RT105_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RT105_YEAST
• UniProt AC: P40063
• Protein Name: Regulator of Ty1 transposition protein 105
• Gene Name: RTT105
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 208
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Involved in regulation of Ty1 transposition. Inhibits Ty1 transposition at a post-transcriptional and pre-integrational stage of the Ty1 retrotransposition cycle..
• Protein Sequence: MYSNHNLNSDDCCFDWNEEKAAELQRTGVSFDRSLTPQSLRTSTRRLSEENKQQSGTMHIDTSPSVVSDIISSRRDRSQDFFGPHSSSPIAPSERQRADQRSRLESMRLTRRRDKMTKVRGGLEKMEEMIMQGEHLREMQRLKQEAQKNALPSDMAEYMEWQNNEDLEDDELLAFIEKQETYKNELEHFLNNANKNVYENNSYPNSHT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	YSNHNLNSDDCCFDW CCCCCCCCCCCCCCC	37.68	21440633
30	Phosphorylation	ELQRTGVSFDRSLTP HHHHHCCCCCCCCCH	23.83	22369663
36	Phosphorylation	VSFDRSLTPQSLRTS CCCCCCCCHHHHHHH	22.11	22369663
39	Phosphorylation	DRSLTPQSLRTSTRR CCCCCHHHHHHHHHH	22.48	22369663
48	Phosphorylation	RTSTRRLSEENKQQS HHHHHHHCHHHHHHC	40.84	20377248
55	Phosphorylation	SEENKQQSGTMHIDT CHHHHHHCCCEECCC	33.46	19779198
62	Phosphorylation	SGTMHIDTSPSVVSD CCCEECCCCHHHHHH	41.77	27017623
63	Phosphorylation	GTMHIDTSPSVVSDI CCEECCCCHHHHHHH	16.07	28889911
65	Phosphorylation	MHIDTSPSVVSDIIS EECCCCHHHHHHHHH	34.61	27017623
72	Phosphorylation	SVVSDIISSRRDRSQ HHHHHHHHCCCCCCC	20.37	30377154
78	Phosphorylation	ISSRRDRSQDFFGPH HHCCCCCCCCCCCCC	38.09	22369663
86	Phosphorylation	QDFFGPHSSSPIAPS CCCCCCCCCCCCCCC	35.33	22369663
87	Phosphorylation	DFFGPHSSSPIAPSE CCCCCCCCCCCCCCH	36.78	22369663
88	Phosphorylation	FFGPHSSSPIAPSER CCCCCCCCCCCCCHH	24.28	22369663
93	Phosphorylation	SSSPIAPSERQRADQ CCCCCCCCHHHHHHH	36.07	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RT105_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RT105_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RT105_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD55_YEAST	RAD55	genetic	17314980
DCC1_YEAST	DCC1	genetic	17314980
RAD9_YEAST	RAD9	genetic	17314980
RAD61_YEAST	RAD61	genetic	17314980
BIM1_YEAST	BIM1	genetic	17314980

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-88, AND MASSSPECTROMETRY.
PubMed: 18407956