RPC5_YEAST - dbPTM
RPC5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPC5_YEAST
UniProt AC P36121
Protein Name DNA-directed RNA polymerase III subunit RPC5
Gene Name RPC37
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 282
Subcellular Localization Nucleus .
Protein Description DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation..
Protein Sequence MSIDNKLFVTEEDEEDRTQDRADVEDESNDIDMIADENGTNSAIANEQEEKSEEVKAEDDTGEEEEDDPVIEEFPLKISGEEESLHVFQYANRPRLVGRKPAEHPFISAARYKPKSHLWEIDIPLDEQAFYNKDKAESEWNGVNVQTLKGVGVENNGQYAAFVKDMQVYLVPIERVAQLKPFFKYIDDANVTRKQEDARRNPNPSSQRAQVVTMSVKSVNDPSQNRLTGSLLAHKVADEEANIELTWAEGTFEQFKDTIVKEAEDKTLVALEKQEDYIDNLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationEEDEEDRTQDRADVE
CCCCCCCCCCCHHCC		47.3328889911
28PhosphorylationRADVEDESNDIDMIA
CHHCCCCCCCCEEEE		52.7227017623
52PhosphorylationANEQEEKSEEVKAED
HCCHHHHHHHCCCCC		42.1221440633
61PhosphorylationEVKAEDDTGEEEEDD
HCCCCCCCCCCCCCC		59.8322369663
184AcetylationAQLKPFFKYIDDANV
HHCCHHHHHCCCCCC		41.4924489116
185PhosphorylationQLKPFFKYIDDANVT
HCCHHHHHCCCCCCC		12.3927017623
192PhosphorylationYIDDANVTRKQEDAR
HCCCCCCCCCHHHHH		31.7727017623
205PhosphorylationARRNPNPSSQRAQVV
HHHCCCCCHHCEEEE		45.8230377154
206PhosphorylationRRNPNPSSQRAQVVT
HHCCCCCHHCEEEEE		25.5828889911
217UbiquitinationQVVTMSVKSVNDPSQ
EEEEEEEECCCCCCC		41.1823749301
217AcetylationQVVTMSVKSVNDPSQ
EEEEEEEECCCCCCC		41.1824489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPC5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPC5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPC5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YD144_YEASTYDL144Cphysical
16554755
FAR7_YEASTFAR7physical
16554755
RPC7_YEASTRPC31physical
16554755
RPC1_YEASTRPO31physical
16554755
RPC2_YEASTRET1physical
16554755
RPAC1_YEASTRPC40physical
16554755
RPC3_YEASTRPC82physical
16554755
RPC4_YEASTRPC53physical
21536656
RPC2_YEASTRET1physical
21536656
RPC6_YEASTRPC34physical
21536656
TFC5_YEASTBDP1physical
21536656
ORC2_YEASTORC2genetic
27708008
RPB1_YEASTRPO21genetic
27708008
FAL1_YEASTFAL1genetic
27708008
RRP1_YEASTRRP1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
UTP5_YEASTUTP5genetic
27708008
GPI19_YEASTGPI19genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
IPI1_YEASTIPI1genetic
27708008
IF2A_YEASTSUI2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
EI2BB_YEASTGCD7genetic
27708008
RNA1_YEASTRNA1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
CAP_YEASTSRV2genetic
27708008
EI2BG_YEASTGCD1genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
SLX5_YEASTSLX5genetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
VPS41_YEASTVPS41genetic
27708008
XRN1_YEASTXRN1genetic
27708008
YGZE_YEASTYGL260Wgenetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
SNX4_YEASTSNX4genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
RTG1_YEASTRTG1genetic
27708008
DIA2_YEASTDIA2genetic
27708008
RU2A_YEASTLEA1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPC5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-18; SER-52 AND THR-61,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-61, AND MASSSPECTROMETRY.

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