MSI1_YEAST - dbPTM
MSI1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSI1_YEAST
UniProt AC P13712
Protein Name Chromatin assembly factor 1 subunit p50
Gene Name MSI1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 422
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Acts as a component of chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto replicating DNA in vitro. It performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. p50 and p60 form complexes with newly synthesized histones H3 and acetylated H4 in cell extracts (By similarity). Independently, MSI1 is involved in regulation of the RAS/cAMP pathway via sequestration of NPR1..
Protein Sequence MNQCAKDITHEASSIPIDLQERYSHWKKNTKLLYDYLNTNSTKWPSLTCQFFPDLDTTSDEHRILLSSFTSSQKPEDETIYISKISTLGHIKWSSLNNFDMDEMEFKPENSTRFPSKHLVNDISIFFPNGECNRARYLPQNPDIIAGASSDGAIYIFDRTKHGSTRIRQSKISHPFETKLFGSHGVIQDVEAMDTSSADINEATSLAWNLQQEALLLSSHSNGQVQVWDIKQYSHENPIIDLPLVSINSDGTAVNDVTWMPTHDSLFAACTEGNAVSLLDLRTKKEKLQSNREKHDGGVNSCRFNYKNSLILASADSNGRLNLWDIRNMNKSPIATMEHGTSVSTLEWSPNFDTVLATAGQEDGLVKLWDTSCEETIFTHGGHMLGVNDISWDAHDPWLMCSVANDNSVHIWKPAGNLVGHS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Acetylation--MNQCAKDITHEAS
--CCCHHCCCCCCHH		58.2424489116
9PhosphorylationNQCAKDITHEASSIP
CCHHCCCCCCHHCCC		24.6522369663
13PhosphorylationKDITHEASSIPIDLQ
CCCCCCHHCCCCCHH		26.3022369663
14PhosphorylationDITHEASSIPIDLQE
CCCCCHHCCCCCHHH		39.1622369663
307UbiquitinationNSCRFNYKNSLILAS
CCCCCCCCCCEEEEE		40.9617644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSI1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSI1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSI1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SET3_YEASTSET3physical
11805837
CRC1_YEASTCRC1physical
11805837
RLF2_YEASTRLF2physical
11805837
SNU66_YEASTSNU66physical
11805837
NPR1_YEASTNPR1physical
11238915
RLF2_YEASTRLF2physical
11238915
RLF2_YEASTRLF2genetic
12750463
RPD3_YEASTRPD3genetic
10388812
SAP30_YEASTSAP30genetic
10388812
SIN3_YEASTSIN3genetic
10388812
ASF1_YEASTASF1genetic
16141196
CAC2_YEASTCAC2physical
16554755
RLF2_YEASTRLF2physical
16554755
HIR3_YEASTHIR3genetic
10101165
HIR1_YEASTHIR1genetic
17314980
FUS3_YEASTFUS3genetic
17314980
H4_YEASTHHF1genetic
17314980
RLF2_YEASTRLF2physical
17321547
NPR1_YEASTNPR1physical
17321547
YM44_YEASTYMR178Wphysical
17634282
MTAP_YEASTMEU1physical
18719252
PFD6_YEASTYKE2genetic
19547744
H3_YEASTHHT1physical
16015338
HIR3_YEASTHIR3genetic
9671488
ASF1_YEASTASF1genetic
16487579
CTF18_YEASTCTF18genetic
16487579
CTF4_YEASTCTF4genetic
16487579
CTF8_YEASTCTF8genetic
16487579
DCC1_YEASTDCC1genetic
16487579
HIR1_YEASTHIR1genetic
16487579
HIR2_YEASTHIR2genetic
16487579
HIR3_YEASTHIR3genetic
16487579
HPC2_YEASTHPC2genetic
16487579
MRE11_YEASTMRE11genetic
16487579
DPOD3_YEASTPOL32genetic
16487579
RAD50_YEASTRAD50genetic
16487579
XRS2_YEASTXRS2genetic
16487579
ISC1_YEASTISC1genetic
16487579
FEN1_YEASTRAD27genetic
16487579
NUP84_YEASTNUP84genetic
16487579
SPT3_YEASTSPT3genetic
20959818
HIR3_YEASTHIR3genetic
20959818
OAF1_YEASTOAF1genetic
20959818
HIR2_YEASTHIR2genetic
20959818
INO4_YEASTINO4genetic
27708008
RPN4_YEASTRPN4genetic
27708008
ARO1_YEASTARO1genetic
27708008
PLP1_YEASTPLP1genetic
27708008
GNTK_YEASTYDR248Cgenetic
27708008
SAC7_YEASTSAC7genetic
27708008
GCN1_YEASTGCN1genetic
27708008
HXKB_YEASTHXK2genetic
27708008
SLX9_YEASTSLX9genetic
27708008
ICE2_YEASTICE2genetic
27708008
ASF1_YEASTASF1genetic
27708008
DPOD3_YEASTPOL32genetic
27708008
HIR3_YEASTHIR3genetic
27708008
FEN1_YEASTRAD27genetic
27708008
SAM37_YEASTSAM37genetic
27708008
MRE11_YEASTMRE11genetic
27708008
SCS7_YEASTSCS7genetic
27708008
YM94_YEASTYMR315Wgenetic
27708008
MAS5_YEASTYDJ1genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
VPS27_YEASTVPS27genetic
27708008
BRE5_YEASTBRE5genetic
27708008
HIR2_YEASTHIR2genetic
27708008
RMI1_YEASTRMI1genetic
27708008
AIM44_YEASTAIM44genetic
27708008
FOB1_YEASTFOB1genetic
26912831
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSI1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14, AND MASSSPECTROMETRY.

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