MALX3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MALX3_YEAST
• UniProt AC: P53051
• Protein Name: Oligo-1,6-glucosidase IMA1
• Gene Name: IMA1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 589
• Subcellular Localization: Mitochondrion .
• Protein Description: Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization. Preferentially hydrolyzes isomaltose, palatinose, and methyl-alpha-glucoside, with little activity towards isomaltotriose or longer oligosaccharides. Does not hydrolyze maltose..
• Protein Sequence: MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
285	Phosphorylation	MQHASDETKRLYTSA EEECCHHHHHHHHHH	26.84	27017623
366	Ubiquitination	RFGDDSPKNRVISGK ECCCCCCCCCCCCHH	62.43	23749301
447	Phosphorylation	ISRDHARTPMQWSRE HCCCCCCCCCCCCCC	24.72	29136822

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MALX3_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MALX3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MALX3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THRC_YEAST	THR4	genetic	21623372
QCR7_YEAST	QCR7	genetic	21623372
COQ7_YEAST	CAT5	genetic	21623372
OS9_YEAST	YOS9	genetic	27708008
BUD21_YEAST	BUD21	genetic	27708008
GRP75_HUMAN	HSPA9	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.