MTHR1_YEAST - dbPTM
MTHR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTHR1_YEAST
UniProt AC P46151
Protein Name Methylenetetrahydrofolate reductase 1
Gene Name MET12
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 657
Subcellular Localization
Protein Description
Protein Sequence MSIRDLYHARASPFISLEFFPPKTELGTRNLMERMHRMTALDPLFITVTWGAGGTTAEKTLTLASLAQQTLNIPVCMHLTCTNTEKAIIDDALDRCYNAGIRNILALRGDPPIGEDWLDSQSNESPFKYAVDLVRYIKQSYGDKFCVGVAAYPEGHCEGEAEGHEQDPLKDLVYLKEKVEAGADFVITQLFYDVEKFLTFEMLFRERISQDLPLFPGLMPINSYLLFHRAAKLSHASIPPAILSRFPPEIQSDDNAVKSIGVDILIELIQEIYQRTSGRIKGFHFYTLNLEKAIAQIVSQSPVLSHIVNESSEEEGEDETSGEIGSIENVPIEDADGDIVLDDSNEETVANRKRRRHSSLDSAKLIFNRAIVTEKGLRYNNENGSMPSKKALISISKGHGTLGRDATWDEFPNGRFGDSRSPAYGEIDGYGPSIKVSKSKALELWGIPKTIGDLKDIFIKYLEGSTDAIPWSDLGLSAETALIQEELIQLNYRGYLTLASQPATNATLSSDKIFGWGPAKGRLYQKAFVEMFIHRQQWETTLKPKLDHYGRRKFSYYAGDSSGSFETNLDPHSSSVVTWGVFPNSPVKQTTIIEEESFKAWRDEAFSIWSEWAKLFPRNTPANILLRLVHKDYCLVSIVHHDFKETDELWEMLLDQA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
39PhosphorylationMERMHRMTALDPLFI
HHHHHHHHHCCCEEE		24.8319779198
49PhosphorylationDPLFITVTWGAGGTT
CCEEEEEEECCCCCH		14.9919779198
56PhosphorylationTWGAGGTTAEKTLTL
EECCCCCHHHHHHHH		35.7719779198
120PhosphorylationIGEDWLDSQSNESPF
CCCCCCCCCCCCCHH		33.0820190278
122PhosphorylationEDWLDSQSNESPFKY
CCCCCCCCCCCHHHH		46.6630377154
136PhosphorylationYAVDLVRYIKQSYGD
HHHHHHHHHHHHHCC		12.6530377154
140PhosphorylationLVRYIKQSYGDKFCV
HHHHHHHHHCCCEEE		26.5330377154
141PhosphorylationVRYIKQSYGDKFCVG
HHHHHHHHCCCEEEE		27.1830377154
301PhosphorylationIAQIVSQSPVLSHIV
HHHHHHCCHHHHHHC		14.9628889911
358PhosphorylationNRKRRRHSSLDSAKL
HHHHHCCCCHHHHHH		30.6821082442
359PhosphorylationRKRRRHSSLDSAKLI
HHHHCCCCHHHHHHH		30.0321082442
362PhosphorylationRRHSSLDSAKLIFNR
HCCCCHHHHHHHHHH		32.3719795423
394PhosphorylationPSKKALISISKGHGT
CCHHEEEEEECCCCC		22.9730377154
396PhosphorylationKKALISISKGHGTLG
HHEEEEEECCCCCCC		26.2930377154
407PhosphorylationGTLGRDATWDEFPNG
CCCCCCCCCCCCCCC		37.4228889911
455AcetylationPKTIGDLKDIFIKYL
CCCHHHHHHHHHHHH		54.2224489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTHR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTHR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTHR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MTHR2_YEASTMET13physical
16429126
HSP71_YEASTSSA1physical
19536198
DPB3_YEASTDPB3genetic
20093466
RL35A_YEASTRPL35Agenetic
20093466
RL35B_YEASTRPL35Agenetic
20093466
PALF_YEASTRIM8genetic
20093466
YG036_YEASTYGL036Wgenetic
20093466
RTS3_YEASTRTS3genetic
20093466
AP18B_YEASTYAP1802genetic
20093466
MALX3_YEASTIMA1genetic
20093466
RIM4_YEASTRIM4genetic
20093466
YHB7_YEASTYHL017Wgenetic
20093466
CTM1_YEASTCTM1genetic
20093466
CRP1_YEASTCRP1genetic
20093466
LIN1_YEASTLIN1genetic
20093466
TDA11_YEASTTDA11genetic
20093466
SSP1_YEASTSSP1genetic
20093466
PIG2_YEASTPIG2genetic
20093466
SFGH_YEASTYJL068Cgenetic
20093466
YJ24_YEASTKCH1genetic
20093466
SOK2_YEASTSOK2genetic
20093466
PALI_YEASTRIM9genetic
20093466
NST1_YEASTNST1genetic
20093466
HDA1_YEASTHDA1genetic
20093466
MED9_YEASTCSE2genetic
20093466
ARE2_YEASTARE2genetic
20093466
WHI5_YEASTWHI5genetic
20093466
MTHR2_YEASTMET13physical
20826334
CSG2_YEASTCSG2genetic
21623372
ARO1_YEASTARO1genetic
21623372
LCB5_YEASTLCB5genetic
21623372
CRP1_YEASTCRP1genetic
27708008
ICE2_YEASTICE2genetic
27708008
ETR1_YEASTETR1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
RPN4_YEASTRPN4genetic
27708008
RL35A_YEASTRPL35Agenetic
27708008
RL35B_YEASTRPL35Agenetic
27708008
FCY2_YEASTFCY2genetic
27708008
UBP3_YEASTUBP3genetic
27708008
PALF_YEASTRIM8genetic
27708008
ASK10_YEASTASK10genetic
27708008
RTS3_YEASTRTS3genetic
27708008
AP18B_YEASTYAP1802genetic
27708008
CTM1_YEASTCTM1genetic
27708008
LIN1_YEASTLIN1genetic
27708008
SSP1_YEASTSSP1genetic
27708008
PIG2_YEASTPIG2genetic
27708008
YJ24_YEASTKCH1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
MSC1_YEASTMSC1genetic
27708008
SOK2_YEASTSOK2genetic
27708008
ELP6_YEASTELP6genetic
27708008
NST1_YEASTNST1genetic
27708008
PALA_YEASTRIM20genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTHR1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-301; SER-358;SER-359 AND THR-407, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-358 AND SER-359, ANDMASS SPECTROMETRY.

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