MAD3_YEAST - dbPTM
MAD3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAD3_YEAST
UniProt AC P47074
Protein Name Spindle assembly checkpoint component MAD3
Gene Name MAD3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 515
Subcellular Localization Nucleus.
Protein Description Component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Component of the mitotic checkpoint complex (MCC) which inhibits the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20..
Protein Sequence MKAYAKKRISYMPSSPSQNVINFEEIETQKENILPLKEGRSAAALSKAIHQPLVEINQVKSSFEQRLIDELPALSDPITLYLEYIKWLNNAYPQGGNSKQSGMLTLLERCLSHLKDLERYRNDVRFLKIWFWYIELFTRNSFMESRDIFMYMLRNGIGSELASFYEEFTNLLIQKEKFQYAVKILQLGIKNKARPNKVLEDRLNHLLRELGENNIQLGNEISMDSLESTVLGKTRSEFVNRLELANQNGTSSDVNLTKNNVFVDGEESDVELFETPNRGVYRDGWENFDLKAERNKENNLRISLLEANTNLGELKQHEMLSQKKRPYDEKLPIFRDSIGRSDPVYQMINTKDQKPEKIDCNFKLIYCEDEESKGGRLEFSLEEVLAISRNVYKRVRTNRKHPREANLGQEESANQKEAEAQSKRPKISRKALVSKSLTPSNQGRMFSGEEYINCPMTPKGRSTETSDIISAVKPRQLTPILEMRESNSFSQSKNSEIISDDDKSSSSFISYPPQR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationAYAKKRISYMPSSPS
CHHCCCCCCCCCCCC		21.2928889911
14PhosphorylationKRISYMPSSPSQNVI
CCCCCCCCCCCCCCC		38.0521082442
15PhosphorylationRISYMPSSPSQNVIN
CCCCCCCCCCCCCCC		23.7728889911
250PhosphorylationELANQNGTSSDVNLT
HHHHHCCCCCCCCCC		32.3827017623
252PhosphorylationANQNGTSSDVNLTKN
HHHCCCCCCCCCCCC		45.4728889911
268PhosphorylationVFVDGEESDVELFET
EEECCCCCCEEEEEC		42.5328152593
303PhosphorylationKENNLRISLLEANTN
HHCCEEEEEEHHCCC		22.0717563356
337PhosphorylationKLPIFRDSIGRSDPV
CCCCCHHCCCCCCCC		23.7628889911
430AcetylationKRPKISRKALVSKSL
CCCCCCHHHHHCCCC		39.0025381059
435AcetylationSRKALVSKSLTPSNQ
CHHHHHCCCCCCCCC		41.8425381059
470PhosphorylationTETSDIISAVKPRQL
CCHHHHHHHCCHHHC		27.6123749301
478PhosphorylationAVKPRQLTPILEMRE
HCCHHHCHHHHHHHC		10.4325752575
486PhosphorylationPILEMRESNSFSQSK
HHHHHHCCCCCCCCC		27.6628889911
488PhosphorylationLEMRESNSFSQSKNS
HHHHCCCCCCCCCCC		35.2425752575
490PhosphorylationMRESNSFSQSKNSEI
HHCCCCCCCCCCCCC		33.1128889911
499PhosphorylationSKNSEIISDDDKSSS
CCCCCCCCCCCCCCC		40.4222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAD3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAD3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAD3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BUB3_YEASTBUB3physical
10704439
CDC20_YEASTCDC20physical
10704439
MAD2_YEASTMAD2physical
15879521
CIN8_YEASTCIN8genetic
10353895
MPS2_YEASTMPS2genetic
10353895
TBB_YEASTTUB2genetic
10353895
NOP56_YEASTNOP56genetic
15365764
CTF19_YEASTCTF19genetic
15249665
MCM21_YEASTMCM21genetic
15249665
CIN1_YEASTCIN1genetic
15249665
TBCC_YEASTCIN2genetic
15249665
PAC2_YEASTPAC2genetic
15249665
TBA3_YEASTTUB3genetic
15249665
PFD2_YEASTGIM4genetic
15249665
BIM1_YEASTBIM1genetic
15249665
KAR3_YEASTKAR3genetic
15249665
BIM1_YEASTBIM1genetic
16157669
CIK1_YEASTCIK1genetic
16157669
MED9_YEASTCSE2genetic
16157669
CTF18_YEASTCTF18genetic
16157669
CTF19_YEASTCTF19genetic
16157669
KAR3_YEASTKAR3genetic
16157669
MCK1_YEASTMCK1genetic
16157669
RIM13_YEASTRIM13genetic
16157669
HAL4_YEASTSAT4genetic
16157669
SIC1_YEASTSIC1genetic
16157669
BIM1_YEASTBIM1genetic
17314980
CIN8_YEASTCIN8genetic
17314980
PFD2_YEASTGIM4genetic
17314980
EAF1_YEASTEAF1genetic
17314980
SAC3_YEASTSAC3genetic
17314980
ARO1_YEASTARO1genetic
17314980
CTF8_YEASTCTF8genetic
17314980
BUB3_YEASTBUB3physical
17227844
CDC20_YEASTCDC20physical
17369399
BUB3_YEASTBUB3physical
17406666
CDC20_YEASTCDC20physical
17406666
MAD2_YEASTMAD2physical
17406666
CDC20_YEASTCDC20genetic
19339280
FUN30_YEASTFUN30genetic
20093466
H4_YEASTHHF1genetic
20093466
YPK3_YEASTYPK3genetic
20093466
AIM4_YEASTAIM4genetic
20093466
TXTP_YEASTCTP1genetic
20093466
HCM1_YEASTHCM1genetic
20093466
FUB1_YEASTFUB1genetic
20093466
THI3_YEASTTHI3genetic
20093466
MCM21_YEASTMCM21genetic
20093466
EAF1_YEASTEAF1genetic
20093466
PFD6_YEASTYKE2genetic
20093466
CIK1_YEASTCIK1genetic
20093466
RAS2_YEASTRAS2genetic
20093466
RCF2_YEASTRCF2genetic
20093466
CIN1_YEASTCIN1genetic
20093466
TBCC_YEASTCIN2genetic
20093466
MRX11_YEASTYPL041Cgenetic
20093466
CTF19_YEASTCTF19genetic
20093466
KAR3_YEASTKAR3genetic
20093466
SGF11_YEASTSGF11genetic
20959818
BUB1_YEASTBUB1genetic
20959818
PFD1_YEASTPFD1genetic
20959818
ZAP1_YEASTZAP1genetic
20959818
PFD2_YEASTGIM4genetic
20959818
MBF1_YEASTMBF1genetic
20959818
SPT3_YEASTSPT3genetic
20959818
SEF1_YEASTSEF1genetic
20959818
IME1_YEASTIME1genetic
20959818
SSN3_YEASTSSN3genetic
20959818
ASG1_YEASTASG1genetic
20959818
SAC3_YEASTSAC3genetic
20959818
YPT6_YEASTYPT6genetic
20959818
CIN8_YEASTCIN8genetic
19339280
PYRX_YEASTURA10genetic
27708008
MTW1_YEASTMTW1genetic
27708008
STU1_YEASTSTU1genetic
27708008
MPS1_YEASTMPS1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
SPC19_YEASTSPC19genetic
27708008
DUO1_YEASTDUO1genetic
27708008
NU145_YEASTNUP145genetic
27708008
OKP1_YEASTOKP1genetic
27708008
SPC97_YEASTSPC97genetic
27708008
DSN1_YEASTDSN1genetic
27708008
STS1_YEASTSTS1genetic
27708008
DAD2_YEASTDAD2genetic
27708008
IMB1_YEASTKAP95genetic
27708008
NOP2_YEASTNOP2genetic
27708008
SGT1_YEASTSGT1genetic
27708008
FUN30_YEASTFUN30genetic
27708008
URA7_YEASTURA7genetic
27708008
NU170_YEASTNUP170genetic
27708008
H4_YEASTHHF1genetic
27708008
YPK3_YEASTYPK3genetic
27708008
SEC66_YEASTSEC66genetic
27708008
BUD31_YEASTBUD31genetic
27708008
HCM1_YEASTHCM1genetic
27708008
FUB1_YEASTFUB1genetic
27708008
THI3_YEASTTHI3genetic
27708008
MCM21_YEASTMCM21genetic
27708008
YBP2_YEASTYBP2genetic
27708008
MRM2_YEASTMRM2genetic
27708008
PFD6_YEASTYKE2genetic
27708008
RAS2_YEASTRAS2genetic
27708008
CIN1_YEASTCIN1genetic
27708008
CTF19_YEASTCTF19genetic
27708008
MRX11_YEASTYPL041Cgenetic
27708008
HSP7F_YEASTSSE1genetic
27708008
TBCC_YEASTCIN2genetic
27708008
KAR3_YEASTKAR3genetic
27708008
PSH1_YEASTPSH1genetic
26891228
UBR2_YEASTUBR2genetic
26891228
BUB1_YEASTBUB1physical
27618268
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAD3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-488, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-478, AND MASSSPECTROMETRY.

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