MNP1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MNP1_YEAST
• UniProt AC: P53163
• Protein Name: 54S ribosomal protein L12, mitochondrial
• Gene Name: MNP1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 194
• Subcellular Localization: Mitochondrion . Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner memb
• Protein Description: Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane..
• Protein Sequence: MSLRILAKRSSSIWMKTRVTPALISPITITTRFNSTTTTAPSHKDDVRPVDPKISKIVQDISQLTLLETSSLINELKTVLNIPEISMPMGGFMAGAAGAGAGNVPSSTGEAGSGAEEEAKPEAKTVFTVKLDSFDTKTKAKVIKEVKGLLGLSLVEAKKFVEAAPKVLKENVAKDDAEKIKKTLEDLGAKVSLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LRILAKRSSSIWMKT HHHCCCCCCCCCCCC	27.94	19823750
11	Phosphorylation	RILAKRSSSIWMKTR HHCCCCCCCCCCCCC	29.85	20377248
12	Phosphorylation	ILAKRSSSIWMKTRV HCCCCCCCCCCCCCC	22.86	21440633
34	N-linked_Glycosylation	ITITTRFNSTTTTAP EEEEECCCCCCCCCC	34.85	-
113	Phosphorylation	SSTGEAGSGAEEEAK CCCCCCCCCCCHHCC	41.71	21440633
130	Acetylation	AKTVFTVKLDSFDTK CEEEEEEEECCCCHH	43.44	24489116
137	Acetylation	KLDSFDTKTKAKVIK EECCCCHHHHHHHHH	50.28	24489116
147	Acetylation	AKVIKEVKGLLGLSL HHHHHHHHHHHCCCH	44.95	24489116
158	Acetylation	GLSLVEAKKFVEAAP CCCHHHHHHHHHHHH	32.99	24489116
169	2-Hydroxyisobutyrylation	EAAPKVLKENVAKDD HHHHHHHHHCCCHHH	50.67	-
174	Succinylation	VLKENVAKDDAEKIK HHHHCCCHHHHHHHH	52.43	23954790
182	Acetylation	DDAEKIKKTLEDLGA HHHHHHHHHHHHHCC	62.91	22865919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MNP1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MNP1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MNP1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MNP1_YEAST	MNP1	physical	11967834
BCP1_YEAST	BCP1	physical	18719252

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.