DON1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DON1_YEAST
• UniProt AC: Q05610
• Protein Name: Donuts protein 1
• Gene Name: DON1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 365
• Subcellular Localization: Prospore membrane . Towards the end of meiosis I, or early stages of meiosis II, it forms circular structures above the meiotic plaque. As soon as an assembled prospore membrane is visible during meiosis II, it is detected at the leading edge, which
• Protein Description: Involved in the pathway that organizes the prospore membrane (PSM) during sporulation..
• Protein Sequence: MGKKNRKGKENNAAKTSFLKVENIKNTNSGLELPSQDYTNVEEKESSPKTDFPLITKEHVNTKTDSNILDYPTIGDLVSSVEKLCVLKELKIAFPEVDDTLIKAILIASQGVLEPAFNSLLYYSSPEENTDFALPMKPISVEDYSKINVSEILQREIFDDIEDEFSGQGINGSMVISKIESELSSLAEHIGNISTPGSNREVAESTRNVAVAEGHNTILSNEDSILKGKEKGKEEEKEKGEEKGVNSLKGAAVKVVAKSLKNNRIPVTVKRNEPSNNLFDVLNCDESEEEEEQDVETNTSNQERKNQGGNTEVPEAQRDSADRLPAKDDGGYKSAFGTDSCGLFAADAKDEKKQVHPSRQELSFT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	KVENIKNTNSGLELP EEECCCCCCCCCCCC	26.26	27214570
29	Phosphorylation	ENIKNTNSGLELPSQ ECCCCCCCCCCCCCC	42.59	27214570
46	Phosphorylation	TNVEEKESSPKTDFP CCHHHCCCCCCCCCC	64.11	24961812
47	Phosphorylation	NVEEKESSPKTDFPL CHHHCCCCCCCCCCE	31.35	25752575
50	Phosphorylation	EKESSPKTDFPLITK HCCCCCCCCCCEECH	46.38	21440633
100	Phosphorylation	AFPEVDDTLIKAILI CCCCCCHHHHHHHHH	26.39	27214570
150	Phosphorylation	DYSKINVSEILQREI HHHHCCHHHHHHHHC	17.90	27214570
287	Phosphorylation	DVLNCDESEEEEEQD ECCCCCCCHHHHHHC	36.74	21440633
297	Phosphorylation	EEEQDVETNTSNQER HHHHCCCCCCCHHHH	43.58	21551504

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DON1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DON1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DON1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADY3_YEAST	ADY3	physical	27477278

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.