| UniProt ID | CIK1_YEAST | |
|---|---|---|
| UniProt AC | Q01649 | |
| Protein Name | Spindle pole body-associated protein CIK1 | |
| Gene Name | CIK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 594 | |
| Subcellular Localization | Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. | |
| Protein Description | A developmentally regulated protein important for microtubule functions. Targets KAR3 to the cytoplasmic microtubules during mating. Essential for KAR3 function during prophase of meiosis I. Required for interhomolog recombination, synapsis of homologous chromosomes and establishment of a meiosis I spindle.. | |
| Protein Sequence | MNNSKIPKLSFHSDPNNVTRDFPKTKRQKVQKREMDMILTPNNNKLNILHSSGSGIRRCYTDDTSATYTKKLTFGGDPKIIERVKNNERKVRKDIDSLLNAISEIEKESVRIHARELPAITLELDAKVKACRELQNEIDGLSTEMDLKDNQCDLQRKNVELSSKNIVSMHAVKVQEFENDLEEELSNAKREWTYKLMEVENLKPDERLTDEMRQLKTEFEEVNRKLFILQNENENECKNYKKELDKKFEIFKKVKNDARIELDGEQERLSKVLKDLQDTHGELKENIKTCRDEFNDFEKRIGEAEVNFHSMELAVVPLKKKLASTSQALTQVQEEKKQVEGEANNWKKKYVNELEKVQQELYTRQNLATSIEEIKGYTRCFAYANERQMPDEFHINYVDRCICENSGEKRVQVFDRVVLEEIHKDHKRLYNECIPFLEKYISKLINCSIIVVSQQPTAPMKKTLLKQLIEQYGENYKMTLNILHLDGSIKHSDVGLDNPTEIRDLSQDEECMNILTLDTKLGKDEESHSMNIYIGSMSTVQLNRELDDAPSVLSHILTKTKQCFVFKINAGENIEKALALAGKLKRTITLPQLD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MNNSKIPKLSF ----CCCCCCCCCCC | 27.27 | 30377154 | |
| 10 | Phosphorylation | NSKIPKLSFHSDPNN CCCCCCCCCCCCCCC | 27.34 | 30377154 | |
| 51 | Phosphorylation | NKLNILHSSGSGIRR CCEEEEEECCCCCCE | 32.71 | 28889911 | |
| 52 | Phosphorylation | KLNILHSSGSGIRRC CEEEEEECCCCCCEE | 26.65 | 28889911 | |
| 54 | Phosphorylation | NILHSSGSGIRRCYT EEEEECCCCCCEEEC | 32.75 | 28889911 | |
| 61 | Phosphorylation | SGIRRCYTDDTSATY CCCCEEECCCCCCEE | 30.90 | 30377154 | |
| 64 | Phosphorylation | RRCYTDDTSATYTKK CEEECCCCCCEEEEE | 24.07 | 30377154 | |
| 65 | Phosphorylation | RCYTDDTSATYTKKL EEECCCCCCEEEEEE | 26.13 | 30377154 | |
| 67 | Phosphorylation | YTDDTSATYTKKLTF ECCCCCCEEEEEEEC | 31.33 | 30377154 | |
| 68 | Phosphorylation | TDDTSATYTKKLTFG CCCCCCEEEEEEECC | 19.11 | 30377154 | |
| 69 | Phosphorylation | DDTSATYTKKLTFGG CCCCCEEEEEEECCC | 19.83 | 30377154 | |
| 168 | Phosphorylation | LSSKNIVSMHAVKVQ CCCCCEEEEEEEEHH | 10.89 | 27017623 | |
| 369 | Phosphorylation | YTRQNLATSIEEIKG HHHHHHHHHHHHHHH | 33.14 | 22890988 | |
| 370 | Phosphorylation | TRQNLATSIEEIKGY HHHHHHHHHHHHHHH | 23.54 | 22890988 | |
| 506 | Phosphorylation | PTEIRDLSQDEECMN CCHHHCCCCCHHHHH | 39.62 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CIK1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CIK1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CIK1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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