| UniProt ID | RPC1_YEAST | |
|---|---|---|
| UniProt AC | P04051 | |
| Protein Name | DNA-directed RNA polymerase III subunit RPC1 | |
| Gene Name | RPO31 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1460 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).. | |
| Protein Sequence | MKEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKANGALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQRRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSSNGGGKVKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKIQASDVNIIGKDRIAINVFPEGYKAKSISTSAKEPSENDVFYRMQQLRRALPDVVVKGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNISEKDLVPKRCLFESLSNEAALKAN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MKEVVVSETPKRIK -CCEEEECCCCCCCC | 24.92 | 28889911 | |
| 9 | Phosphorylation | KEVVVSETPKRIKGL CEEEECCCCCCCCCC | 26.97 | 19823750 | |
| 44 | Acetylation | RDLFDLEKDRAPKAN HHCHHHHCCCCCCCC | 60.87 | 24489116 | |
| 194 | Acetylation | GKKSAPEKDIWVGEW CCCCCCCCCEEEEEH | 54.15 | 24489116 | |
| 232 | Acetylation | LKTLNLFKQIKSADC HHHHHHHHHHHHCCC | 55.04 | 24489116 | |
| 247 | Phosphorylation | ELLGIDATVPSGRPE EEECEEEECCCCCCC | 29.24 | 28152593 | |
| 288 | Ubiquitination | NEDDLTVKLTEIVWT CCCCCEEEHHHHHHH | 44.44 | 17644757 | |
| 300 | Ubiquitination | VWTSSLIKAGLDKGI HHHHHHHHHCCCCCC | 41.52 | 17644757 | |
| 358 | Acetylation | RGFCQRLKGKQGRFR HHHHHHHCCCCCCCC | 67.27 | 25381059 | |
| 360 | Acetylation | FCQRLKGKQGRFRGN HHHHHCCCCCCCCCC | 48.25 | 25381059 | |
| 371 | Ubiquitination | FRGNLSGKRVDFSGR CCCCCCCCEEECCCC | 45.96 | 17644757 | |
| 400 | Ubiquitination | AVPDRVAKVLTYPEK CCCCHHHHHHCCHHH | 34.61 | 17644757 | |
| 415 | Ubiquitination | VTRYNRHKLQELIVN HHCCCHHHCHHHHHC | 48.94 | 17644757 | |
| 435 | Ubiquitination | PGANYLLKRNEDARR CCCCCHHCCCHHHHH | 51.05 | 17644757 | |
| 676 | Phosphorylation | LGDGKKHSVFYTILR CCCCCCCCHHHHHHH | 23.85 | 27017623 | |
| 679 | Phosphorylation | GKKHSVFYTILRDYG CCCCCHHHHHHHHHC | 7.24 | 27017623 | |
| 685 | Phosphorylation | FYTILRDYGPQEAAN HHHHHHHHCHHHHHH | 25.03 | 27017623 | |
| 891 | Ubiquitination | YMSRRLMKSLEDLSC HHHHHHHHHHHHHHC | 57.38 | 17644757 | |
| 1037 | Ubiquitination | GLLEPPAKELQGIDP CCCCCCHHHHCCCCC | 65.81 | 17644757 | |
| 1053 | Ubiquitination | ETVPDNVKTSVSQLY CCCCCCHHCCHHHHH | 41.14 | 17644757 | |
| 1054 | Phosphorylation | TVPDNVKTSVSQLYR CCCCCHHCCHHHHHH | 30.03 | 19823750 | |
| 1055 | Phosphorylation | VPDNVKTSVSQLYRI CCCCHHCCHHHHHHC | 17.66 | 19823750 | |
| 1057 | Phosphorylation | DNVKTSVSQLYRISE CCHHCCHHHHHHCCH | 17.78 | 19823750 | |
| 1060 | Phosphorylation | KTSVSQLYRISEKSV HCCHHHHHHCCHHHH | 9.77 | 19823750 | |
| 1063 | Phosphorylation | VSQLYRISEKSVRKF HHHHHHCCHHHHHHH | 29.94 | 19823750 | |
| 1065 | Acetylation | QLYRISEKSVRKFLE HHHHCCHHHHHHHHH | 47.67 | 25381059 | |
| 1080 | Ubiquitination | IALFKYRKARLEPGT HHHHHHHHHHCCCCC | 34.47 | 17644757 | |
| 1107 | Ubiquitination | PGTQMTLKTFHFAGV CCCCEEEEEEEECCC | 39.72 | 17644757 | |
| 1216 | Ubiquitination | ITRASKLKIQASDVN HHHHHHCCEEHHCCE | 36.19 | 24961812 | |
| 1240 | Ubiquitination | NVFPEGYKAKSISTS EECCCCCCCCCCCCC | 61.26 | 23749301 | |
| 1242 | Ubiquitination | FPEGYKAKSISTSAK CCCCCCCCCCCCCCC | 44.14 | 23749301 | |
| 1249 | Ubiquitination | KSISTSAKEPSENDV CCCCCCCCCCCCCCH | 70.67 | 23749301 | |
| 1273 | Ubiquitination | ALPDVVVKGLPDISR HCCHHECCCCCCCEE | 43.02 | 23749301 | |
| 1341 | Phosphorylation | SIIREINYTMSNHGM HHHHHHCCHHHCCCC | 14.96 | 27017623 | |
| 1344 | Phosphorylation | REINYTMSNHGMSVD HHHCCHHHCCCCCCC | 20.20 | 27017623 | |
| 1432 | Ubiquitination | TGSFKVVKGTNISEK CCCEEEEECCCCCHH | 64.11 | 23749301 | |
| 1439 | Acetylation | KGTNISEKDLVPKRC ECCCCCHHHCCCCHH | 49.96 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RPC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RPC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RPC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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