LRG1_YEAST - dbPTM
LRG1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LRG1_YEAST
UniProt AC P35688
Protein Name Rho-GTPase-activating protein LRG1
Gene Name LRG1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1017
Subcellular Localization Cytoplasm. Bud. Bud neck. Localized to the bud site during bud formation and at the bud neck during cytokinesis.
Protein Description Acts in signal transduction. Activates CDC42, RHO1 and RHO2. Negatively regulates 1,3-beta-glucan synthesis. May be responsible for the down-regulation of CDC42 during mating..
Protein Sequence MIQNSAGYRSLNTASPMTVQVKNQKKICARCNKLVIPDSQRTKTTLKALGKYYHESCFTCQDCQKPLKPKYFPYQVDKTSESILLCQYDYFRRHNLLCHVCDTPLRGLYYTAFGYRYDEEHFSCTICATPCGVKKCFMYGNQLYCKYHFLKYFSKRCKGCEFPISDQYIEFPKGEEIHCWHPECYGIHKYWHVNLAAETVGLQYLPKLEYNPNSGDKDINPTAYELDKQMQAFNFILSKTWSVLYRFEEEAASCISDMFQYLTSNDQLKGIESTGLLVLKIDCLFRGLDTLNLSTNKSMPVNSDQECIENNAMAASKYSKFPKNLSTKIMIYLQLLRKLGTENKNETITISSFMSVITGLAHFLKLLTRFGLYTALENNKLTHSVNPLLRFLREVEKNELFENNPFQYIKTPVNATDSCAGCNKYIQEECIQFYEHRWHIACFTCSSCHKNINPRSLTDPTFNKEKKKILCSHCSIDDPASVPGFKFVTKLAQLIFLLKIALVKSRTVMLKSKASNKVGRNSLQSTMLKEQTYIRTLNDIKRLRSRRESVRVTHNKQQARKSVILETAETDLNDPTKQGDSKNLVIQTDDPSSSQQVSTRENVFSNTKTLTLDDISRIVAAEQARELRPNAFAHFKKLKETDDETSNVVPKKSGVYYSELSTMELSMIRAISLSLLAGKQLISKTDPNYTSLVSMVFSNEKQVTGSFWNRMKIMMSMEPKKPITKTVFGAPLDVLCEKWGVDSDLGVGPVKIRIPIIIDELISSLRQMDMSVEGIFRKNGNIRRLRELTANIDSNPTEAPDFSKENAIQLSALLKKFIRELPQPILSTDLYELWIKAAKIDLEDEKQRVILLIYSLLPTYNRNLLEALLSFLHWTSSFSYIENEMGSKMDIHNLSTVITPNILYLRHKEISNDNVPDEPESGLVDSFAQNKGENYFLAIEIVDYLITHNEEMAMVPKFLMNLLKDVQLQKLDNYESINHFISTVMQSKTIDYSECDIKTPVTVKDSTTTVIQGEINK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MIQNSAGY
-------CCCCCCCC		33.3022814378
15PhosphorylationYRSLNTASPMTVQVK
CCCCCCCCCCEEEEC		17.1122369663
18PhosphorylationLNTASPMTVQVKNQK
CCCCCCCEEEECCHH		15.9222369663
269AcetylationLTSNDQLKGIESTGL
HCCCHHHCCHHHCCE		52.8125381059
303PhosphorylationNKSMPVNSDQECIEN
CCCCCCCCCHHHHHH		40.6923749301
512PhosphorylationSRTVMLKSKASNKVG
CCCCHHCCCCCCCCC		29.5027017623
515PhosphorylationVMLKSKASNKVGRNS
CHHCCCCCCCCCHHH		40.7027017623
522PhosphorylationSNKVGRNSLQSTMLK
CCCCCHHHHHHHHHH		26.8221440633
525PhosphorylationVGRNSLQSTMLKEQT
CCHHHHHHHHHHHHH		22.5221440633
526PhosphorylationGRNSLQSTMLKEQTY
CHHHHHHHHHHHHHH		17.3527017623
562PhosphorylationNKQQARKSVILETAE
CHHHHHHEEEEEEEC		14.6121551504
567PhosphorylationRKSVILETAETDLND
HHEEEEEEECCCCCC		26.7530377154
582UbiquitinationPTKQGDSKNLVIQTD
CCCCCCCCCEEEECC		60.0723749301
588PhosphorylationSKNLVIQTDDPSSSQ
CCCEEEECCCCCCCC		31.1130377154
593PhosphorylationIQTDDPSSSQQVSTR
EECCCCCCCCCCCCC		37.2423749301
605PhosphorylationSTRENVFSNTKTLTL
CCCCCCCCCCCEEEH		39.0324603354
607PhosphorylationRENVFSNTKTLTLDD
CCCCCCCCCEEEHHH		24.9826447709
609PhosphorylationNVFSNTKTLTLDDIS
CCCCCCCEEEHHHHH		23.9626447709
611PhosphorylationFSNTKTLTLDDISRI
CCCCCEEEHHHHHHH		33.1126447709
641PhosphorylationHFKKLKETDDETSNV
HHHHHHCCCCCCCCC		47.3527717283
645PhosphorylationLKETDDETSNVVPKK
HHCCCCCCCCCCCCC		32.3727017623
646PhosphorylationKETDDETSNVVPKKS
HCCCCCCCCCCCCCC		26.1123749301
771PhosphorylationSLRQMDMSVEGIFRK
HHHHCCCCHHHHHHC		16.8630377154
811PhosphorylationKENAIQLSALLKKFI
HHHHHHHHHHHHHHH		10.6530377154
895PhosphorylationKMDIHNLSTVITPNI
CEECCCHHHCCCCCE		26.4128889911
896PhosphorylationMDIHNLSTVITPNIL
EECCCHHHCCCCCEE		21.0628889911
974PhosphorylationQLQKLDNYESINHFI
CHHHCCCHHHHHHHH		15.6628889911
982PhosphorylationESINHFISTVMQSKT
HHHHHHHHHHHCCCC		17.6328889911
983PhosphorylationSINHFISTVMQSKTI
HHHHHHHHHHCCCCC		18.3828889911
987PhosphorylationFISTVMQSKTIDYSE
HHHHHHCCCCCCCCC		17.4228889911
993PhosphorylationQSKTIDYSECDIKTP
CCCCCCCCCCCCCCC		28.1823749301
998UbiquitinationDYSECDIKTPVTVKD
CCCCCCCCCCEEECC		33.2623749301
999PhosphorylationYSECDIKTPVTVKDS
CCCCCCCCCEEECCC		24.2723749301
1002PhosphorylationCDIKTPVTVKDSTTT
CCCCCCEEECCCCCE		24.0421551504
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LRG1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LRG1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LRG1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RHO1_YEASTRHO1physical
11713681
RHO1_YEASTRHO1physical
11447600
RHO1_YEASTRHO1physical
15514049
FUS2_YEASTFUS2genetic
15514049
RV161_YEASTRVS161genetic
15514049
FUS1_YEASTFUS1genetic
15514049
SPA2_YEASTSPA2genetic
15514049
TUS1_YEASTTUS1genetic
19339687
RHO1_YEASTRHO1physical
23878277
GAP1_YEASTGAP1genetic
27708008
FAL1_YEASTFAL1genetic
27708008
PDC2_YEASTPDC2genetic
27708008
CDC37_YEASTCDC37genetic
27708008
CDC1_YEASTCDC1genetic
27708008
FCF1_YEASTFCF1genetic
27708008
UTP5_YEASTUTP5genetic
27708008
COG3_YEASTCOG3genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
SMD1_YEASTSMD1genetic
27708008
MED6_YEASTMED6genetic
27708008
RRP4_YEASTRRP4genetic
27708008
STS1_YEASTSTS1genetic
27708008
ARP4_YEASTARP4genetic
27708008
KRE9_YEASTKRE9genetic
27708008
NUP85_YEASTNUP85genetic
27708008
SMC6_YEASTSMC6genetic
27708008
RNA1_YEASTRNA1genetic
27708008
CAP_YEASTSRV2genetic
27708008
PROF_YEASTPFY1genetic
27708008
IF6_YEASTTIF6genetic
27708008
DPM1_YEASTDPM1genetic
27708008
SLA1_YEASTSLA1genetic
27708008
QOR_YEASTZTA1genetic
27708008
SEC66_YEASTSEC66genetic
27708008
RV161_YEASTRVS161genetic
27708008
BUD31_YEASTBUD31genetic
27708008
RM01_YEASTMRPL1genetic
27708008
MNN10_YEASTMNN10genetic
27708008
PMP3_YEASTPMP3genetic
27708008
OMS1_YEASTOMS1genetic
27708008
RV167_YEASTRVS167genetic
27708008
SAC7_YEASTSAC7genetic
27708008
ERD1_YEASTERD1genetic
27708008
UBP3_YEASTUBP3genetic
27708008
CHAC_YEASTGCG1genetic
27708008
FIS1_YEASTFIS1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
HOC1_YEASTHOC1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
VPS24_YEASTVPS24genetic
27708008
DCW1_YEASTDCW1genetic
27708008
ELM1_YEASTELM1genetic
27708008
SFK1_YEASTSFK1genetic
27708008
RCN1_YEASTRCN1genetic
27708008
VPS51_YEASTVPS51genetic
27708008
UBX2_YEASTUBX2genetic
27708008
VPS9_YEASTVPS9genetic
27708008
VPS21_YEASTVPS21genetic
27708008
VAM3_YEASTVAM3genetic
27708008
MTHR1_YEASTMET12genetic
27708008
SUR1_YEASTSUR1genetic
27708008
KES1_YEASTKES1genetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LRG1_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-562, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory