| UniProt ID | HST3_YEAST | |
|---|---|---|
| UniProt AC | P53687 | |
| Protein Name | NAD-dependent histone deacetylase HST3 | |
| Gene Name | HST3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 447 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | NAD-dependent histone deacetylase, which contributes together with HST4 to histone H3 'Lys-56' deacetylation, regulation of telomeric silencing, proper cell cycle progression, DNA damage control, DNA recombination, and genomic maintenance.. | |
| Protein Sequence | MTSVSPSPPASRSGSMCSDLPSSLQTEKLAHIIGLDADDEVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDCSQYWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRRGELPLCPDCEALINKRLNEGKRTLGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFLIIMGTSLKVDGVKQLVKKLSKKIHDRGGLIILVNKTPIGESSWHGIIDYQIHSDCDNWVTFLESQIPDFFKTQDQIKKLRQLKREASDLRKQMKAQKDSIGTPPTTPLRTAQGIDIQGNNELNTKIKSLNTVKRKILSPENSSEEDEEENLDTRKRAKIRPTFGDNQAS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 94 | Phosphorylation | SQYWSIKSGREMFDI HHCEEECCCCCEEEE | 41.22 | 21551504 | |
| 111 | Phosphorylation | FRDDFKISIFAKFME CCCCHHHHHHHHHHH | 16.55 | 21551504 | |
| 128 | Ubiquitination | YSNVQLAKPTKTHKF HHHCCCCCCCCCCCH | 62.91 | 17644757 | |
| 131 | Ubiquitination | VQLAKPTKTHKFIAH CCCCCCCCCCCHHHH | 58.10 | 17644757 | |
| 229 | Ubiquitination | DCEALINKRLNEGKR CHHHHHHHHHHCCCC | 51.79 | 17644757 | |
| 377 | Phosphorylation | QMKAQKDSIGTPPTT HHHHHHHCCCCCCCC | 29.92 | 20377248 | |
| 380 | Phosphorylation | AQKDSIGTPPTTPLR HHHHCCCCCCCCCCC | 25.15 | 20377248 | |
| 383 | Phosphorylation | DSIGTPPTTPLRTAQ HCCCCCCCCCCCCCC | 42.10 | 21440633 | |
| 384 | Phosphorylation | SIGTPPTTPLRTAQG CCCCCCCCCCCCCCC | 26.54 | 23749301 | |
| 406 | Phosphorylation | ELNTKIKSLNTVKRK HHHHHHHHHHHHHHH | 30.26 | 21126336 | |
| 416 | Phosphorylation | TVKRKILSPENSSEE HHHHHHCCCCCCCHH | 33.37 | 23749301 | |
| 420 | Phosphorylation | KILSPENSSEEDEEE HHCCCCCCCHHHHHH | 37.15 | 23749301 | |
| 421 | Phosphorylation | ILSPENSSEEDEEEN HCCCCCCCHHHHHHC | 57.49 | 21440633 | |
| 431 | Phosphorylation | DEEENLDTRKRAKIR HHHHCCCHHHHHHCC | 41.05 | 19823750 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HST3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HST3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HST3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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