ATPK_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATPK_YEAST
• UniProt AC: Q06405
• Protein Name: ATP synthase subunit f, mitochondrial
• Gene Name: ATP17
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 101
• Subcellular Localization: Mitochondrion. Mitochondrion inner membrane.
• Protein Description: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane..
• Protein Sequence: MIFKRAVSTLIPPKVVSSKNIGSAPNAKRIANVVHFYKSLPQGPAPAIKANTRLARYKAKYFDGDNASGKPLWHFALGIIAFGYSMEYYFHLRHHKGAEEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Acetylation	PPKVVSSKNIGSAPN CCCCCCCCCCCCCCC	45.11	25381059
28	Succinylation	IGSAPNAKRIANVVH CCCCCCHHHHHHHHH	51.48	23954790
38	Acetylation	ANVVHFYKSLPQGPA HHHHHHHHCCCCCCC	44.57	24489116
49	Ubiquitination	QGPAPAIKANTRLAR CCCCCHHHHCHHHHH	37.38	24961812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATPK_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATPK_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATPK_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATP7_YEAST	ATP7	physical	10747812
ATP18_YEAST	ATP18	physical	10747812
DNM1_YEAST	DNM1	genetic	18445678

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.