MTNA_YEAST - dbPTM
MTNA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTNA_YEAST
UniProt AC Q06489
Protein Name Methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_03119}
Gene Name MRI1 {ECO:0000255|HAMAP-Rule:MF_03119}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 411
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)..
Protein Sequence MSLEAIVFDRSEPENVSVKVLDQLLLPYTTKYVPIHTIDDGYSVIKSMQVRGAPAIAIVGSLSVLTEVQLIKHNPTSDVATLYSLVNWESTKTVLNKRLDFLLSSRPTAVNLSNSLVEIKNILKSSSDLKAFDGSLYNYVCELIDEDLANNMKMGDNGAKYLIDVLQKDGFKDEFAVLTICNTGSLATSGYGTALGVIRSLWKDSLAKTDKADSGLDNEKCPRMGHVFPLETRPYNQGSRLTAYELVYDKIPSTLITDSSIAYRIRTSPIPIKAAFVGADRIVRNGDTANKIGTLQLAVICKQFGIKFFVVAPKTTIDNVTETGDDIIVEERNPEEFKVVTGTVINPENGSLILNESGEPITGKVGIAPLEINVWNPAFDITPHELIDGIITEEGVFTKNSSGEFQLESLF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSLEAIVFD
------CCCEEEEEC		34.6122814378
124UbiquitinationVEIKNILKSSSDLKA
HHHHHHHHCCCCHHH		44.4923749301
203AcetylationGVIRSLWKDSLAKTD
HHHHHHHHHHHCCCC		42.6124489116
209PhosphorylationWKDSLAKTDKADSGL
HHHHHCCCCCCCCCC		36.8128889911
211UbiquitinationDSLAKTDKADSGLDN
HHHCCCCCCCCCCCC		60.3623749301
214PhosphorylationAKTDKADSGLDNEKC
CCCCCCCCCCCCCCC		46.2228889911
220UbiquitinationDSGLDNEKCPRMGHV
CCCCCCCCCCCCCCE		56.6523749301
273UbiquitinationRTSPIPIKAAFVGAD
ECCCCCCEEEEECCC		28.4523749301
351PhosphorylationVINPENGSLILNESG
EECCCCCCEEECCCC		24.6625752575
357PhosphorylationGSLILNESGEPITGK
CCEEECCCCCCCCCE		47.5924961812
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTNA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTNA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTNA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTNA_YEASTMRI1physical
15215245
SVF1_YEASTSVF1physical
16429126
MTNA_YEASTMRI1physical
18719252
DCAM_YEASTSPE2genetic
23773701
CDC1_YEASTCDC1genetic
27708008
ARP3_YEASTARP3genetic
27708008
SWC5_YEASTSWC5genetic
27708008
VPS41_YEASTVPS41genetic
27708008
VAM7_YEASTVAM7genetic
27708008
PEX8_YEASTPEX8genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
ELM1_YEASTELM1genetic
27708008
POM33_YEASTPOM33genetic
27708008
AYT1_YEASTAYT1genetic
27708008
AHP1_YEASTAHP1genetic
27708008
RAD52_YEASTRAD52genetic
27708008
SOK2_YEASTSOK2genetic
27708008
MUB1_YEASTMUB1genetic
27708008
GAS1_YEASTGAS1genetic
27708008
MKT1_YEASTMKT1genetic
27708008
MDM38_YEASTMDM38genetic
27708008
CY1_YEASTCYT1genetic
27708008
BOB1_YEASTBOI1genetic
29674565
HOC1_YEASTHOC1genetic
29674565
SAC1_YEASTSAC1genetic
29674565
RPC1_YEASTRPO31genetic
29674565
TCPZ_YEASTCCT6genetic
29674565
RPN1_YEASTRPN1genetic
29674565
BUB3_YEASTBUB3genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTNA_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-351, AND MASSSPECTROMETRY.

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