEKLSILAGFISRIDRNAPEYGELTYNDFNTEYIQAAASASGGSSGSPVVNIDGYAVALQAGGSTEASTDFFLPLDRILRALICIQTNKPITRGTIQVQWLLKPYDECRRLGLTSERESEARAKFPENIGLLVAETVLREGPGYDKIKEGDTLISINGETISSFMQVDKIQDENVGKEIQLVIQRGGVECTVTCTVGDLHAITPHRYVEVCGATFHELSYQMARFYALPVRGVFLSSASGSFNFDSKERVGWIVDSIDNKETPDLDTFIEIMKTIPDRKRVTVRYHHLTDQHSPLVTSIYIDRHWCNEFRVYTRNDTTGIWDYKNVADPLPADALKPRSAKIIPIPVNNEKVAKLSSSLCTVATMAAVPLDSLSADILKTSGLIIDAEKGYVLVSRRVVPHDCLDTFVTIADSLVVPATVEFLHPTHNFAIVKYDPELVKAPLITPKLSTTRMKRGDKLQFIGFTQNDRIVTSETTVTDISSVSIPSNLIPRYRATNLEAISIDCNVSTRCNSGILTDNDGTVRGLWLPFLGERLENKEKVYLMGLDIMDCREVIDILKNGGKPRVSIVDAGFGSISVLQARIRGVPEEWIMRMEHESNNRLQFITVSRVSYTEDKIHLETGDVILSVNGKLVTEMNDLNGVVSSADGILPSAMLDFKVVRDGNIVDLKIKTVEVQETDRFVIFAGSILQKPHHAVLQAMVDVPKGVYCTFRGESSPALQYGISATNFITHVNEIETPDLDTFLKVVKTIPDNSYCKMRLMTFDNVPFAISLKTNYHYFPTAELKRDNITHKWIEKEFTGNSQSEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTISLSNIK
------CCEECCCCC		21.1922369663
4Phosphorylation----MTISLSNIKKR
----CCEECCCCCCC		19.3122369663
6Phosphorylation--MTISLSNIKKRDH
--CCEECCCCCCCCC		29.7122369663
14PhosphorylationNIKKRDHSKISDGTS
CCCCCCCCCCCCCCC		35.6530377154
15AcetylationIKKRDHSKISDGTSG
CCCCCCCCCCCCCCC		42.6924489116
17PhosphorylationKRDHSKISDGTSGES
CCCCCCCCCCCCCCC		33.4522369663
20PhosphorylationHSKISDGTSGESSLV
CCCCCCCCCCCCHHE		38.2522369663
21PhosphorylationSKISDGTSGESSLVK
CCCCCCCCCCCHHEE		46.2022369663
24PhosphorylationSDGTSGESSLVKRKQ
CCCCCCCCHHEEHHH		32.2822369663
25PhosphorylationDGTSGESSLVKRKQL
CCCCCCCHHEEHHHH		32.6422369663
28AcetylationSGESSLVKRKQLESA
CCCCHHEEHHHHHCC		60.2025381059
28UbiquitinationSGESSLVKRKQLESA
CCCCHHEEHHHHHCC		60.2023749301
43PhosphorylationTGDQEEEYTDHEIII
CCCCCCCCCCCEEEE		22.2819779198
44PhosphorylationGDQEEEYTDHEIIIE
CCCCCCCCCCEEEEE		33.8723749301
61PhosphorylationHFANNNNTVLTDSEN
EECCCCCCEEECCCH		21.0019779198
174AcetylationKIKALTLKPSLAKVG
HEEEEEECHHHHHCC		27.5924489116
194UbiquitinationVGNDAGEKLSILAGF
ECCCHHHHHHHHHHH		46.7623749301
278PhosphorylationRALICIQTNKPITRG
HHHHHHHCCCCCCCC		25.8730377154
470AcetylationMKTIPDRKRVTVRYH
HHHCCCCCCEEEEEE		59.6125381059
515AcetylationTTGIWDYKNVADPLP
CCCCCCCCCCCCCCC		42.3324489116
527AcetylationPLPADALKPRSAKII
CCCCCCCCCCCCEEE		39.8524489116
542AcetylationPIPVNNEKVAKLSSS
EECCCHHHHHHHHHH		50.0124489116
552PhosphorylationKLSSSLCTVATMAAV
HHHHHHHHHHHHHCC		20.6123749301
555PhosphorylationSSLCTVATMAAVPLD
HHHHHHHHHHCCCHH		11.7323749301
563PhosphorylationMAAVPLDSLSADILK
HHCCCHHHCCHHHHH		31.7223749301
565PhosphorylationAVPLDSLSADILKTS
CCCHHHCCHHHHHHC		28.0423749301
631AcetylationKYDPELVKAPLITPK
ECCHHHHCCCCCCCC		57.8424489116
638AcetylationKAPLITPKLSTTRMK
CCCCCCCCCCCCCCC		46.5524489116
860AcetylationDGNIVDLKIKTVEVQ
CCCEEEEEEEEEEEE		37.3824489116
987AcetylationITHKWIEKEFTGNSQ
CCHHHCCHHHCCCCC		49.3324489116
990PhosphorylationKWIEKEFTGNSQSEK
HHCCHHHCCCCCCCC		36.2222369663
993PhosphorylationEKEFTGNSQSEK---
CHHHCCCCCCCC---		36.1122369663
995PhosphorylationEFTGNSQSEK-----
HHCCCCCCCC-----		100.0022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NM111_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NM111_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NM111_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LCF1_YEASTFAA1physical
16470384
FKBP3_YEASTFPR3genetic
18946088
POP7_YEASTPOP7genetic
27708008
APC11_YEASTAPC11genetic
27708008
CDC53_YEASTCDC53genetic
27708008
NUP85_YEASTNUP85genetic
27708008
RU1C_YEASTYHC1genetic
27708008
IMB1_YEASTKAP95genetic
27708008
YTM1_YEASTYTM1genetic
27708008
PSA7_YEASTPRE10genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NM111_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-21 AND SER-993,AND MASS SPECTROMETRY.

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