| UniProt ID | SRF1_YEAST | |
|---|---|---|
| UniProt AC | Q12516 | |
| Protein Name | Regulator of phospholipase D SRF1 | |
| Gene Name | SRF1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 437 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Regulator of phospholipase D (SPO14) which is required for SPO14 catalytic activity in mitotic cells. Essential to buffer the toxic effects of C16:0 platelet activating factor.. | |
| Protein Sequence | MGDSNSSQEAYSDTTSTNASRIADQNQLNLNVDLEKNQTVRKSGSLEALQNAKIHVPKHSDGSPLDYPKLNTYTFVPTTVPPYVLEAQFDKLRLQDKGTVDGNVTDDKNLPKEFKWGQFASTIGCHSAYTRDQNYNPSHKSYDGYSLSSSTSSKNAALREILGDMCSEWGGEERLEGVLHSEIGANLEFNTTEERKEWLQYIEKVKDFYYGDNKKNPESPESVHNKVYKSDWVNELNKEREKWRRLKQRKLQQWRPPLTSLLLDNQYLILGLRIFTGILSCISLALAIKIFQNSRSNNTISESKIGQQPSTIMAICVNAVAIAYIIYIAHDEFAGKPVGLRNPLSKLKLILLDLLFIIFSSANLALAFNTRFDKEWVCTSIRRSNGSTYGYPKIPRICRKQEALSAFLFVALFMWVITFSISIVRVVEKVSSITNRN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Ubiquitination | NLNVDLEKNQTVRKS CCCEECCCCCCHHCC | 23749301 | ||
| 39 | Phosphorylation | VDLEKNQTVRKSGSL EECCCCCCHHCCCCH | 19823750 | ||
| 42 | Ubiquitination | EKNQTVRKSGSLEAL CCCCCHHCCCCHHHH | 23749301 | ||
| 43 | Phosphorylation | KNQTVRKSGSLEALQ CCCCHHCCCCHHHHH | 22369663 | ||
| 45 | Phosphorylation | QTVRKSGSLEALQNA CCHHCCCCHHHHHCC | 22369663 | ||
| 60 | Phosphorylation | KIHVPKHSDGSPLDY EECCCCCCCCCCCCC | 21551504 | ||
| 63 | Phosphorylation | VPKHSDGSPLDYPKL CCCCCCCCCCCCCCC | 21440633 | ||
| 72 | Phosphorylation | LDYPKLNTYTFVPTT CCCCCCCCEEECCCC | 27017623 | ||
| 73 | Phosphorylation | DYPKLNTYTFVPTTV CCCCCCCEEECCCCC | 27017623 | ||
| 74 | Phosphorylation | YPKLNTYTFVPTTVP CCCCCCEEECCCCCC | 27017623 | ||
| 78 | Phosphorylation | NTYTFVPTTVPPYVL CCEEECCCCCCCCHH | 27017623 | ||
| 79 | Phosphorylation | TYTFVPTTVPPYVLE CEEECCCCCCCCHHE | 27017623 | ||
| 97 | Ubiquitination | DKLRLQDKGTVDGNV CEEECCCCCCCCCCC | 23749301 | ||
| 108 | Ubiquitination | DGNVTDDKNLPKEFK CCCCCCCCCCCCCCC | 23749301 | ||
| 122 | Phosphorylation | KWGQFASTIGCHSAY CCHHHHHHCCCCCCC | 28889911 | ||
| 127 | Phosphorylation | ASTIGCHSAYTRDQN HHHCCCCCCCCCCCC | 28889911 | ||
| 135 | Phosphorylation | AYTRDQNYNPSHKSY CCCCCCCCCCCCCCC | 28889911 | ||
| 138 | Phosphorylation | RDQNYNPSHKSYDGY CCCCCCCCCCCCCCC | 20377248 | ||
| 146 | Phosphorylation | HKSYDGYSLSSSTSS CCCCCCCCCCCCCCH | 30377154 | ||
| 149 | Phosphorylation | YDGYSLSSSTSSKNA CCCCCCCCCCCHHHH | 21551504 | ||
| 150 | Phosphorylation | DGYSLSSSTSSKNAA CCCCCCCCCCHHHHH | 21551504 | ||
| 152 | Phosphorylation | YSLSSSTSSKNAALR CCCCCCCCHHHHHHH | 27214570 | ||
| 153 | Phosphorylation | SLSSSTSSKNAALRE CCCCCCCHHHHHHHH | 27214570 | ||
| 154 | Ubiquitination | LSSSTSSKNAALREI CCCCCCHHHHHHHHH | 23749301 | ||
| 167 | Phosphorylation | EILGDMCSEWGGEER HHHHHHHHHCCCHHH | 21082442 | ||
| 206 | Acetylation | LQYIEKVKDFYYGDN HHHHHHHHHHHCCCC | 23572591 | ||
| 214 | Acetylation | DFYYGDNKKNPESPE HHHCCCCCCCCCCCH | 23572591 | ||
| 219 | Phosphorylation | DNKKNPESPESVHNK CCCCCCCCCHHHHHH | 25704821 | ||
| 222 | Phosphorylation | KNPESPESVHNKVYK CCCCCCHHHHHHHHH | 21551504 | ||
| 228 | Phosphorylation | ESVHNKVYKSDWVNE HHHHHHHHHHHHHHH | 21126336 | ||
| 276 | Phosphorylation | ILGLRIFTGILSCIS HHHHHHHHHHHHHHH | 27017623 | ||
| 280 | Phosphorylation | RIFTGILSCISLALA HHHHHHHHHHHHHHH | 27017623 | ||
| 283 | Phosphorylation | TGILSCISLALAIKI HHHHHHHHHHHHHHH | 27017623 | ||
| 297 | N-linked_Glycosylation | IFQNSRSNNTISESK HHHCCCCCCCCCHHH | - | ||
| 385 | N-linked_Glycosylation | CTSIRRSNGSTYGYP EEEEECCCCCCCCCC | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SRF1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SRF1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SRF1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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