LAM6_YEAST - dbPTM
LAM6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAM6_YEAST
UniProt AC Q08001
Protein Name Membrane-anchored lipid-binding protein LAM6 {ECO:0000303|PubMed:26001273}
Gene Name LAM6 {ECO:0000303|PubMed:26001273}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 693
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein . Localizes to intracellular puncta representing endoplasmic reticulum-mitochondrion membrane contact sites (ERMES), nucleus-vacuole junctions (NVJ) and vacuole-mitochondria patches (vCLAM
Protein Description Involved in regulation of various organellar membrane contact sites. [PubMed: 26119743 May be involved in sterol transfer between intracellular membranes]
Protein Sequence MWGDSMRELGDAMDNELNAVKPVVEEGGMDGARKFIKGKSFQKSSTEHMLISPGRDGSVPLNGLKSSPADPHLSDVNSILDNHRGGGETALTSVNNIIMATSTNGDSDGVDGDAKRPSISNCSSRSSFFDTVLSTFSLKSNSQDTVTNEVKNIEVQFASEEANKKFRQMFKPLAPNTRLITDYFCYFHREFPYQGRIYLSNTHLCFNSTVLNWMAKLQIPLNEIKYLDKVTTNSSAISVETVTNRYTFSGFIARDEVFQLITRVWSKENLTNINDVLEVDERVSKKKGISSTPSSIFNNVSTNAYNDFISTTTTEPTSRASYMSENDMLIEEAIRSVDDYMGTPRASPSSSSSSSSSSSSLGSSTTYYCRPVYRLKPNAPFQYEGPFHVQETMDFPYKPEANNEYVLLERQFSVPPGLLFIMMFNEDNPVFELSFLKTQDSSNISHIGTFEKVNKDGQHYREFQYTKQLHFPVGPKSTNCEVAEILLHCDWERYINVLSITRTPNVPSGTSFSTRTRYMFRWDDQGQGCILKISFWVDWNASSWIKPMVESNCKNGQISATKDLVKLVEEFVEKYVELSKEKADTLKPLPSVTSFGSPRKVAAPELTMVQPESKPEAEAEISEIGSDRWRFNWVNIIILVLLVLNLLYLMKLNKKMDKLTNLMTHKDEVVAHATLLDIPAKVQWSRPRRGDVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MWGDSMRELGDA
---CCCHHHHHHHHH		21440633
44PhosphorylationKGKSFQKSSTEHMLI
CCCCCCCCCCCEEEE		20377248
45PhosphorylationGKSFQKSSTEHMLIS
CCCCCCCCCCEEEEC		20377248
46PhosphorylationKSFQKSSTEHMLISP
CCCCCCCCCEEEECC		20377248
52PhosphorylationSTEHMLISPGRDGSV
CCCEEEECCCCCCCC		21440633
58PhosphorylationISPGRDGSVPLNGLK
ECCCCCCCCCCCCCC		24909858
66PhosphorylationVPLNGLKSSPADPHL
CCCCCCCCCCCCCCH		30377154
67PhosphorylationPLNGLKSSPADPHLS
CCCCCCCCCCCCCHH		28889911
78PhosphorylationPHLSDVNSILDNHRG
CCHHHHHHHHHCCCC		25704821
118PhosphorylationDGDAKRPSISNCSSR
CCCCCCCCCCCCCCC		23749301
120PhosphorylationDAKRPSISNCSSRSS
CCCCCCCCCCCCCCH		28889911
123PhosphorylationRPSISNCSSRSSFFD
CCCCCCCCCCCHHHH		17563356
124PhosphorylationPSISNCSSRSSFFDT
CCCCCCCCCCHHHHH		19779198
127PhosphorylationSNCSSRSSFFDTVLS
CCCCCCCHHHHHHHH		19779198
140PhosphorylationLSTFSLKSNSQDTVT
HHHHCCCCCCCCCCH		22369663
142PhosphorylationTFSLKSNSQDTVTNE
HHCCCCCCCCCCHHH		22369663
284PhosphorylationLEVDERVSKKKGISS
HHHHHHHHHHCCCCC		24961812
291PhosphorylationSKKKGISSTPSSIFN
HHHCCCCCCCHHHHC		21440633
295PhosphorylationGISSTPSSIFNNVST
CCCCCCHHHHCCCCC		21440633
324PhosphorylationTSRASYMSENDMLIE
CCCHHHCCHHHHHHH		30377154
336PhosphorylationLIEEAIRSVDDYMGT
HHHHHHHCHHHHCCC		28889911
340PhosphorylationAIRSVDDYMGTPRAS
HHHCHHHHCCCCCCC		22890988
343PhosphorylationSVDDYMGTPRASPSS
CHHHHCCCCCCCCCC		22369663
347PhosphorylationYMGTPRASPSSSSSS
HCCCCCCCCCCCCCC		28889911
350PhosphorylationTPRASPSSSSSSSSS
CCCCCCCCCCCCCCC		28889911
351PhosphorylationPRASPSSSSSSSSSS
CCCCCCCCCCCCCCC		28889911
352PhosphorylationRASPSSSSSSSSSSS
CCCCCCCCCCCCCCC		28889911
353PhosphorylationASPSSSSSSSSSSSS
CCCCCCCCCCCCCCC		28889911
356PhosphorylationSSSSSSSSSSSSLGS
CCCCCCCCCCCCCCC		28889911
585PhosphorylationLSKEKADTLKPLPSV
HCHHHCCCCCCCCCC		22369663
587UbiquitinationKEKADTLKPLPSVTS
HHHCCCCCCCCCCCC		23749301
591PhosphorylationDTLKPLPSVTSFGSP
CCCCCCCCCCCCCCC		22369663
593PhosphorylationLKPLPSVTSFGSPRK
CCCCCCCCCCCCCCE		22369663
594PhosphorylationKPLPSVTSFGSPRKV
CCCCCCCCCCCCCEE		22369663
597PhosphorylationPSVTSFGSPRKVAAP
CCCCCCCCCCEECCC		22369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAM6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAM6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAM6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HS104_YEASTHSP104physical
16554755
EF3A_YEASTYEF3physical
16554755
ARP8_YEASTARP8physical
16554755
TOM71_YEASTTOM71physical
25987606
TOM70_YEASTTOM70physical
25987606
VAC8_YEASTVAC8physical
25987606
GEM1_YEASTGEM1physical
25987606
MDM34_YEASTMDM34physical
25987606
LEU9_YEASTLEU9physical
25987606
NPR1_YEASTNPR1physical
25987606
ERJ5_YEASTERJ5physical
25987606
YBT1_YEASTYBT1physical
25987606
MAM33_YEASTMAM33physical
25987606
PDR10_YEASTPDR10physical
25987606
ERG6_YEASTERG6physical
25987606
KOG1_YEASTKOG1physical
25987606
MNP1_YEASTMNP1physical
25987606
VPH1_YEASTVPH1physical
25987606
MDM10_YEASTMDM10genetic
27708008
GEM1_YEASTGEM1genetic
27708008
IES1_YEASTIES1genetic
27708008
MDM34_YEASTMDM34genetic
27708008
VMA21_YEASTVMA21genetic
27708008
MDM12_YEASTMDM12genetic
27708008
FABD_YEASTMCT1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAM6_YEAST

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Related Literatures of Post-Translational Modification

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