TOM71_YEAST - dbPTM
TOM71_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TOM71_YEAST
UniProt AC P38825
Protein Name Protein TOM71
Gene Name TOM71
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 639
Subcellular Localization Mitochondrion outer membrane
Single-pass membrane protein .
Protein Description Involved in MBF1-mediated mitochondrial morphogenesis..
Protein Sequence MAENSLLRFITKNKVAILATVSAGTAAVGAYVYYQQIKQQQQQQLKGTKDNRRQSEAFAGQNEDEADLKDDGSVVSGSNKRKKKKNKRKRNNKAKSGEGFDYPSLPNGEPDIAQLKGLSPSQRQAYAVQLKNRGNHFFTAKNFNEAIKYYQYAIELDPNEPVFYSNISACYISTGDLEKVIEFTTKALEIKPDHSKALLRRASANESLGNFTDAMFDLSVLSLNGDFDGASIEPMLERNLNKQAMKVLNENLSKDEGRGSQVLPSNTSLASFFGIFDSHLEVSSVNTSSNYDTAYALLSDALQRLYSATDEGYLVANDLLTKSTDMYHSLLSANTVDDPLRENAALALCYTGIFHFLKNNLLDAQVLLQESINLHPTPNSYIFLALTLADKENSQEFFKFFQKAVDLNPEYPPTYYHRGQMYFILQDYKNAKEDFQKAQSLNPENVYPYIQLACLLYKQGKFTESEAFFNETKLKFPTLPEVPTFFAEILTDRGDFDTAIKQYDIAKRLEEVQEKIHVGIGPLIGKATILARQSSQDPTQLDEEKFNAAIKLLTKACELDPRSEQAKIGLAQLKLQMEKIDEAIELFEDSAILARTMDEKLQATTFAEAAKIQKRLRADPIISAKMELTLARYRAKGML
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MAENSLLRFITK
---CCCCHHHHHHHC		21.9319823750
11PhosphorylationNSLLRFITKNKVAIL
CHHHHHHHCCCEEEE		26.3419823750
55PhosphorylationTKDNRRQSEAFAGQN
CCCCHHHHHHHCCCC		29.1322369663
73PhosphorylationADLKDDGSVVSGSNK
CHHCCCCCCCCCCHH		26.7522369663
76PhosphorylationKDDGSVVSGSNKRKK
CCCCCCCCCCHHHHH		34.0622369663
78PhosphorylationDGSVVSGSNKRKKKK
CCCCCCCCHHHHHHC		31.5022890988
96PhosphorylationKRNNKAKSGEGFDYP
HHCCCCCCCCCCCCC		47.1121440633
102PhosphorylationKSGEGFDYPSLPNGE
CCCCCCCCCCCCCCC		7.7724961812
141AcetylationGNHFFTAKNFNEAIK
CCCCEEECCHHHHHH		60.0424489116
196AcetylationEIKPDHSKALLRRAS
HCCCCHHHHHHHHHH		39.3724489116
254UbiquitinationVLNENLSKDEGRGSQ
HHHHCCCCCCCCCCC		64.0723749301
306PhosphorylationSDALQRLYSATDEGY
HHHHHHHHHCCCCCE		9.8427017623
307PhosphorylationDALQRLYSATDEGYL
HHHHHHHHCCCCCEE		29.3227017623
332PhosphorylationDMYHSLLSANTVDDP
HHHHHHHCCCCCCCH		25.4327017623
335PhosphorylationHSLLSANTVDDPLRE
HHHHCCCCCCCHHHH		25.6527017623
403AcetylationEFFKFFQKAVDLNPE
HHHHHHHHHHHCCCC		45.2624489116
461AcetylationCLLYKQGKFTESEAF
HHHHHCCCCCCCHHH		46.7724489116
526UbiquitinationGIGPLIGKATILARQ
CCHHHHCHHHHHHHH		35.0523749301
600UbiquitinationLARTMDEKLQATTFA
HHHHHHHHHHHHCHH		41.4523749301
600AcetylationLARTMDEKLQATTFA
HHHHHHHHHHHHCHH		41.4524489116
611UbiquitinationTTFAEAAKIQKRLRA
HCHHHHHHHHHHHCC		53.3623749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TOM71_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TOM71_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TOM71_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MFB1_YEASTMFB1genetic
18007655
HSP71_YEASTSSA1physical
19581297
HSP82_YEASTHSP82physical
19581297
HSP72_YEASTSSA2physical
22940862
SSB1_YEASTSSB1physical
22940862
G3P3_YEASTTDH3physical
22940862
HSP71_YEASTSSA1physical
22940862
TOM71_YEASTTOM71physical
22940862
DED1_YEASTDED1physical
22940862
PABP_YEASTPAB1physical
22940862
RRP5_YEASTRRP5physical
22940862
EF1A_YEASTTEF2physical
22940862
KPYK1_YEASTCDC19physical
22940862
IDH2_YEASTIDH2physical
22940862
HSP71_YEASTSSA1physical
20823510
DJP1_YEASTDJP1genetic
23959800
APC11_YEASTAPC11genetic
27708008
PDC2_YEASTPDC2genetic
27708008
TYSY_YEASTCDC21genetic
27708008
DED1_YEASTDED1genetic
27708008
UAP1_YEASTQRI1genetic
27708008
KIN28_YEASTKIN28genetic
27708008
DBF4_YEASTDBF4genetic
27708008
GPI11_YEASTGPI11genetic
27708008
BCP1_YEASTBCP1genetic
27708008
GPI13_YEASTGPI13genetic
27708008
RU1C_YEASTYHC1genetic
27708008
SEC65_YEASTSEC65genetic
27708008
RNA1_YEASTRNA1genetic
27708008
TIM23_YEASTTIM23genetic
27708008
TOA1_YEASTTOA1genetic
27708008
MYO2_YEASTMYO2genetic
27708008
TF2B_YEASTSUA7genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TOM71_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55 AND SER-96, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55, AND MASSSPECTROMETRY.

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