CACP_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CACP_YEAST
• UniProt AC: P32796
• Protein Name: Carnitine O-acetyltransferase, mitochondrial
• Gene Name: CAT2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 670
• Subcellular Localization: Isoform Mitochondrial: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.; Isoform Peroxisomal: Peroxisome.
• Protein Description: Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria..
• Protein Sequence: MRICHSRTLSNLKDLPITSRRAMHSAIVNYSTQKAQFPVETNNGEHYWAEKPNKFYQNKRPNFQGITFAKQQDLPSLPVPELKSTLDKYLQTIRPFCNDVETFERQQLLCKDFSEHMGPILQDRLKEYANDKRNWMAKFWDEQSYLQYNDPIVPYVSYFYSHMPLPNHLSKIDNDPLIKATAIISTVVKFIEAIKDESLPVEIIKGMPFCMNSFSLMFNTSRLPGKPEDNQDTNIFYSVYENNFVTIAYKGKFYKLMTHDGNDKPLSENEIWRQLYSVVFQGSQSDPKLGGIGSLTSLPRDQWREVHLELMKDPISQDSLETIHKSSFMLCLDLDQSPVTLEEKSRNCWHGDGINRFYDKSLQFLVTGNGSSGFLAEHSKMDGTPTLFLNNYVCQQLNKLDVDDFMRKVITPSSTVAMKPMELPFIITPKIHKAIESAQLQFKETIGEHDLRVWHYNKYGKTFIKRHGMSPDAFIQQVIQLAVFKYLKRQLPTYEAASTRKYFKGRTETGRSVSTASLEFVSKWQNGDVPIAEKIQALKHSAKEHSTYLKNAANGNGVDRHFFGLKNMLKSNDDQIPPLFKDPLFNYSSTWLISTSQLSSEYFDGYGWSQVNDNGFGLAYMLNNEWLHINIVNKPAKSGASVNRLHYYLSQAADEIFDALENENKRKAKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	TSRRAMHSAIVNYST CCHHHHHHHHHCCCC	13.45	27017623
30	Phosphorylation	MHSAIVNYSTQKAQF HHHHHHCCCCCEEEC	11.38	27017623
31	Phosphorylation	HSAIVNYSTQKAQFP HHHHHCCCCCEEECC	21.11	27017623
32	Phosphorylation	SAIVNYSTQKAQFPV HHHHCCCCCEEECCE	24.59	27017623
41	Phosphorylation	KAQFPVETNNGEHYW EEECCEECCCCCEEE	33.93	27017623
83	Ubiquitination	SLPVPELKSTLDKYL CCCHHHHHHHHHHHH	39.47	17644757
88	Ubiquitination	ELKSTLDKYLQTIRP HHHHHHHHHHHHHHH	51.47	17644757
89	Phosphorylation	LKSTLDKYLQTIRPF HHHHHHHHHHHHHHH	12.05	27017623
92	Phosphorylation	TLDKYLQTIRPFCND HHHHHHHHHHHHCCC	19.16	27017623
102	Phosphorylation	PFCNDVETFERQQLL HHCCCHHHHHHHHHH	30.55	27017623
296	Phosphorylation	LGGIGSLTSLPRDQW CCCCCCCCCCCHHHH	29.89	27214570
411	Phosphorylation	DFMRKVITPSSTVAM HHHHHHCCCCCCCCC	21.80	27017623
414	Phosphorylation	RKVITPSSTVAMKPM HHHCCCCCCCCCCCC	28.27	27017623
428	Phosphorylation	MELPFIITPKIHKAI CCCCEEECHHHHHHH	17.45	27017623
512	Phosphorylation	GRTETGRSVSTASLE CCCCCCCCEECHHHH	23.05	22369663
514	Phosphorylation	TETGRSVSTASLEFV CCCCCCEECHHHHHH	21.36	22369663
515	Phosphorylation	ETGRSVSTASLEFVS CCCCCEECHHHHHHH	20.36	22369663
517	Phosphorylation	GRSVSTASLEFVSKW CCCEECHHHHHHHHC	28.64	22369663
522	Phosphorylation	TASLEFVSKWQNGDV CHHHHHHHHCCCCCC	33.23	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CACP_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CACP_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CACP_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CACP_YEAST	CAT2	physical	11283351
PEX5_YEAST	PEX5	physical	18719252
CACP_YEAST	CAT2	physical	18719252
ODPA_YEAST	PDA1	genetic	16941010
CPT2_HUMAN	CPT2	genetic	20538056
APC11_YEAST	APC11	genetic	27708008
ERF3_YEAST	SUP35	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
DPOA_YEAST	POL1	genetic	27708008
NAB3_YEAST	NAB3	genetic	27708008
SDCB2_HUMAN	SDCBP2	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.