| UniProt ID | HMT1_YEAST | |
|---|---|---|
| UniProt AC | P38074 | |
| Protein Name | Protein arginine N-methyltransferase 1 {ECO:0000303|PubMed:8647869} | |
| Gene Name | HMT1 {ECO:0000303|PubMed:8668183} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 348 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that catalyzes both the mono- and asymmetric (type I) dimethylation of the guanidino nitrogens of arginine residues in a variety of RNA-binding proteins such as heterogeneous nuclear ribonucleoproteins (hnRNPs) and small nuclear ribonucleoproteins (snRNPs). [PubMed: 8668183] | |
| Protein Sequence | MSKTAVKDSATEKTKLSESEQHYFNSYDHYGIHEEMLQDTVRTLSYRNAIIQNKDLFKDKIVLDVGCGTGILSMFAAKHGAKHVIGVDMSSIIEMAKELVELNGFSDKITLLRGKLEDVHLPFPKVDIIISEWMGYFLLYESMMDTVLYARDHYLVEGGLIFPDKCSIHLAGLEDSQYKDEKLNYWQDVYGFDYSPFVPLVLHEPIVDTVERNNVNTTSDKLIEFDLNTVKISDLAFKSNFKLTAKRQDMINGIVTWFDIVFPAPKGKRPVEFSTGPHAPYTHWKQTIFYFPDDLDAETGDTIEGELVCSPNEKNNRDLNIKISYKFESNGIDGNSRSRKNEGSYLMH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Acetylation | -MSKTAVKDSATEKT -CCCCCCCCCCCCCC | 43.43 | 24489116 | |
| 54 | Acetylation | RNAIIQNKDLFKDKI HCHHHCCCCCCCCCE | 39.16 | 24489116 | |
| 115 | Acetylation | KITLLRGKLEDVHLP HHHEECCCEECCCCC | 42.12 | 24489116 | |
| 221 | Acetylation | NVNTTSDKLIEFDLN CCCCCCCEEEEEECC | 51.65 | 24489116 | |
| 229 | Phosphorylation | LIEFDLNTVKISDLA EEEEECCCCCHHHHH | 30.39 | 24961812 | |
| 233 | Phosphorylation | DLNTVKISDLAFKSN ECCCCCHHHHHHHCC | 22.36 | 24961812 | |
| 238 | Acetylation | KISDLAFKSNFKLTA CHHHHHHHCCCEEEE | 38.59 | 24489116 | |
| 326 | Acetylation | LNIKISYKFESNGID CEEEEEEEEECCCCC | 35.55 | 24489116 | |
| 340 | Ubiquitination | DGNSRSRKNEGSYLM CCCCCCCCCCCCCCC | 61.67 | 23749301 | |
| 344 | Phosphorylation | RSRKNEGSYLMH--- CCCCCCCCCCCC--- | 14.65 | 22369663 | |
| 345 | Phosphorylation | SRKNEGSYLMH---- CCCCCCCCCCC---- | 20.92 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HMT1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HMT1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HMT1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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