DDR48_YEAST - dbPTM
DDR48_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DDR48_YEAST
UniProt AC P18899
Protein Name Stress protein DDR48
Gene Name DDR48
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 430
Subcellular Localization
Protein Description DNA damage-responsive protein that may be required for maintaining the rate of spontaneous mutagenesis. Shows low ATP and GTP hydrolysis activity. Dispensable for acquisition of thermotolerance and does not play a significant role in recovery or protection of cells from acute heat shock..
Protein Sequence MGLFDKVKQFANSNNNNNDSGNNNQGDYVTKAENMIGEDRVNQFKSKIGEDRFDKMESKVRQQFSNTSINDNDSNNNDSYGSNNNDSYGSNNNDSYGSNNNDSYGSNNNDSYGSNNDDSYGSSNKKKSSYGSNNDDSYGSSNNNDSYGSNNNDSYGSNNNDSYGSNNDDSYGSSNKNKSSYGSNNDDSYGSNNDDSYGSSNKKKSSYGSSNNDSYGSNNDDSYGSNNNDSYGSNNDDSYGSSNKKKSSYGSNNDDSYGSSNNNDSYGSNNDDSYGSSNKNKSSYGSSSNDDSYGSSNNDDSYGSSNKKKSSYGSNNDDSYGSNNDDSYGSSNKKKSSYGSSNNDSYGSNNDDSYGSSNKKKSSYGSNNDDSYGSSNNNDSYGSNNDDSYGSSNRNKNSYGSSNYGSSNNDDSYGSSNRGGRNQYGGDDDY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Ubiquitination--MGLFDKVKQFANS
--CCHHHHHHHHHCC		43.9522817900
8UbiquitinationMGLFDKVKQFANSNN
CCHHHHHHHHHCCCC		45.5023749301
13PhosphorylationKVKQFANSNNNNNDS
HHHHHHCCCCCCCCC		37.1922369663
20PhosphorylationSNNNNNDSGNNNQGD
CCCCCCCCCCCCCHH		45.6122369663
28PhosphorylationGNNNQGDYVTKAENM
CCCCCHHHHHHHHHH		19.4922369663
30PhosphorylationNNQGDYVTKAENMIG
CCCHHHHHHHHHHHC		20.5022369663
31AcetylationNQGDYVTKAENMIGE
CCHHHHHHHHHHHCH		43.5924489116
452-HydroxyisobutyrylationEDRVNQFKSKIGEDR
HHHHHHHHHHHCHHH		40.87-
45AcetylationEDRVNQFKSKIGEDR
HHHHHHHHHHHCHHH		40.8724489116
46PhosphorylationDRVNQFKSKIGEDRF
HHHHHHHHHHCHHHH		30.6921440633
55AcetylationIGEDRFDKMESKVRQ
HCHHHHHHHHHHHHH		41.6824489116
111PhosphorylationYGSNNNDSYGSNNDD
CCCCCCCCCCCCCCC		33.2528889911
112PhosphorylationGSNNNDSYGSNNDDS
CCCCCCCCCCCCCCC		27.6921082442
114PhosphorylationNNNDSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9922369663
119PhosphorylationYGSNNDDSYGSSNKK
CCCCCCCCCCCCCCC		33.9722369663
120PhosphorylationGSNNDDSYGSSNKKK
CCCCCCCCCCCCCCC		28.2028889911
122PhosphorylationNNDDSYGSSNKKKSS
CCCCCCCCCCCCCCC		23.6222369663
123PhosphorylationNDDSYGSSNKKKSSY
CCCCCCCCCCCCCCC		48.5922369663
128PhosphorylationGSSNKKKSSYGSNND
CCCCCCCCCCCCCCC		37.3620377248
129PhosphorylationSSNKKKSSYGSNNDD
CCCCCCCCCCCCCCC		42.2520377248
130PhosphorylationSNKKKSSYGSNNDDS
CCCCCCCCCCCCCCC		31.5022369663
132PhosphorylationKKKSSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9920377248
137PhosphorylationYGSNNDDSYGSSNNN
CCCCCCCCCCCCCCC		33.9720377248
138PhosphorylationGSNNDDSYGSSNNND
CCCCCCCCCCCCCCC		28.2022369663
140PhosphorylationNNDDSYGSSNNNDSY
CCCCCCCCCCCCCCC		22.9720377248
141PhosphorylationNDDSYGSSNNNDSYG
CCCCCCCCCCCCCCC		38.9322369663
162PhosphorylationYGSNNNDSYGSNNDD
CCCCCCCCCCCCCCC		33.2528889911
163PhosphorylationGSNNNDSYGSNNDDS
CCCCCCCCCCCCCCC		27.6921082442
165PhosphorylationNNNDSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9922369663
170PhosphorylationYGSNNDDSYGSSNKN
CCCCCCCCCCCCCCC		33.9720377248
176UbiquitinationDSYGSSNKNKSSYGS
CCCCCCCCCCCCCCC		68.6417644757
178UbiquitinationYGSSNKNKSSYGSNN
CCCCCCCCCCCCCCC		42.2523749301
179PhosphorylationGSSNKNKSSYGSNND
CCCCCCCCCCCCCCC		37.8822369663
180PhosphorylationSSNKNKSSYGSNNDD
CCCCCCCCCCCCCCC		34.8120377248
181PhosphorylationSNKNKSSYGSNNDDS
CCCCCCCCCCCCCCC		31.5020377248
183PhosphorylationKNKSSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9922369663
188PhosphorylationYGSNNDDSYGSNNDD
CCCCCCCCCCCCCCC		33.9722369663
189PhosphorylationGSNNDDSYGSNNDDS
CCCCCCCCCCCCCCC		31.4120377248
191PhosphorylationNNDDSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9922369663
196PhosphorylationYGSNNDDSYGSSNKK
CCCCCCCCCCCCCCC		33.9722369663
197PhosphorylationGSNNDDSYGSSNKKK
CCCCCCCCCCCCCCC		28.2022369663
199PhosphorylationNNDDSYGSSNKKKSS
CCCCCCCCCCCCCCC		23.6220377248
200PhosphorylationNDDSYGSSNKKKSSY
CCCCCCCCCCCCCCC		48.5922369663
202UbiquitinationDSYGSSNKKKSSYGS
CCCCCCCCCCCCCCC		64.6222106047
203UbiquitinationSYGSSNKKKSSYGSS
CCCCCCCCCCCCCCC		63.2417644757
205PhosphorylationGSSNKKKSSYGSSNN
CCCCCCCCCCCCCCC		37.3622369663
206PhosphorylationSSNKKKSSYGSSNND
CCCCCCCCCCCCCCC		42.2522369663
207PhosphorylationSNKKKSSYGSSNNDS
CCCCCCCCCCCCCCC		28.2819779198
209PhosphorylationKKKSSYGSSNNDSYG
CCCCCCCCCCCCCCC		22.9722369663
210PhosphorylationKKSSYGSSNNDSYGS
CCCCCCCCCCCCCCC		34.9820377248
214PhosphorylationYGSSNNDSYGSNNDD
CCCCCCCCCCCCCCC		33.2522369663
215PhosphorylationGSSNNDSYGSNNDDS
CCCCCCCCCCCCCCC		27.6922369663
217PhosphorylationSNNDSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9919779198
223PhosphorylationGSNNDDSYGSNNNDS
CCCCCCCCCCCCCCC		31.4123749301
225PhosphorylationNNDDSYGSNNNDSYG
CCCCCCCCCCCCCCC		28.3121440633
230PhosphorylationYGSNNNDSYGSNNDD
CCCCCCCCCCCCCCC		33.2520377248
231PhosphorylationGSNNNDSYGSNNDDS
CCCCCCCCCCCCCCC		27.6921082442
233PhosphorylationNNNDSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9920377248
238PhosphorylationYGSNNDDSYGSSNKK
CCCCCCCCCCCCCCC		33.9717563356
239PhosphorylationGSNNDDSYGSSNKKK
CCCCCCCCCCCCCCC		28.2028889911
241PhosphorylationNNDDSYGSSNKKKSS
CCCCCCCCCCCCCCC		23.6222369663
242PhosphorylationNDDSYGSSNKKKSSY
CCCCCCCCCCCCCCC		48.5922369663
247PhosphorylationGSSNKKKSSYGSNND
CCCCCCCCCCCCCCC		37.3620377248
248PhosphorylationSSNKKKSSYGSNNDD
CCCCCCCCCCCCCCC		42.2522369663
249PhosphorylationSNKKKSSYGSNNDDS
CCCCCCCCCCCCCCC		31.5022369663
251PhosphorylationKKKSSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9922369663
256PhosphorylationYGSNNDDSYGSSNNN
CCCCCCCCCCCCCCC		33.9720377248
257PhosphorylationGSNNDDSYGSSNNND
CCCCCCCCCCCCCCC		28.2020377248
259PhosphorylationNNDDSYGSSNNNDSY
CCCCCCCCCCCCCCC		22.9720377248
260PhosphorylationNDDSYGSSNNNDSYG
CCCCCCCCCCCCCCC		38.9320377248
265PhosphorylationGSSNNNDSYGSNNDD
CCCCCCCCCCCCCCC		33.2522369663
266PhosphorylationSSNNNDSYGSNNDDS
CCCCCCCCCCCCCCC		27.6922369663
268PhosphorylationNNNDSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9920377248
273PhosphorylationYGSNNDDSYGSSNKN
CCCCCCCCCCCCCCC		33.9720377248
274PhosphorylationGSNNDDSYGSSNKNK
CCCCCCCCCCCCCCC		28.2022369663
276PhosphorylationNNDDSYGSSNKNKSS
CCCCCCCCCCCCCCC		23.6223749301
277PhosphorylationNDDSYGSSNKNKSSY
CCCCCCCCCCCCCCC		47.6722369663
282PhosphorylationGSSNKNKSSYGSSSN
CCCCCCCCCCCCCCC		37.8822369663
283PhosphorylationSSNKNKSSYGSSSND
CCCCCCCCCCCCCCC		34.8120377248
284PhosphorylationSNKNKSSYGSSSNDD
CCCCCCCCCCCCCCC		28.2820377248
286PhosphorylationKNKSSYGSSSNDDSY
CCCCCCCCCCCCCCC		23.5120377248
287PhosphorylationNKSSYGSSSNDDSYG
CCCCCCCCCCCCCCC		28.8822369663
288PhosphorylationKSSYGSSSNDDSYGS
CCCCCCCCCCCCCCC		46.0722369663
292PhosphorylationGSSSNDDSYGSSNND
CCCCCCCCCCCCCCC		33.9720377248
293PhosphorylationSSSNDDSYGSSNNDD
CCCCCCCCCCCCCCC		28.2020377248
295PhosphorylationSNDDSYGSSNNDDSY
CCCCCCCCCCCCCCC		22.9722369663
296PhosphorylationNDDSYGSSNNDDSYG
CCCCCCCCCCCCCCC		34.9822369663
301PhosphorylationGSSNNDDSYGSSNKK
CCCCCCCCCCCCCCC		33.9722369663
302PhosphorylationSSNNDDSYGSSNKKK
CCCCCCCCCCCCCCC		28.2020377248
304PhosphorylationNNDDSYGSSNKKKSS
CCCCCCCCCCCCCCC		23.6222369663
305PhosphorylationNDDSYGSSNKKKSSY
CCCCCCCCCCCCCCC		48.5922369663
309UbiquitinationYGSSNKKKSSYGSNN
CCCCCCCCCCCCCCC		46.3617644757
310PhosphorylationGSSNKKKSSYGSNND
CCCCCCCCCCCCCCC		37.3622369663
311PhosphorylationSSNKKKSSYGSNNDD
CCCCCCCCCCCCCCC		42.2520377248
312PhosphorylationSNKKKSSYGSNNDDS
CCCCCCCCCCCCCCC		31.5020377248
314PhosphorylationKKKSSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9922369663
319PhosphorylationYGSNNDDSYGSNNDD
CCCCCCCCCCCCCCC		33.9722369663
320PhosphorylationGSNNDDSYGSNNDDS
CCCCCCCCCCCCCCC		31.4120377248
322PhosphorylationNNDDSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9922369663
327PhosphorylationYGSNNDDSYGSSNKK
CCCCCCCCCCCCCCC		33.9722369663
328PhosphorylationGSNNDDSYGSSNKKK
CCCCCCCCCCCCCCC		28.2022369663
330PhosphorylationNNDDSYGSSNKKKSS
CCCCCCCCCCCCCCC		23.6222369663
331PhosphorylationNDDSYGSSNKKKSSY
CCCCCCCCCCCCCCC		48.5922369663
333UbiquitinationDSYGSSNKKKSSYGS
CCCCCCCCCCCCCCC		64.6222106047
334UbiquitinationSYGSSNKKKSSYGSS
CCCCCCCCCCCCCCC		63.2417644757
335UbiquitinationYGSSNKKKSSYGSSN
CCCCCCCCCCCCCCC		46.3615699485
336PhosphorylationGSSNKKKSSYGSSNN
CCCCCCCCCCCCCCC		37.3620377248
337PhosphorylationSSNKKKSSYGSSNND
CCCCCCCCCCCCCCC		42.2520377248
338PhosphorylationSNKKKSSYGSSNNDS
CCCCCCCCCCCCCCC		28.2822369663
340PhosphorylationKKKSSYGSSNNDSYG
CCCCCCCCCCCCCCC		22.9720377248
341PhosphorylationKKSSYGSSNNDSYGS
CCCCCCCCCCCCCCC		34.9820377248
345PhosphorylationYGSSNNDSYGSNNDD
CCCCCCCCCCCCCCC		33.2520377248
346PhosphorylationGSSNNDSYGSNNDDS
CCCCCCCCCCCCCCC		27.6920377248
348PhosphorylationSNNDSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9920377248
353PhosphorylationYGSNNDDSYGSSNKK
CCCCCCCCCCCCCCC		33.9722369663
354PhosphorylationGSNNDDSYGSSNKKK
CCCCCCCCCCCCCCC		28.2022369663
356PhosphorylationNNDDSYGSSNKKKSS
CCCCCCCCCCCCCCC		23.6222369663
357PhosphorylationNDDSYGSSNKKKSSY
CCCCCCCCCCCCCCC		48.5922369663
359UbiquitinationDSYGSSNKKKSSYGS
CCCCCCCCCCCCCCC		64.6215699485
360UbiquitinationSYGSSNKKKSSYGSN
CCCCCCCCCCCCCCC		63.2415699485
362PhosphorylationGSSNKKKSSYGSNND
CCCCCCCCCCCCCCC		37.3622369663
363PhosphorylationSSNKKKSSYGSNNDD
CCCCCCCCCCCCCCC		42.2520377248
364PhosphorylationSNKKKSSYGSNNDDS
CCCCCCCCCCCCCCC		31.5022369663
366PhosphorylationKKKSSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9920377248
371PhosphorylationYGSNNDDSYGSSNNN
CCCCCCCCCCCCCCC		33.9720377248
372PhosphorylationGSNNDDSYGSSNNND
CCCCCCCCCCCCCCC		28.2020377248
374PhosphorylationNNDDSYGSSNNNDSY
CCCCCCCCCCCCCCC		22.9720377248
375PhosphorylationNDDSYGSSNNNDSYG
CCCCCCCCCCCCCCC		38.9320377248
380PhosphorylationGSSNNNDSYGSNNDD
CCCCCCCCCCCCCCC		33.2520377248
381PhosphorylationSSNNNDSYGSNNDDS
CCCCCCCCCCCCCCC		27.6920377248
383PhosphorylationNNNDSYGSNNDDSYG
CCCCCCCCCCCCCCC		24.9920377248
388PhosphorylationYGSNNDDSYGSSNRN
CCCCCCCCCCCCCCC		33.9722369663
389PhosphorylationGSNNDDSYGSSNRNK
CCCCCCCCCCCCCCC		28.2022369663
391PhosphorylationNNDDSYGSSNRNKNS
CCCCCCCCCCCCCCC		19.0622369663
392PhosphorylationNDDSYGSSNRNKNSY
CCCCCCCCCCCCCCC		35.1322369663
396UbiquitinationYGSSNRNKNSYGSSN
CCCCCCCCCCCCCCC		43.9922817900
398PhosphorylationSSNRNKNSYGSSNYG
CCCCCCCCCCCCCCC		32.2622369663
399PhosphorylationSNRNKNSYGSSNYGS
CCCCCCCCCCCCCCC		30.3522369663
401PhosphorylationRNKNSYGSSNYGSSN
CCCCCCCCCCCCCCC		13.7422369663
402PhosphorylationNKNSYGSSNYGSSNN
CCCCCCCCCCCCCCC		29.7022369663
404PhosphorylationNSYGSSNYGSSNNDD
CCCCCCCCCCCCCCC		21.9722369663
406PhosphorylationYGSSNYGSSNNDDSY
CCCCCCCCCCCCCCC		21.3822369663
407PhosphorylationGSSNYGSSNNDDSYG
CCCCCCCCCCCCCCC		34.9822369663
412PhosphorylationGSSNNDDSYGSSNRG
CCCCCCCCCCCCCCC		33.9722369663
413PhosphorylationSSNNDDSYGSSNRGG
CCCCCCCCCCCCCCC		28.2022369663
415PhosphorylationNNDDSYGSSNRGGRN
CCCCCCCCCCCCCCC		19.0622369663
416PhosphorylationNDDSYGSSNRGGRNQ
CCCCCCCCCCCCCCC		26.6122369663
424PhosphorylationNRGGRNQYGGDDDY-
CCCCCCCCCCCCCC-		26.9919823750
430PhosphorylationQYGGDDDY-------
CCCCCCCC-------		27.7019823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DDR48_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DDR48_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DDR48_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ATPD_YEASTATP16physical
16554755
IDHP_YEASTIDP1physical
16554755
SEM1_YEASTSEM1physical
16554755
MLC1_YEASTMLC1physical
16554755
STM1_YEASTSTM1physical
16554755
USA1_YEASTUSA1physical
16554755
SHH3_YEASTSHH3physical
16554755
FCP1_YEASTFCP1physical
16554755
ZEO1_YEASTZEO1physical
16554755
UTP17_YEASTNAN1physical
16554755
CIN4_YEASTCIN4genetic
17314980
RAD24_YEASTRAD24genetic
17314980
SODC_YEASTSOD1genetic
17314980
UBC13_YEASTUBC13genetic
17314980
BRE2_YEASTBRE2genetic
17314980
CG13_YEASTCLN3genetic
17314980
TSA1_YEASTTSA1genetic
17314980
DMC1_YEASTDMC1genetic
17314980
DOT1_YEASTDOT1genetic
17314980
GPR1_YEASTGPR1genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
ELO2_YEASTELO2genetic
27708008
THRC_YEASTTHR4genetic
27708008
BCK1_YEASTBCK1genetic
27708008
ORM2_YEASTORM2genetic
27708008
YL413_YEASTINA1genetic
27708008
SUCA_YEASTLSC1genetic
27708008
WDR6_YEASTRTT10genetic
27708008
FUMH_YEASTFUM1genetic
27708008
DBF4_YEASTDBF4genetic
29674565
BTN1_YEASTYHC3genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DDR48_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-181; SER-183; SER-288;SER-295; SER-319; SER-322; SER-353 AND SER-383, AND MASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319; SER-322; SER-327AND SER-330, AND MASS SPECTROMETRY.

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