CHAC_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHAC_YEAST
• UniProt AC: P32656
• Protein Name: Glutathione-specific gamma-glutamylcyclotransferase {ECO:0000305|PubMed:23070364}
• Gene Name: GCG1 {ECO:0000303|PubMed:23070364}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 232
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Allows utilization of gluthathione through subsequent cleavage of the Cys-Gly dipeptide by Cys-Gly metallodipeptidase DUG1..
• Protein Sequence: MTNDNSGIWVLGYGSLIYKPPSHYTHRIPAIIHGFARRFWQSSTDHRGTPANPGRVATLIPYEDIIRQTAFLKNVNLYSESAPIQDPDDLVTIGVVYYIPPEHAQEVREYLNVREQNGYTLHEVEVHLETNREHEAELGEALEQLPRHNKSGKRVLLTSVYIGTIDNEAFVGPETVDETAKVIAVSHGPSGSNYEYLAKLEQALAQMPIMKERGRITDHYLTALLETVNKYR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	SGIWVLGYGSLIYKP CCEEEEECCEEEECC	10.20	28132839
211	Ubiquitination	LAQMPIMKERGRITD HHCCCCHHHCCCCCH	45.00	23749301
222	Phosphorylation	RITDHYLTALLETVN CCCHHHHHHHHHHHH	14.21	19779198

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHAC_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHAC_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHAC_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPS8_YEAST	VPS8	genetic	27708008
DSF2_YEAST	DSF2	genetic	27708008
RS27B_YEAST	RPS27B	genetic	27708008
COQ2_YEAST	COQ2	genetic	27708008
NUP60_YEAST	NUP60	genetic	27708008
RL19A_YEAST	RPL19B	genetic	27708008
RL19B_YEAST	RPL19B	genetic	27708008
PIN4_YEAST	PIN4	genetic	27708008
AST1_YEAST	AST1	genetic	27708008
ADPP_YEAST	YSA1	genetic	27708008
KTR4_YEAST	KTR4	genetic	27708008
PYC2_YEAST	PYC2	genetic	27708008
MRC1_YEAST	MRC1	genetic	27708008
SRF1_YEAST	SRF1	genetic	27708008
BLM10_YEAST	BLM10	genetic	27708008
CUL3_YEAST	CUL3	genetic	27708008
FKS2_YEAST	GSC2	genetic	27708008
PHB2_YEAST	PHB2	genetic	27708008
YOR1_YEAST	YOR1	genetic	27708008
ARP1_YEAST	ARP1	genetic	27708008
SIM1_YEAST	SIM1	genetic	27708008
ALLC_YEAST	DAL2	genetic	27708008
YJQ3_YEAST	YJL163C	genetic	27708008
MRT4_YEAST	MRT4	genetic	27708008
DCOR_YEAST	SPE1	genetic	27708008
CBT1_YEAST	CBT1	genetic	27708008
ALY1_YEAST	ALY1	genetic	27708008
YL173_YEAST	YLR173W	genetic	27708008
ROM2_YEAST	ROM2	genetic	27708008
PSP2_YEAST	PSP2	genetic	27708008
CACP_YEAST	CAT2	genetic	27708008
YMP8_YEAST	YMR018W	genetic	27708008
PEX12_YEAST	PEX12	genetic	27708008
RIM13_YEAST	RIM13	genetic	27708008
YM79_YEAST	YMR244W	genetic	27708008
HOR7_YEAST	HOR7	genetic	27708008
DSK2_YEAST	DSK2	genetic	27708008
LKHA4_YEAST	LAP2	genetic	27708008
CISY1_YEAST	CIT1	genetic	27708008
TOP1_YEAST	TOP1	genetic	27708008
HRD1_YEAST	HRD1	genetic	27708008
TAT2_YEAST	TAT2	genetic	27708008
PMG3_YEAST	GPM3	genetic	27708008
RTC1_YEAST	RTC1	genetic	27708008
RSB1_YEAST	RSB1	genetic	27708008
ETT1_YEAST	ETT1	genetic	27708008
NTO1_YEAST	NTO1	genetic	27708008
THP3_YEAST	THP3	genetic	27708008
MDM36_YEAST	MDM36	genetic	27708008
THI22_YEAST	THI22	genetic	27708008
PHSG_YEAST	GPH1	genetic	27708008
MET16_YEAST	MET16	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.