IDHP_YEAST - dbPTM
IDHP_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IDHP_YEAST
UniProt AC P21954
Protein Name Isocitrate dehydrogenase [NADP], mitochondrial
Gene Name IDP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 428
Subcellular Localization Mitochondrion.
Protein Description Mitochondrial IDP1 may regulate flux through the tricarboxylic acid cycle and respiration. Its probably critical function is the production of NADPH..
Protein Sequence MSMLSRRLFSTSRLAAFSKIKVKQPVVELDGDEMTRIIWDKIKKKLILPYLDVDLKYYDLSVESRDATSDKITQDAAEAIKKYGVGIKCATITPDEARVKEFNLHKMWKSPNGTIRNILGGTVFREPIVIPRIPRLVPRWEKPIIIGRHAHGDQYKATDTLIPGPGSLELVYKPSDPTTAQPQTLKVYDYKGSGVAMAMYNTDESIEGFAHSSFKLAIDKKLNLFLSTKNTILKKYDGRFKDIFQEVYEAQYKSKFEQLGIHYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILVTPDGKTFESEAAHGTVTRHYRKYQKGEETSTNSIASIFAWSRGLLKRGELDNTPALCKFANILESATLNTVQQDGIMTKDLALACGNNERSAYVTTEEFLDAVEKRLQKEIKSIE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
11PhosphorylationLSRRLFSTSRLAAFS
HHHHHHCHHHHHHHH		15.5527017623
18PhosphorylationTSRLAAFSKIKVKQP
HHHHHHHHCCEECCC		28.8327017623
41AcetylationMTRIIWDKIKKKLIL
HHHHHHHHHHHHHEE		41.2424489116
69PhosphorylationVESRDATSDKITQDA
CCCCCCCCCCCCHHH		38.3328889911
71AcetylationSRDATSDKITQDAAE
CCCCCCCCCCHHHHH		47.6324489116
81SuccinylationQDAAEAIKKYGVGIK
HHHHHHHHHHCCCCE		47.1723954790
81AcetylationQDAAEAIKKYGVGIK
HHHHHHHHHHCCCCE		47.1724489116
82AcetylationDAAEAIKKYGVGIKC
HHHHHHHHHCCCCEE		40.9225381059
93PhosphorylationGIKCATITPDEARVK
CCEEEEECCCHHHHH		21.9727214570
100AcetylationTPDEARVKEFNLHKM
CCCHHHHHHCCHHHH		51.5422865919
106AcetylationVKEFNLHKMWKSPNG
HHHCCHHHHCCCCCC		50.0124489116
109SuccinylationFNLHKMWKSPNGTIR
CCHHHHCCCCCCCCC		53.1623954790
109AcetylationFNLHKMWKSPNGTIR
CCHHHHCCCCCCCCC		53.1624489116
142AcetylationRLVPRWEKPIIIGRH
CCCCCCCCCEEEECC		34.2624489116
142UbiquitinationRLVPRWEKPIIIGRH
CCCCCCCCCEEEECC		34.2624961812
156AcetylationHAHGDQYKATDTLIP
CCCCCCCCCCCEEEC		38.8924489116
156UbiquitinationHAHGDQYKATDTLIP
CCCCCCCCCCCEEEC		38.8919722269
173UbiquitinationGSLELVYKPSDPTTA
CEEEEEECCCCCCCC		30.4819722269
173SuccinylationGSLELVYKPSDPTTA
CEEEEEECCCCCCCC		30.4823954790
173AcetylationGSLELVYKPSDPTTA
CEEEEEECCCCCCCC		30.4824489116
186AcetylationTAQPQTLKVYDYKGS
CCCCCEEEEEEECCC		41.9824489116
227PhosphorylationKKLNLFLSTKNTILK
HHHCEEEECCCCHHH		29.9630377154
241AcetylationKKYDGRFKDIFQEVY
HHCCCCHHHHHHHHH		48.8624489116
253AcetylationEVYEAQYKSKFEQLG
HHHHHHHHHHHHHCC		34.7824489116
255AcetylationYEAQYKSKFEQLGIH
HHHHHHHHHHHCCCC		49.0924489116
279AcetylationVAQMIKSKGGFIMAL
HHHHHHCCCCEEEEE		59.0422865919
336PhosphorylationVTRHYRKYQKGEETS
HHHHHHHHCCCCCCC		13.3727017623
338AcetylationRHYRKYQKGEETSTN
HHHHHHCCCCCCCCH		66.2624489116
342PhosphorylationKYQKGEETSTNSIAS
HHCCCCCCCCHHHHH		36.2327017623
343PhosphorylationYQKGEETSTNSIASI
HCCCCCCCCHHHHHH		28.9527017623
392AcetylationQQDGIMTKDLALACG
CCCCCCCHHHHHHCC		33.1125381059
418AcetylationEFLDAVEKRLQKEIK
HHHHHHHHHHHHHHH		52.3824489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IDHP_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IDHP_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IDHP_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BRE5_YEASTBRE5physical
16429126
KPYK1_YEASTCDC19physical
16429126
RAD50_YEASTRAD50physical
16429126
RS3A1_YEASTRPS1Aphysical
16429126
UBP3_YEASTUBP3physical
16429126
POS5_YEASTPOS5genetic
19158096
SEF1_YEASTSEF1genetic
20093466
MGR1_YEASTMGR1genetic
20093466
KIN82_YEASTKIN82genetic
20093466
SSD1_YEASTSSD1genetic
20093466
CBT1_YEASTCBT1genetic
20093466
RL40A_YEASTRPL40Bgenetic
20093466
RL40B_YEASTRPL40Bgenetic
20093466
UBP15_YEASTUBP15genetic
20093466
IDH1_YEASTIDH1genetic
20093466
IDH2_YEASTIDH2genetic
20093466
FUMH_YEASTFUM1genetic
20093466
ATG41_YEASTICY2genetic
20093466
IDH1_YEASTIDH1genetic
21623372
IDH2_YEASTIDH2genetic
21623372
THDH_YEASTILV1genetic
21623372
DCAM_YEASTSPE2genetic
21623372
KIN82_YEASTKIN82genetic
22282571
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IDHP_YEAST

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Related Literatures of Post-Translational Modification

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