RUP1_YEAST - dbPTM
RUP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RUP1_YEAST
UniProt AC Q12242
Protein Name UBA domain-containing protein RUP1
Gene Name RUP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 671
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Modulates the activity of the RSP5 HECT ubiquitin-protein ligase through its mediation of the interaction between RSP5 and the deubiquitinase UBP2. Involved in regulation of cell wall homeostasis..
Protein Sequence MMDNQAVKSLLEMGIPHEVAVDALQRTGGNLEAAVNFIFSNELPEQAEMGEENDGSQPRISENKIVAGTKPCDVPNNGDQDIDMPDVSGVDVDYDDDEDITDERSGSNSTSGCRVTAQNYDRYSISETSIPPPSYSIVQHNEFKSNVGDPTVVLPLPLNSLIESYFGLFALLTAVYFPHVFLKPDFKDLNYRADWFKGSSFTEPKYRLAYCEAEDGSTTSEIVLASGPNEGLQPHLLWQLQKLISVVNTRKCERAFVSAKVFTSSLEPQLRSKLADSEHLYEVLPAFIKSLAVDLEMCPGIRDRETRSLFISSALHTPNKNEPPMETFLSLFHFLPEEYDSNLYKMFNVLLYPEEEEEEEDVIRGGEQEEARYVEPENTLKEVAPVLTILFNELETNTESVSLPNGVDIPLEFYPQLYTKQCKDQLIRHIISKRKQARTRSRCLLQEINELKSYQGKNISTILESTLAYLQTIPDDANNEAAKQIASLKDTLNSARAAKMEEYKDLASKLHGEWNLSHPETHIINTAKQLGLIENPYILTMAALSPYSYFIRSRNGAWSWIQSNTLGTEFKVKKCSSPSVVQEAIKHGTKYASETPLMFIYCEEGKIPTEEVVAEALKSNSGCLKFAEDDQNSLKTLRSQFFDGMGDPEQATNNINNGNDNDNDDDIDSDN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
56PhosphorylationMGEENDGSQPRISEN
CCCCCCCCCCCCCCC		39.6228889911
101PhosphorylationYDDDEDITDERSGSN
CCCCCCCCCCCCCCC		44.1028889911
107PhosphorylationITDERSGSNSTSGCR
CCCCCCCCCCCCCCE		28.9328889911
109PhosphorylationDERSGSNSTSGCRVT
CCCCCCCCCCCCEEE		26.1627214570
110PhosphorylationERSGSNSTSGCRVTA
CCCCCCCCCCCEEEE		33.1327214570
111PhosphorylationRSGSNSTSGCRVTAQ
CCCCCCCCCCEEEEC		35.4025752575
116PhosphorylationSTSGCRVTAQNYDRY
CCCCCEEEECCCCCC		11.8122369663
120PhosphorylationCRVTAQNYDRYSISE
CEEEECCCCCCCCCC		6.9622369663
123PhosphorylationTAQNYDRYSISETSI
EECCCCCCCCCCCCC		13.8822369663
124PhosphorylationAQNYDRYSISETSIP
ECCCCCCCCCCCCCC		22.1122369663
126PhosphorylationNYDRYSISETSIPPP
CCCCCCCCCCCCCCC		28.9622369663
128PhosphorylationDRYSISETSIPPPSY
CCCCCCCCCCCCCCC		25.7622369663
129PhosphorylationRYSISETSIPPPSYS
CCCCCCCCCCCCCCC		29.1022369663
134PhosphorylationETSIPPPSYSIVQHN
CCCCCCCCCCEEECC		36.9722369663
135PhosphorylationTSIPPPSYSIVQHNE
CCCCCCCCCEEECCC		14.2722369663
136PhosphorylationSIPPPSYSIVQHNEF
CCCCCCCCEEECCCC		22.1822369663
210PhosphorylationEPKYRLAYCEAEDGS
CCCEEEEEEECCCCC		8.7329688323
217PhosphorylationYCEAEDGSTTSEIVL
EEECCCCCCEEEEEE		40.6129688323
218PhosphorylationCEAEDGSTTSEIVLA
EECCCCCCEEEEEEE		39.6129688323
219PhosphorylationEAEDGSTTSEIVLAS
ECCCCCCEEEEEEEC		26.5129688323
220PhosphorylationAEDGSTTSEIVLASG
CCCCCCEEEEEEECC		25.9729688323
226PhosphorylationTSEIVLASGPNEGLQ
EEEEEEECCCCCCCC		51.0929688323
273AcetylationLEPQLRSKLADSEHL
CCHHHHHHHCCCHHH		41.0624489116
273UbiquitinationLEPQLRSKLADSEHL
CCHHHHHHHCCCHHH		41.0623749301
489UbiquitinationAKQIASLKDTLNSAR
HHHHHHHHHHHHHHH		46.2819722269
499UbiquitinationLNSARAAKMEEYKDL
HHHHHHHHHHHHHHH		45.9519722269
576PhosphorylationEFKVKKCSSPSVVQE
EEEEEECCCHHHHHH		54.9127017623
579PhosphorylationVKKCSSPSVVQEAIK
EEECCCHHHHHHHHH		36.5527017623
633PhosphorylationFAEDDQNSLKTLRSQ
CCCCCHHHHHHHHHH		26.1322369663
635UbiquitinationEDDQNSLKTLRSQFF
CCCHHHHHHHHHHHC		45.3823749301
639PhosphorylationNSLKTLRSQFFDGMG
HHHHHHHHHHCCCCC		34.1622369663
652PhosphorylationMGDPEQATNNINNGN
CCCHHHHHCCCCCCC		28.6122369663
669PhosphorylationDNDDDIDSDN-----
CCCCCCCCCC-----		39.1122369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RUP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RUP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RUP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NPR2_YEASTNPR2physical
10688190
HUA1_YEASTHUA1physical
10688190
RV167_YEASTRVS167physical
16554755
RSP5_YEASTRSP5physical
16554755
FRA1_YEASTFRA1physical
16554755
CDC73_YEASTCDC73physical
16554755
HDA1_YEASTHDA1physical
16554755
UBP2_YEASTUBP2physical
16429126
RSP5_YEASTRSP5physical
19165343
UBP2_YEASTUBP2physical
19165343
CCZ1_YEASTCCZ1genetic
20093466
SGF29_YEASTSGF29genetic
20093466
VMS1_YEASTVMS1genetic
20093466
UBC13_YEASTUBC13genetic
20093466
SSD1_YEASTSSD1genetic
20093466
PEX31_YEASTPEX31genetic
20093466
YIS7_YEASTYIR007Wgenetic
20093466
PHO84_YEASTPHO84genetic
20093466
VPS9_YEASTVPS9genetic
20093466
EOS1_YEASTEOS1genetic
20093466
COG6_YEASTCOG6genetic
20093466
FAP1_YEASTFAP1genetic
20093466
MAM3_YEASTMAM3genetic
20093466
YP162_YEASTYPL162Cgenetic
20093466
MEI5_YEASTMEI5genetic
20093466
GGPPS_YEASTBTS1genetic
20093466
FAP1_YEASTFAP1genetic
27708008
CCZ1_YEASTCCZ1genetic
27708008
SGF29_YEASTSGF29genetic
27708008
UBC13_YEASTUBC13genetic
27708008
SAC3_YEASTSAC3genetic
27708008
H2A1_YEASTHTA1genetic
27708008
GET2_YEASTGET2genetic
27708008
UBP3_YEASTUBP3genetic
27708008
RL22B_YEASTRPL22Bgenetic
27708008
MED20_YEASTSRB2genetic
27708008
PHO86_YEASTPHO86genetic
27708008
IXR1_YEASTIXR1genetic
27708008
LIPB_YEASTLIP2genetic
27708008
ARPC3_YEASTARC18genetic
27708008
VPS9_YEASTVPS9genetic
27708008
PHO84_YEASTPHO84genetic
27708008
TMA23_YEASTTMA23genetic
27708008
ELP6_YEASTELP6genetic
27708008
MDM12_YEASTMDM12genetic
27708008
YO024_YEASTYOL024Wgenetic
27708008
MAM3_YEASTMAM3genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RUP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56; SER-126 AND SER-129,AND MASS SPECTROMETRY.

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