MFB1_YEAST - dbPTM
MFB1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MFB1_YEAST
UniProt AC Q04922
Protein Name Mitochondrial F-box protein MFB1
Gene Name MFB1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 465
Subcellular Localization Mitochondrion .
Protein Description
Protein Sequence MTLFSCSVQMPLEERSLTNLPLNLLFRILSHLDMNDLQNIGKTCTLLRMLANENIVYRNAVIGSNGNMWWTKNVLVDVFDVLNFNRKAMKTLNSHNISLVASLRNVQRKYKLGVIDPARKTISYRTNEVESKEKGSVKDLNMDLNEPTEITREQIAHTAILQGMNQFIELNDKAFRTHSADSDDTYIEENNGEIHSLHGLEKNTTFEEDLVKKPPFIPSPTFSNYSRSSTNSVFSSSSPKLLDDDWNNITMDFTKSRDPDYKEMTPTSTESSDSITRLRKSNKVKDKAELFEKLIFRDSRPLKTKKKDNPRLKLSSSLSANDEDFRKIISPPSDILPKVGRRSVSRGYLEEIERHYPDFNGETTNPLAIKRVNSTKIANYEQLIIKENSSNCKGITEKNDENKFQRSHTSPVIELSKPHQRSKLKAVVTDGNKICYRKIELDNPSGSNTNDHVIKRLDANTDFNI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42UbiquitinationNDLQNIGKTCTLLRM
HHHHHHHHHHHHHHH		36.3123749301
57PhosphorylationLANENIVYRNAVIGS
HHCCCEEEEEEEECC		8.3728132839
72UbiquitinationNGNMWWTKNVLVDVF
CCCCCEECCEEEHHH		31.1917644757
87UbiquitinationDVLNFNRKAMKTLNS
HHHCCCHHHHHHHHH		54.6717644757
90UbiquitinationNFNRKAMKTLNSHNI
CCCHHHHHHHHHCCH		55.5117644757
111UbiquitinationRNVQRKYKLGVIDPA
HHHHHHHCCCCCCCC		41.6317644757
120UbiquitinationGVIDPARKTISYRTN
CCCCCCCCEEECCCC		52.9317644757
138UbiquitinationSKEKGSVKDLNMDLN
CCCCCCCCCCCCCCC		59.1923749301
177PhosphorylationLNDKAFRTHSADSDD
HCCHHHHCCCCCCCC		17.4624961812
179PhosphorylationDKAFRTHSADSDDTY
CHHHHCCCCCCCCCE		32.9124961812
182PhosphorylationFRTHSADSDDTYIEE
HHCCCCCCCCCEEEC		36.7824961812
185PhosphorylationHSADSDDTYIEENNG
CCCCCCCCEEECCCC		31.2424961812
186PhosphorylationSADSDDTYIEENNGE
CCCCCCCEEECCCCE		17.2124961812
196PhosphorylationENNGEIHSLHGLEKN
CCCCEEEECCCCCCC		27.9423749301
204PhosphorylationLHGLEKNTTFEEDLV
CCCCCCCCCCCHHHC		43.8828889911
205PhosphorylationHGLEKNTTFEEDLVK
CCCCCCCCCCHHHCC		38.1425752575
219PhosphorylationKKPPFIPSPTFSNYS
CCCCCCCCCCCCCCC		31.5825752575
221PhosphorylationPPFIPSPTFSNYSRS
CCCCCCCCCCCCCCC		43.9924961812
223PhosphorylationFIPSPTFSNYSRSST
CCCCCCCCCCCCCCC		37.0223749301
228PhosphorylationTFSNYSRSSTNSVFS
CCCCCCCCCCCCCCC		35.2622369663
229PhosphorylationFSNYSRSSTNSVFSS
CCCCCCCCCCCCCCC		30.4222369663
230PhosphorylationSNYSRSSTNSVFSSS
CCCCCCCCCCCCCCC		32.5322369663
232PhosphorylationYSRSSTNSVFSSSSP
CCCCCCCCCCCCCCC		25.3222369663
235PhosphorylationSSTNSVFSSSSPKLL
CCCCCCCCCCCCCCC		27.4423749301
236PhosphorylationSTNSVFSSSSPKLLD
CCCCCCCCCCCCCCC		24.3020377248
237PhosphorylationTNSVFSSSSPKLLDD
CCCCCCCCCCCCCCC		49.8422369663
238PhosphorylationNSVFSSSSPKLLDDD
CCCCCCCCCCCCCCC		28.1822369663
261PhosphorylationTKSRDPDYKEMTPTS
HHCCCCCCHHCCCCC		17.7829136822
265PhosphorylationDPDYKEMTPTSTESS
CCCCHHCCCCCCCCH		25.2222369663
267PhosphorylationDYKEMTPTSTESSDS
CCHHCCCCCCCCHHH		38.8322369663
268PhosphorylationYKEMTPTSTESSDSI
CHHCCCCCCCCHHHH		31.2322369663
269PhosphorylationKEMTPTSTESSDSIT
HHCCCCCCCCHHHHH		42.2222369663
271PhosphorylationMTPTSTESSDSITRL
CCCCCCCCHHHHHHH		39.2622369663
272PhosphorylationTPTSTESSDSITRLR
CCCCCCCHHHHHHHH		29.1922369663
274PhosphorylationTSTESSDSITRLRKS
CCCCCHHHHHHHHHC		28.0122369663
276PhosphorylationTESSDSITRLRKSNK
CCCHHHHHHHHHCCC		27.8322369663
283UbiquitinationTRLRKSNKVKDKAEL
HHHHHCCCCCCHHHH		58.7217644757
285UbiquitinationLRKSNKVKDKAELFE
HHHCCCCCCHHHHHH		55.9417644757
287UbiquitinationKSNKVKDKAELFEKL
HCCCCCCHHHHHHHH		37.7317644757
293UbiquitinationDKAELFEKLIFRDSR
CHHHHHHHHHHCCCC		39.2817644757
299PhosphorylationEKLIFRDSRPLKTKK
HHHHHCCCCCCCCCC		31.3827017623
315PhosphorylationDNPRLKLSSSLSAND
CCCCCCCCCCCCCCH		19.1222369663
316PhosphorylationNPRLKLSSSLSANDE
CCCCCCCCCCCCCHH		45.8122369663
317PhosphorylationPRLKLSSSLSANDED
CCCCCCCCCCCCHHH		23.9822369663
319PhosphorylationLKLSSSLSANDEDFR
CCCCCCCCCCHHHHH		27.2922369663
327UbiquitinationANDEDFRKIISPPSD
CCHHHHHHHCCCHHH		44.3717644757
330PhosphorylationEDFRKIISPPSDILP
HHHHHHCCCHHHCCH		33.9429734811
333PhosphorylationRKIISPPSDILPKVG
HHHCCCHHHCCHHHC		40.4421440633
338UbiquitinationPPSDILPKVGRRSVS
CHHHCCHHHCCCCCH		54.6017644757
343PhosphorylationLPKVGRRSVSRGYLE
CHHHCCCCCHHHHHH		24.0822369663
345PhosphorylationKVGRRSVSRGYLEEI
HHCCCCCHHHHHHHH		22.6423749301
348PhosphorylationRRSVSRGYLEEIERH
CCCCHHHHHHHHHHH		15.1622369663
393UbiquitinationKENSSNCKGITEKND
ECCCCCCCCCCCCCC		58.5617644757
398UbiquitinationNCKGITEKNDENKFQ
CCCCCCCCCCCCHHC		62.1317644757
403UbiquitinationTEKNDENKFQRSHTS
CCCCCCCHHCCCCCC		40.6017644757
409PhosphorylationNKFQRSHTSPVIELS
CHHCCCCCCCEEECC		35.6520377248
410PhosphorylationKFQRSHTSPVIELSK
HHCCCCCCCEEECCC		16.2523749301
417UbiquitinationSPVIELSKPHQRSKL
CCEEECCCCCCHHHC		60.1717644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MFB1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MFB1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MFB1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YHS2_YEASTCIA2physical
11805837
SKP1_YEASTSKP1physical
11805837
MDM30_YEASTMDM30genetic
16790494
SKP1_YEASTSKP1physical
16790494
TOM71_YEASTTOM71physical
18007655
TOM70_YEASTTOM70physical
18007655
VPS10_YEASTPEP1genetic
20093466
MBA1_YEASTMBA1genetic
20093466
ODPB_YEASTPDB1genetic
20093466
SWC5_YEASTSWC5genetic
20093466
ILV6_YEASTILV6genetic
20093466
NPP1_YEASTNPP1genetic
20093466
THRC_YEASTTHR4genetic
20093466
YIH1_YEASTYIH1genetic
20093466
GLT1_YEASTGLT1genetic
20093466
BCS1_YEASTBCS1genetic
20093466
SHE9_YEASTSHE9genetic
20093466
COX23_YEASTCOX23genetic
20093466
SDHX_YEASTYJL045Wgenetic
20093466
CBT1_YEASTCBT1genetic
20093466
MMR1_YEASTMMR1genetic
20093466
SMA2_YEASTSMA2genetic
20093466
MSS1_YEASTMSS1genetic
20093466
TOM70_YEASTTOM70genetic
20093466
TOM7_YEASTTOM7genetic
20093466
GLO4_YEASTGLO4genetic
20093466
WHI5_YEASTWHI5genetic
20093466
HAP5_YEASTHAP5genetic
20093466
ATG29_YEASTATG29genetic
20093466
NACB1_YEASTEGD1genetic
20093466
MDM36_YEASTMDM36genetic
20093466
QCR2_YEASTQCR2genetic
20093466
CND2_YEASTBRN1genetic
27708008
CDK1_YEASTCDC28genetic
27708008
RSC8_YEASTRSC8genetic
27708008
RPN12_YEASTRPN12genetic
27708008
SWC4_YEASTSWC4genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
SEC22_YEASTSEC22genetic
27708008
TAD3_YEASTTAD3genetic
27708008
CLP1_YEASTCLP1genetic
27708008
IF6_YEASTTIF6genetic
27708008
MTU1_YEASTSLM3genetic
27708008
MRM2_YEASTMRM2genetic
27708008
CDC27_YEASTCDC27genetic
27708008
TECR_YEASTTSC13genetic
27708008
PRP11_YEASTPRP11genetic
27708008
CDC13_YEASTCDC13genetic
27708008
RPB7_YEASTRPB7genetic
27708008
CDC14_YEASTCDC14genetic
27708008
CDC11_YEASTCDC11genetic
27708008
PRP24_YEASTPRP24genetic
27708008
PROF_YEASTPFY1genetic
27708008
IPL1_YEASTIPL1genetic
27708008
PSB5_YEASTPRE2genetic
27708008
ALK2_YEASTALK2genetic
27708008
YMC2_YEASTYMC2genetic
27708008
MBA1_YEASTMBA1genetic
27708008
ODPB_YEASTPDB1genetic
27708008
ILV6_YEASTILV6genetic
27708008
IMG2_YEASTIMG2genetic
27708008
BCS1_YEASTBCS1genetic
27708008
SHE9_YEASTSHE9genetic
27708008
RTR1_YEASTRTR1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
COX23_YEASTCOX23genetic
27708008
DAL81_YEASTDAL81genetic
27708008
CBT1_YEASTCBT1genetic
27708008
ATP10_YEASTATP10genetic
27708008
MAC1_YEASTMAC1genetic
27708008
TOM7_YEASTTOM7genetic
27708008
CY1_YEASTCYT1genetic
27708008
NACB1_YEASTEGD1genetic
27708008
ELOC_YEASTELC1genetic
27708008
MDM36_YEASTMDM36genetic
27708008
QCR2_YEASTQCR2genetic
27708008
NUM1_YEASTNUM1genetic
26839174
MMR1_YEASTMMR1genetic
26839174
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MFB1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219; SER-238 ANDSER-319, AND MASS SPECTROMETRY.

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