PUT4_YEAST - dbPTM
PUT4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUT4_YEAST
UniProt AC P15380
Protein Name Proline-specific permease
Gene Name PUT4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 627
Subcellular Localization Membrane
Multi-pass membrane protein.
Protein Description Required for high-affinity proline transport. May be responsible for proline recognition and probably also for proline translocation across the plasma membrane. Also function as non-specific GABA permease. Can also transport alanine and glycine..
Protein Sequence MVNILPFHKNNRHSAGVVTCADDVSGDGSGGDTKKEEDVVQVTESPSSGSRNNHRSDNEKDDAIRMEKISKNQSASSNGTIREDLIMDVDLEKSPSVDGDSEPHKLKQGLQSRHVQLIALGGAIGTGLLVGTSSTLHTCGPAGLFISYIIISAVIYPIMCALGEMVCFLPGDGSDSAGSTANLVTRYVDPSLGFATGWNYFYCYVILVAAECTAASGVVEYWTTAVPKGVWITIFLCVVVILNFSAVKVYGESEFWFASIKILCIVGLIILSFILFWGGGPNHDRLGFRYWQHPGAFAHHLTGGSLGNFTDIYTGIIKGAFAFILGPELVCMTSAECADQRRNIAKASRRFVWRLIFFYVLGTLAISVIVPYNDPTLVNALAQGKPGAGSSPFVIGIQNAGIKVLPHIINGCILTSAWSAANAFMFASTRSLLTMAQTGQAPKCLGRINKWGVPYVAVGVSFLCSCLAYLNVSSSTADVFNWFSNISTISGFLGWMCGCIAYLRFRKAIFYNGLYDRLPFKTWGQPYTVWFSLIVIGIITITNGYAIFIPKYWRVADFIAAYITLPIFLVLWFGHKLYTRTWRQWWLPVSEIDVTTGLVEIEEKSREIEEMRLPPTGFKDKFLDALL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationFHKNNRHSAGVVTCA
CCCCCCCCCCEEEEC		24.3928889911
19PhosphorylationRHSAGVVTCADDVSG
CCCCCEEEECCCCCC		10.2827717283
25PhosphorylationVTCADDVSGDGSGGD
EEECCCCCCCCCCCC		37.8528889911
29PhosphorylationDDVSGDGSGGDTKKE
CCCCCCCCCCCCCCC		44.3227717283
33PhosphorylationGDGSGGDTKKEEDVV
CCCCCCCCCCCCCEE		47.4927717283
45PhosphorylationDVVQVTESPSSGSRN
CEEEEECCCCCCCCC		22.2529734811
47PhosphorylationVQVTESPSSGSRNNH
EEEECCCCCCCCCCC		57.5228889911
56PhosphorylationGSRNNHRSDNEKDDA
CCCCCCCCCCHHHHH		36.9228889911
60UbiquitinationNHRSDNEKDDAIRME
CCCCCCHHHHHHHHH		68.1317644757
72N-linked_GlycosylationRMEKISKNQSASSNG
HHHHHCCCCCCCCCC		33.96-
78N-linked_GlycosylationKNQSASSNGTIREDL
CCCCCCCCCCCCCCE		49.48-
94PhosphorylationMDVDLEKSPSVDGDS
EEEECCCCCCCCCCC		17.0329734811
96PhosphorylationVDLEKSPSVDGDSEP
EECCCCCCCCCCCCC		39.6728889911
101PhosphorylationSPSVDGDSEPHKLKQ
CCCCCCCCCCHHHHH		59.5629688323
443UbiquitinationAQTGQAPKCLGRINK
HHHCCCCHHHCHHHC		45.1417644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUT4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUT4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTF1_YEASTMTF1physical
10688190
RRT12_YEASTRRT12physical
10688190
ALY2_YEASTALY2physical
10688190
HIR1_YEASTHIR1genetic
20093466
HCM1_YEASTHCM1genetic
20093466
QRI7_YEASTQRI7genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
STP1_YEASTSTP1genetic
20093466
VRP1_YEASTVRP1genetic
20093466
ECM38_YEASTECM38genetic
21623372
COX8_YEASTCOX8genetic
21623372
LCB5_YEASTLCB5genetic
21623372
GAL2_YEASTGAL2genetic
21623372
ATPK_YEASTATP17genetic
21623372
PYRD_YEASTURA1genetic
21623372
INP54_YEASTINP54genetic
21623372
SUCB_YEASTLSC2genetic
21623372
ATP14_YEASTATP14genetic
21623372
CDC12_YEASTCDC12genetic
27708008
MET30_YEASTMET30genetic
27708008
PSB6_YEASTPRE7genetic
27708008
PRP6_YEASTPRP6genetic
27708008
TECR_YEASTTSC13genetic
27708008
NOP14_YEASTNOP14genetic
27708008
PDC2_YEASTPDC2genetic
27708008
UTP5_YEASTUTP5genetic
27708008
TBP_YEASTSPT15genetic
27708008
ACT_YEASTACT1genetic
27708008
GPI10_YEASTGPI10genetic
27708008
TEL2_YEASTTEL2genetic
27708008
BRL1_YEASTBRL1genetic
27708008
ORC6_YEASTORC6genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
KTHY_YEASTCDC8genetic
27708008
RFC2_YEASTRFC2genetic
27708008
FNTA_YEASTRAM2genetic
27708008
CWC16_YEASTYJU2genetic
27708008
NTR2_YEASTNTR2genetic
27708008
SEC22_YEASTSEC22genetic
27708008
HAS1_YEASTHAS1genetic
27708008
DBP6_YEASTDBP6genetic
27708008
NUF2_YEASTNUF2genetic
27708008
MOT1_YEASTMOT1genetic
27708008
TBF1_YEASTTBF1genetic
27708008
DIB1_YEASTDIB1genetic
27708008
MTC4_YEASTMTC4genetic
27708008
RMD1_YEASTRMD1genetic
27708008
QRI7_YEASTQRI7genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
STP1_YEASTSTP1genetic
27708008
RIM15_YEASTRIM15genetic
27708008
RTS3_YEASTRTS3genetic
27708008
PTK2_YEASTPTK2genetic
27708008
ATG16_YEASTATG16genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUT4_YEAST

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Related Literatures of Post-Translational Modification

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