LYS1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYS1_YEAST
• UniProt AC: P38998
• Protein Name: Saccharopine dehydrogenase [NAD(+), L-lysine-forming]
• Gene Name: LYS1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 373
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate..
• Protein Sequence: MAAVTLHLRAETKPLEARAALTPTTVKKLIAKGFKIYVEDSPQSTFNINEYRQAGAIIVPAGSWKTAPRDRIIIGLKEMPETDTFPLVHEHIQFAHCYKDQAGWQNVLMRFIKGHGTLYDLEFLENDQGRRVAAFGFYAGFAGAALGVRDWAFKQTHSDDEDLPAVSPYPNEKALVKDVTKDYKEALATGARKPTVLIIGALGRCGSGAIDLLHKVGIPDANILKWDIKETSRGGPFDEIPQADIFINCIYLSKPIAPFTNMEKLNNPNRRLRTVVDVSADTTNPHNPIPIYTVATVFNKPTVLVPTTAGPKLSVISIDHLPSLLPREASEFFSHDLLPSLELLPQRKTAPVWVRAKKLFDRHCARVKRSSRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVTLHLR ------CCEEEEEEE	15.61	-
5	Phosphorylation	---MAAVTLHLRAET ---CCEEEEEEEEEC	12.06	19823750
12	Phosphorylation	TLHLRAETKPLEARA EEEEEEECCCHHHHH	36.66	19823750
13	Ubiquitination	LHLRAETKPLEARAA EEEEEECCCHHHHHC	38.83	23749301
22	Phosphorylation	LEARAALTPTTVKKL HHHHHCCCHHHHHHH	17.54	19823750
24	Phosphorylation	ARAALTPTTVKKLIA HHHCCCHHHHHHHHH	38.70	19823750
25	Phosphorylation	RAALTPTTVKKLIAK HHCCCHHHHHHHHHC	31.37	19823750
35	Ubiquitination	KLIAKGFKIYVEDSP HHHHCCCEEEEECCC	41.62	17644757
65	Ubiquitination	IVPAGSWKTAPRDRI EEECCCCCCCCCCEE	36.18	24961812
77	Acetylation	DRIIIGLKEMPETDT CEEEEEEECCCCCCC	46.91	24489116
99	Ubiquitination	IQFAHCYKDQAGWQN HHHHHHCCCCCCHHH	49.08	17644757
113	Ubiquitination	NVLMRFIKGHGTLYD HHHHHHHHCCCEEEE	41.99	17644757
154	Ubiquitination	GVRDWAFKQTHSDDE CCCHHHCCCCCCCCC	46.68	17644757
156	Phosphorylation	RDWAFKQTHSDDEDL CHHHCCCCCCCCCCC	24.76	24961812
158	Phosphorylation	WAFKQTHSDDEDLPA HHCCCCCCCCCCCCC	50.58	24961812
167	Phosphorylation	DEDLPAVSPYPNEKA CCCCCCCCCCCCHHH	22.33	27214570
173	Acetylation	VSPYPNEKALVKDVT CCCCCCHHHHHHHHC	54.37	24489116
173	Ubiquitination	VSPYPNEKALVKDVT CCCCCCHHHHHHHHC	54.37	17644757
177	Ubiquitination	PNEKALVKDVTKDYK CCHHHHHHHHCHHHH	47.53	17644757
181	Ubiquitination	ALVKDVTKDYKEALA HHHHHHCHHHHHHHH	59.93	17644757
184	Ubiquitination	KDVTKDYKEALATGA HHHCHHHHHHHHCCC	46.79	17644757
193	Ubiquitination	ALATGARKPTVLIIG HHHCCCCCCEEEEEE	44.50	17644757
215	Ubiquitination	GAIDLLHKVGIPDAN HHHHHHHHCCCCCCC	41.97	17644757
225	Ubiquitination	IPDANILKWDIKETS CCCCCEEEEECCCCC	38.74	17644757
229	Ubiquitination	NILKWDIKETSRGGP CEEEEECCCCCCCCC	53.09	17644757
254	Ubiquitination	INCIYLSKPIAPFTN EEEEEECCCCCCCCC	37.54	17644757
264	Ubiquitination	APFTNMEKLNNPNRR CCCCCHHHHCCCCCC	45.83	17644757
300	Ubiquitination	TVATVFNKPTVLVPT EEEEECCCCEEEEEC	30.51	17644757
307	Phosphorylation	KPTVLVPTTAGPKLS CCEEEEECCCCCCEE	23.07	28889911
308	Phosphorylation	PTVLVPTTAGPKLSV CEEEEECCCCCCEEE	24.44	28889911
312	Ubiquitination	VPTTAGPKLSVISID EECCCCCCEEEEEEC	53.10	17644757
348	Ubiquitination	LELLPQRKTAPVWVR HHCCCCCCCCCHHHH	43.73	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LYS1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYS1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYS1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VDAC1_YEAST	POR1	physical	11805837
TAL1_YEAST	TAL1	physical	11805837
GCH1_YEAST	FOL2	physical	11805837
XPOT_YEAST	LOS1	genetic	3031485
PEX14_YEAST	PEX14	physical	11283351
GIS2_YEAST	GIS2	physical	18467557
RUP1_YEAST	RUP1	physical	18719252

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.