dbPTM

MSC3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MSC3_YEAST
UniProt AC	Q05812
Protein Name	Meiotic sister-chromatid recombination protein 3
Gene Name	MSC3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	728
Subcellular Localization	Cell membrane Peripheral membrane protein . Cell periphery.
Protein Description	May be involved in the control of meiotic sister-chromatid recombination..
Protein Sequence	MVFGFTKRDRRVPDLSRYDYYYQNHEDYNKSPQLSAAAASAASAASPDRTNYSRSHSLVSHAPSIPRQRSSVKSPGRRLSTSSAAPPTSRAAAKQYSQKTYSLRSQRSGEYHLHPPGYTTNGSRMNSMTSGANVRRNYGKNKSTAGNNNDSRANSITVKTTQVTDPSGRTQSITKKTIRKINGYEYVETTTTTKNLVPLGDSQRHFDEFSENYMLQDDDILEEQASDNIHDIIEENETDNEKPYSPVSESHLQDDSELNVEKPDFPLGSYFHHKYSTDVMPLEEESSLSNFSDALDYIPPTHQTSSKYIHNKRKQASTTRRKKRPPAVKNAEAEAKKPLTEAEMYLKALEVAKRNVYHTDAASDNASAPLGSNKSRKSRMGQKMTLRSSSDSPTATANLVKSNVEVQPKRFTSSFFSRNTKSAPHEVHNHSVSTHFKSNKAVDPVPEPKSANTGLTDKEMYDQALKIAQARYYNSHGIQPEAVDNSTTAAKPRQVGVSHLGSTGSIPPNEQHYLGDSEIPVQSEVHEYEPIPLQKTKTTGSSKNKFKTMFDKVLQFSQENYGYQHKKEQGEQTPVTRNAEESFPAASISEGVTTAKPSSNEGVMTNPVVTDSPSPLQQQIDSTTASSNGQSQGNVPTSAVASTTRTRSPELQDNLKSSSSLLQDQTPQRQEDATDPTTSSTNELSAAEPTMVTSTHATKTIQAQTQDPPTKHKKSSFFTKLFKKKSSR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	NHEDYNKSPQLSAAA CCCHHCCCHHHHHHH	17.78	24909858
35	Phosphorylation	YNKSPQLSAAAASAA HCCCHHHHHHHHHHH	15.60	19779198
40	Phosphorylation	QLSAAAASAASAASP HHHHHHHHHHHHCCC	21.46	19779198
43	Phosphorylation	AAAASAASAASPDRT HHHHHHHHHCCCCCC	24.88	19779198
46	Phosphorylation	ASAASAASPDRTNYS HHHHHHCCCCCCCCC	27.35	28889911
50	Phosphorylation	SAASPDRTNYSRSHS HHCCCCCCCCCCCCC	45.98	23749301
52	Phosphorylation	ASPDRTNYSRSHSLV CCCCCCCCCCCCCHH	12.59	27017623
53	Phosphorylation	SPDRTNYSRSHSLVS CCCCCCCCCCCCHHH	29.40	23749301
55	Phosphorylation	DRTNYSRSHSLVSHA CCCCCCCCCCHHHCC	16.10	22369663
57	Phosphorylation	TNYSRSHSLVSHAPS CCCCCCCCHHHCCCC	31.54	22369663
60	Phosphorylation	SRSHSLVSHAPSIPR CCCCCHHHCCCCCCC	21.16	22369663
64	Phosphorylation	SLVSHAPSIPRQRSS CHHHCCCCCCCCCCC	46.11	22369663
74	Phosphorylation	RQRSSVKSPGRRLST CCCCCCCCCCCCCCC	30.36	19823750
80	Phosphorylation	KSPGRRLSTSSAAPP CCCCCCCCCCCCCCC	25.16	22369663
81	Phosphorylation	SPGRRLSTSSAAPPT CCCCCCCCCCCCCCC	31.15	22369663
82	Phosphorylation	PGRRLSTSSAAPPTS CCCCCCCCCCCCCCC	18.01	22369663
83	Phosphorylation	GRRLSTSSAAPPTSR CCCCCCCCCCCCCCH	28.65	22369663
88	Phosphorylation	TSSAAPPTSRAAAKQ CCCCCCCCCHHHHHH	29.77	22890988
89	Phosphorylation	SSAAPPTSRAAAKQY CCCCCCCCHHHHHHH	26.20	22890988
99	Acetylation	AAKQYSQKTYSLRSQ HHHHHCCCCCCCCCC	43.41	22865919
100	Phosphorylation	AKQYSQKTYSLRSQR HHHHCCCCCCCCCCC	15.65	22369663
101	Phosphorylation	KQYSQKTYSLRSQRS HHHCCCCCCCCCCCC	16.85	22369663
102	Phosphorylation	QYSQKTYSLRSQRSG HHCCCCCCCCCCCCC	23.65	22369663
105	Phosphorylation	QKTYSLRSQRSGEYH CCCCCCCCCCCCCCC	34.93	22369663
108	Phosphorylation	YSLRSQRSGEYHLHP CCCCCCCCCCCCCCC	28.48	22369663
111	Phosphorylation	RSQRSGEYHLHPPGY CCCCCCCCCCCCCCC	17.13	23749301
118	Phosphorylation	YHLHPPGYTTNGSRM CCCCCCCCCCCCCCC	19.03	22369663
119	Phosphorylation	HLHPPGYTTNGSRMN CCCCCCCCCCCCCCC	21.50	22369663
120	Phosphorylation	LHPPGYTTNGSRMNS CCCCCCCCCCCCCCC	29.15	22369663
123	Phosphorylation	PGYTTNGSRMNSMTS CCCCCCCCCCCCCCC	30.35	22369663
127	Phosphorylation	TNGSRMNSMTSGANV CCCCCCCCCCCCHHC	17.69	22369663
129	Phosphorylation	GSRMNSMTSGANVRR CCCCCCCCCCHHCHH	24.67	22369663
130	Phosphorylation	SRMNSMTSGANVRRN CCCCCCCCCHHCHHH	27.54	22369663
143	Phosphorylation	RNYGKNKSTAGNNND HHCCCCCCCCCCCCC	32.65	22890988
144	Phosphorylation	NYGKNKSTAGNNNDS HCCCCCCCCCCCCCH	39.95	22890988
151	Phosphorylation	TAGNNNDSRANSITV CCCCCCCHHCCEEEE	35.10	22369663
155	Phosphorylation	NNDSRANSITVKTTQ CCCHHCCEEEEEEEE	20.74	22369663
157	Phosphorylation	DSRANSITVKTTQVT CHHCCEEEEEEEEEE	18.77	22890988
159	Ubiquitination	RANSITVKTTQVTDP HCCEEEEEEEEEECC	36.89	23749301
161	Phosphorylation	NSITVKTTQVTDPSG CEEEEEEEEEECCCC	18.48	21440633
164	Phosphorylation	TVKTTQVTDPSGRTQ EEEEEEEECCCCCCE	32.16	21440633
167	Phosphorylation	TTQVTDPSGRTQSIT EEEEECCCCCCEEEE	43.66	22369663
170	Phosphorylation	VTDPSGRTQSITKKT EECCCCCCEEEEHHH	30.14	22369663
172	Phosphorylation	DPSGRTQSITKKTIR CCCCCCEEEEHHHHH	31.45	22369663
174	Phosphorylation	SGRTQSITKKTIRKI CCCCEEEEHHHHHHC	31.56	20377248
180	Ubiquitination	ITKKTIRKINGYEYV EEHHHHHHCCCEEEE	36.35	23749301
275	Phosphorylation	GSYFHHKYSTDVMPL HHHCCCCCCCCCCCC	16.67	21551504
286	Phosphorylation	VMPLEEESSLSNFSD CCCCCCCHHCCCHHH	39.60	20377248
287	Phosphorylation	MPLEEESSLSNFSDA CCCCCCHHCCCHHHH	38.81	21440633
289	Phosphorylation	LEEESSLSNFSDALD CCCCHHCCCHHHHHH	37.46	21440633
292	Phosphorylation	ESSLSNFSDALDYIP CHHCCCHHHHHHCCC	26.65	21440633
357	Phosphorylation	EVAKRNVYHTDAASD HHHHHHCCCCCCCCC	11.53	29136822
359	Phosphorylation	AKRNVYHTDAASDNA HHHHCCCCCCCCCCC	15.05	29136822
363	Phosphorylation	VYHTDAASDNASAPL CCCCCCCCCCCCCCC	32.87	22369663
367	Phosphorylation	DAASDNASAPLGSNK CCCCCCCCCCCCCCC	36.35	22369663
372	Phosphorylation	NASAPLGSNKSRKSR CCCCCCCCCCCHHCC	49.09	21440633
378	Phosphorylation	GSNKSRKSRMGQKMT CCCCCHHCCCCCCCE	26.79	28889911
385	Phosphorylation	SRMGQKMTLRSSSDS CCCCCCCEECCCCCC	26.51	22369663
388	Phosphorylation	GQKMTLRSSSDSPTA CCCCEECCCCCCCCH	36.99	22890988
389	Phosphorylation	QKMTLRSSSDSPTAT CCCEECCCCCCCCHH	31.56	25521595
390	Phosphorylation	KMTLRSSSDSPTATA CCEECCCCCCCCHHH	43.27	25521595
392	Phosphorylation	TLRSSSDSPTATANL EECCCCCCCCHHHHH	26.54	22369663
394	Phosphorylation	RSSSDSPTATANLVK CCCCCCCCHHHHHHH	40.36	22890988
396	Phosphorylation	SSDSPTATANLVKSN CCCCCCHHHHHHHCC	20.68	22890988
413	Phosphorylation	VQPKRFTSSFFSRNT ECCCCCCHHHHCCCC	23.57	30377154
414	Phosphorylation	QPKRFTSSFFSRNTK CCCCCCHHHHCCCCC	27.53	30377154
458	Ubiquitination	ANTGLTDKEMYDQAL CCCCCCCHHHHHHHH	38.86	23749301
466	Ubiquitination	EMYDQALKIAQARYY HHHHHHHHHHHHHHH	38.72	24961812
486	Phosphorylation	QPEAVDNSTTAAKPR CHHHCCCCCCCCCCC	23.75	19779198
487	Phosphorylation	PEAVDNSTTAAKPRQ HHHCCCCCCCCCCCE	27.06	19779198
491	Acetylation	DNSTTAAKPRQVGVS CCCCCCCCCCEECCC	37.96	24489116
491	Ubiquitination	DNSTTAAKPRQVGVS CCCCCCCCCCEECCC	37.96	23749301
503	Phosphorylation	GVSHLGSTGSIPPNE CCCCCCCCCCCCCCC	32.90	21551504
505	Phosphorylation	SHLGSTGSIPPNEQH CCCCCCCCCCCCCCC	31.82	20377248
566	Acetylation	ENYGYQHKKEQGEQT HHHCHHCCHHCCCCC	42.34	24489116
573	Phosphorylation	KKEQGEQTPVTRNAE CHHCCCCCCCCCCHH	18.54	23749301
576	Phosphorylation	QGEQTPVTRNAEESF CCCCCCCCCCHHHHC	21.29	24961812
582	Phosphorylation	VTRNAEESFPAASIS CCCCHHHHCCCCEEC	28.21	24961812
587	Phosphorylation	EESFPAASISEGVTT HHHCCCCEECCCCCC	28.84	24909858
589	Phosphorylation	SFPAASISEGVTTAK HCCCCEECCCCCCCC	26.29	24909858
593	Phosphorylation	ASISEGVTTAKPSSN CEECCCCCCCCCCCC	31.71	24961812
594	Phosphorylation	SISEGVTTAKPSSNE EECCCCCCCCCCCCC	30.22	24961812
646	Phosphorylation	AVASTTRTRSPELQD HHHHCCCCCCHHHHH	33.15	22369663
648	Phosphorylation	ASTTRTRSPELQDNL HHCCCCCCHHHHHHH	23.32	22369663
657	Phosphorylation	ELQDNLKSSSSLLQD HHHHHHHCCHHHHCC	38.32	22369663
658	Phosphorylation	LQDNLKSSSSLLQDQ HHHHHHCCHHHHCCC	23.51	22369663
659	Phosphorylation	QDNLKSSSSLLQDQT HHHHHCCHHHHCCCC	31.90	22369663
660	Phosphorylation	DNLKSSSSLLQDQTP HHHHCCHHHHCCCCC	34.74	22369663
666	Phosphorylation	SSLLQDQTPQRQEDA HHHHCCCCCCCCCCC	29.67	22890988
674	Phosphorylation	PQRQEDATDPTTSST CCCCCCCCCCCCCCH	55.63	22369663
677	Phosphorylation	QEDATDPTTSSTNEL CCCCCCCCCCCHHHH	41.96	20377248
678	Phosphorylation	EDATDPTTSSTNELS CCCCCCCCCCHHHHC	26.52	22369663
679	Phosphorylation	DATDPTTSSTNELSA CCCCCCCCCHHHHCC	37.33	22369663
680	Phosphorylation	ATDPTTSSTNELSAA CCCCCCCCHHHHCCC	32.91	22369663
681	Phosphorylation	TDPTTSSTNELSAAE CCCCCCCHHHHCCCC	32.26	22369663
685	Phosphorylation	TSSTNELSAAEPTMV CCCHHHHCCCCCEEE	21.18	24909858
690	Phosphorylation	ELSAAEPTMVTSTHA HHCCCCCEEEEECCC	18.77	22369663
693	Phosphorylation	AAEPTMVTSTHATKT CCCCEEEEECCCCCE	19.65	22369663
694	Phosphorylation	AEPTMVTSTHATKTI CCCEEEEECCCCCEE	13.54	22369663
695	Phosphorylation	EPTMVTSTHATKTIQ CCEEEEECCCCCEEE	13.23	22369663
698	Phosphorylation	MVTSTHATKTIQAQT EEEECCCCCEEECCC	22.55	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MSC3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MSC3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MSC3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
LSP1_YEAST	LSP1	physical	18719252

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MSC3_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390; THR-646; SER-648;SER-658; SER-659; SER-660 AND THR-681, AND MASS SPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-648 AND SER-679, ANDMASS SPECTROMETRY.	17563356 [Abstract]
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151; SER-155 ANDSER-172, AND MASS SPECTROMETRY.	17287358 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-151; SER-155 ANDSER-363, AND MASS SPECTROMETRY.	17330950 [Abstract]
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.	15665377 [Abstract]