DCW1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCW1_YEAST
• UniProt AC: P36091
• Protein Name: Mannan endo-1,6-alpha-mannosidase DCW1
• Gene Name: DCW1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 449
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor . GPI-anchored plasma membrane protein (GPI-PMP).
• Protein Description: Required for normal synthesis of the cell wall..
• Protein Sequence: MLVNKVIGLLGVLFATRFTNAVELDLDNYESLQNATSLIAYGLMDYYTGNQYGKTVGMFSDPYYWWEAGGAWGCMLDYWFFMDNDTYNDEIIAAMIHQAGDDNDYIPLNQSTTEGNDDQAFWGIAAMTAAERNFTNPPENEPQWLYLAQAVFNTMALRWDADSCGGGLRWQIFVWNSGYDYKNTVSNGALFHIAARLARYTGNQTYVDWAEKVYEWMVGVNLISNGTYKYVYDGVSIDDNCTKVTSYQWTYNQGLLLAGSAYLYNFTGSDLWHTRTKEFLNASQVFFHDGIVYEAACQGPNSCNTDQRSFKAYFARFLGVTAQLVPETRNQIMSWLNTSAIAAAKSCSGGTDGHTCGLNWFNGTWDGMYGLGEQMSALEVMVNTRALDKPAPYTAENGGSSVGDGAAGTQAQPTNLAPLNITKGSKAGAGIITAVIGISIVACALWLVF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	N-linked_Glycosylation	DNYESLQNATSLIAY CCHHHHHHHHHHHHH	50.94	-
84	N-linked_Glycosylation	DYWFFMDNDTYNDEI EEEEEECCCCCCHHH	31.56	-
109	N-linked_Glycosylation	DNDYIPLNQSTTEGN CCCEECCCCCCCCCC	28.53	-
133	N-linked_Glycosylation	AMTAAERNFTNPPEN HHHHHHHCCCCCCCC	39.33	-
203	N-linked_Glycosylation	RLARYTGNQTYVDWA HHHHHHCCCCCCHHH	24.18	-
224	Phosphorylation	MVGVNLISNGTYKYV HHCCEEEECCEEEEE	32.16	28889911
225	N-linked_Glycosylation	VGVNLISNGTYKYVY HCCEEEECCEEEEEE	39.57	-
228	Phosphorylation	NLISNGTYKYVYDGV EEEECCEEEEEECCE	11.17	29650682
240	N-linked_Glycosylation	DGVSIDDNCTKVTSY CCEEECCCCCEEEEE	31.45	-
265	N-linked_Glycosylation	AGSAYLYNFTGSDLW ECEEEEEECCCCCCC	25.96	-
281	N-linked_Glycosylation	TRTKEFLNASQVFFH CCCHHHHCHHHEEEC	42.75	-
337	N-linked_Glycosylation	NQIMSWLNTSAIAAA HHHHHHHCHHHHHHH	26.23	-
362	N-linked_Glycosylation	TCGLNWFNGTWDGMY CCCCCCCCCCCCCCC	38.30	-
400	Phosphorylation	YTAENGGSSVGDGAA CCCCCCCCCCCCCCC	24.21	28889911
401	Phosphorylation	TAENGGSSVGDGAAG CCCCCCCCCCCCCCC	33.13	28889911
420	N-linked_Glycosylation	PTNLAPLNITKGSKA CCCCCCCCCCCCCCC	38.53	-
428	GPI-anchor	ITKGSKAGAGIITAV CCCCCCCCCHHHHHH	28.24	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCW1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCW1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCW1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DFG5_YEAST	DFG5	genetic	12421307
OSTD_YEAST	SWP1	physical	18467557
SSB1_YEAST	SSB1	physical	22940862
HSP71_YEAST	SSA1	physical	22940862
DFG5_YEAST	DFG5	genetic	23891562
SLG1_YEAST	SLG1	genetic	23891562
TLG2_YEAST	TLG2	genetic	23891562
CCW12_YEAST	CCW12	genetic	23891562
MSMO_YEAST	ERG25	genetic	23891562
ELO3_YEAST	ELO3	genetic	23891562
ETR1_YEAST	ETR1	genetic	27708008
PUT4_YEAST	PUT4	genetic	27708008
FLC2_YEAST	FLC2	genetic	27708008
YJ66_YEAST	YJR096W	genetic	27708008
RT109_YEAST	RTT109	genetic	27708008
DFG5_YEAST	DFG5	genetic	27708008
STI1_YEAST	STI1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400 AND SER-401, ANDMASS SPECTROMETRY.
PubMed: 12872131