TFC5_YEAST - dbPTM
TFC5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TFC5_YEAST
UniProt AC P46678
Protein Name Transcription factor TFIIIB component B''
Gene Name BDP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 594
Subcellular Localization Nucleus.
Protein Description General activator of RNA polymerase III transcription..
Protein Sequence MSSIVNKSGTRFAPKVRQRRAATGGTPTPKPRTPQLFIPESKEIEEDNSDNDKGVDENETAIVEKPSLVGERSLEGFTLTGTNGHDNEIGDEGPIDASTQNPKADVIEDNVTLKPAPLQTHRDQKVPRSSRLASLSKDNESRPSFKPSFLDSSSNSNGTARRLSTISNKLPKKIRLGSITENDMNLKTFKRHRVLGKPSSAKKPAGAHRISIVSKISPPTAMTDSLDRNEFSSETSTSREADENENYVISKVKDIPKKVRDGESAKYFIDEENFTMAELCKPNFPIGQISENFEKSKMAKKAKLEKRRHLRELRMRARQEFKPLHSLTKEEQEEEEEKRKEERDKLLNADIPESDRKAHTAIQLKLNPDGTMAIDEETMVVDRHKNASIENEYKEKVDENPFANLYNYGSYGRGSYTDPWTVEEMIKFYKALSMWGTDFNLISQLYPYRSRKQVKAKFVNEEKKRPILIELALRSKLPPNFDEYCCEIKKNIGTVADFNEKLIELQNEHKHHMKEIEEAKNTAKEEDQTAQRLNDANLNKKGSGGIMTNDLKVYRKTEVVLGTIDDLKRKKLKERNNDDNEDNEGSEEEPEIDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationVRQRRAATGGTPTPK
HHHHHHHCCCCCCCC		34.8530377154
26PhosphorylationRRAATGGTPTPKPRT
HHHHCCCCCCCCCCC		25.9029136822
28PhosphorylationAATGGTPTPKPRTPQ
HHCCCCCCCCCCCCC		43.7229136822
33PhosphorylationTPTPKPRTPQLFIPE
CCCCCCCCCCCCCCC		24.7429136822
41PhosphorylationPQLFIPESKEIEEDN
CCCCCCCCCCCCCCC		30.1829136822
49PhosphorylationKEIEEDNSDNDKGVD
CCCCCCCCCCCCCCC		50.5422369663
60PhosphorylationKGVDENETAIVEKPS
CCCCCCCCEEEECCC		33.0122369663
67PhosphorylationTAIVEKPSLVGERSL
CEEEECCCCCCEECC		46.9122369663
73PhosphorylationPSLVGERSLEGFTLT
CCCCCEECCCCEEEE		26.8623749301
129PhosphorylationRDQKVPRSSRLASLS
CCCCCCCHHHHHHHC		17.4619823750
130PhosphorylationDQKVPRSSRLASLSK
CCCCCCHHHHHHHCC		32.3719823750
134PhosphorylationPRSSRLASLSKDNES
CCHHHHHHHCCCCCC		37.4524909858
136PhosphorylationSSRLASLSKDNESRP
HHHHHHHCCCCCCCC		35.1524909858
137AcetylationSRLASLSKDNESRPS
HHHHHHCCCCCCCCC		70.6225381059
153PhosphorylationKPSFLDSSSNSNGTA
CHHHCCCCCCCCCCH		32.9521551504
164PhosphorylationNGTARRLSTISNKLP
CCCHHHHHHHHHCCC		23.1425005228
165PhosphorylationGTARRLSTISNKLPK
CCHHHHHHHHHCCCC		32.7721440633
167PhosphorylationARRLSTISNKLPKKI
HHHHHHHHHCCCCCE		28.1828889911
169AcetylationRLSTISNKLPKKIRL
HHHHHHHCCCCCEEC		60.4224489116
178PhosphorylationPKKIRLGSITENDMN
CCCEECCCCCCCCCC		30.8119823750
180PhosphorylationKIRLGSITENDMNLK
CEECCCCCCCCCCHH		30.3622890988
184OxidationGSITENDMNLKTFKR
CCCCCCCCCHHHHHH		10.7615665377
211PhosphorylationPAGAHRISIVSKISP
CCCCCEEEEEEECCC		19.5221440633
214PhosphorylationAHRISIVSKISPPTA
CCEEEEEEECCCCCC		23.7027717283
233PhosphorylationLDRNEFSSETSTSRE
CCCCCCCCCCCCCCC		50.6521551504
235PhosphorylationRNEFSSETSTSREAD
CCCCCCCCCCCCCCC		38.9721551504
236PhosphorylationNEFSSETSTSREADE
CCCCCCCCCCCCCCC		21.9730377154
237PhosphorylationEFSSETSTSREADEN
CCCCCCCCCCCCCCC		38.9428889911
238PhosphorylationFSSETSTSREADENE
CCCCCCCCCCCCCCC		28.0830377154
247PhosphorylationEADENENYVISKVKD
CCCCCCCCEEEEEEC		7.9321551504
250PhosphorylationENENYVISKVKDIPK
CCCCCEEEEEECCCC		22.7321551504
251AcetylationNENYVISKVKDIPKK
CCCCEEEEEECCCCC		42.0324489116
388PhosphorylationVDRHKNASIENEYKE
EECCCCCCCCHHHHH		39.5730377154
415PhosphorylationYGSYGRGSYTDPWTV
CCCCCCCCCCCCCCH		24.4130377154
586PhosphorylationDNEDNEGSEEEPEID
CCCCCCCCCCCCCCC		35.3425521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TFC5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TFC5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TFC5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TFC4_YEASTTFC4physical
12930823
TFC4_YEASTTFC4physical
11739742
TF3B_YEASTBRF1physical
8662956
TBP_YEASTSPT15physical
8662956
TFC4_YEASTTFC4genetic
11971960
TF3B_YEASTBRF1genetic
11971960
TF3B_YEASTBRF1genetic
12885403
TBP_YEASTSPT15genetic
11971960
TFC4_YEASTTFC4genetic
12885403
ISW2_YEASTISW2genetic
15833918
TF3B_YEASTBRF1physical
16551611
RIC1_YEASTRIC1genetic
19061648
EFTU_YEASTTUF1genetic
19061648
CLU_YEASTCLU1genetic
19061648
SYKM_YEASTMSK1genetic
19061648
TF3B_YEASTBRF1physical
19086269
SUB1_YEASTSUB1physical
19706510
HMT1_YEASTHMT1physical
23268696
TF3B_YEASTBRF1physical
24277937
TFC4_YEASTTFC4physical
24277937
TBP_YEASTSPT15physical
24277937
MOD5_YEASTMOD5physical
23898186
TF3B_YEASTBRF1physical
26055328
RPC2_YEASTRET1physical
26055328
RPC5_YEASTRPC37physical
26055328
TFC3_YEASTTFC3genetic
27708008
LSM2_YEASTLSM2genetic
27708008
ALG14_YEASTALG14genetic
27708008
TFC1_YEASTTFC1genetic
27708008
CKS1_YEASTCKS1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
POP7_YEASTPOP7genetic
27708008
TFC6_YEASTTFC6genetic
27708008
SYF1_YEASTSYF1genetic
27708008
TBP_YEASTSPT15genetic
27708008
COG3_YEASTCOG3genetic
27708008
CDC4_YEASTCDC4genetic
27708008
ACT_YEASTACT1genetic
27708008
TFC4_YEASTTFC4genetic
27708008
CDC12_YEASTCDC12genetic
27708008
RPC9_YEASTRPC17genetic
27708008
IF2A_YEASTSUI2genetic
27708008
KTHY_YEASTCDC8genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
BOS1_YEASTBOS1genetic
27708008
CDC91_YEASTGAB1genetic
27708008
BET5_YEASTBET5genetic
27708008
PRP24_YEASTPRP24genetic
27708008
CLP1_YEASTCLP1genetic
27708008
EI2BG_YEASTGCD1genetic
27708008
TFC8_YEASTTFC8genetic
27708008
PSB5_YEASTPRE2genetic
27708008
PRP4_YEASTPRP4genetic
27708008
RPC3_YEASTRPC82genetic
27708008
BL1S6_HUMANBLOC1S6physical
27107014
CACO1_HUMANCALCOCO1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TFC5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-73 AND SER-178,AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, AND MASSSPECTROMETRY.

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