PLP1_YEAST - dbPTM
PLP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLP1_YEAST
UniProt AC Q04004
Protein Name Phosducin-like protein 1
Gene Name PLP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 230
Subcellular Localization Cytoplasm .
Protein Description Not essential for growth. Inhibits early G-protein signaling events following pheromone stimulation. May help create heterodimerizable beta-tubulin by facilitating the efficient transfer of nascent beta-tubulin polypeptides to the folding apparatus..
Protein Sequence MEDKLDRYYTNVLSNAEKDKHTTVDSDDKSSGEENLDELLNELDRELDEDHEFLSAYRSERLQQISDHLKQVKKNVEDDGYGRLQCIDNEADAIQICTKTTMVVIHFELETFGKCQYMNEKLENLAKRYLTTRFIKVNVQTCPFLVNKLNIKVLPFVVGYKNGLEKVRYVGFSKLGNDPNGFDIRRLEQSLAHSGVIEDTFEIRKHSSVNTERFASTNHDRSESDSDLDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MEDKLDRY
-------CCHHHHHH		15.7722814378
10PhosphorylationDKLDRYYTNVLSNAE
HHHHHHHHHHHHHHH		15.2028889911
22PhosphorylationNAEKDKHTTVDSDDK
HHHHCCCCCCCCCCC		33.9717330950
23PhosphorylationAEKDKHTTVDSDDKS
HHHCCCCCCCCCCCC		23.2619795423
26PhosphorylationDKHTTVDSDDKSSGE
CCCCCCCCCCCCCCC		43.2917330950
30PhosphorylationTVDSDDKSSGEENLD
CCCCCCCCCCCCCHH		51.0419795423
31PhosphorylationVDSDDKSSGEENLDE
CCCCCCCCCCCCHHH		56.8317330950
66PhosphorylationSERLQQISDHLKQVK
HHHHHHHHHHHHHHH		18.0328889911
207PhosphorylationTFEIRKHSSVNTERF
EEEEECCCCCCCCCC		38.7319823750
208PhosphorylationFEIRKHSSVNTERFA
EEEECCCCCCCCCCC		21.0719823750
211PhosphorylationRKHSSVNTERFASTN
ECCCCCCCCCCCCCC		26.7819823750
216PhosphorylationVNTERFASTNHDRSE
CCCCCCCCCCCCCCC		27.3421440633
217PhosphorylationNTERFASTNHDRSES
CCCCCCCCCCCCCCC		32.8919779198
222PhosphorylationASTNHDRSESDSDLD
CCCCCCCCCCCCCCC		47.7322890988
224PhosphorylationTNHDRSESDSDLDI-
CCCCCCCCCCCCCC-		43.6022890988
226PhosphorylationHDRSESDSDLDI---
CCCCCCCCCCCC---		49.7222890988
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PLP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GPR1_YEASTGPR1genetic
27708008
BRE1_YEASTBRE1genetic
27708008
RL35A_YEASTRPL35Agenetic
27708008
RL35B_YEASTRPL35Agenetic
27708008
MGMT_YEASTMGT1genetic
27708008
CGR1_YEASTCGR1genetic
27708008
MFAL2_YEASTMF(ALPHA)2genetic
27708008
YGS6_YEASTYGL176Cgenetic
27708008
PFD3_YEASTPAC10genetic
27708008
SNF6_YEASTSNF6genetic
27708008
ICE2_YEASTICE2genetic
27708008
YRA2_YEASTYRA2genetic
27708008
PFD6_YEASTYKE2genetic
27708008
PFD4_YEASTGIM3genetic
27708008
INO4_YEASTINO4genetic
27708008
RRP6_YEASTRRP6genetic
27708008
TEA1_YEASTTEA1genetic
27708008
KAR3_YEASTKAR3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, AND MASSSPECTROMETRY.

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