NPP1_YEAST - dbPTM
NPP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NPP1_YEAST
UniProt AC P25353
Protein Name Ectonucleotide pyrophosphatase/phosphodiesterase 1
Gene Name NPP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 742
Subcellular Localization Membrane
Single-pass type II membrane protein .
Protein Description Mediates extracellular nucleotide derived phosphate hydrolysis along with NPP2 and PHO5..
Protein Sequence MELQNDLESLDNELNDFSEDPFRDDFITDEDAVRSGWRSAWTRMKYWFYKNRLKWTNNPIVIGDAKDSRDGSNFRRGIPLYELDANGQPIDTELVDENELSFGTGFHSKVPFKIIFRTLFGSLVFAIFLILMINIAKPHHSTRVLSHFGSPEFDPYVKYFNGTHEFFPLTIVISLDGFHPSLISKRNTPFLHDLYELKYDGGMNITSTPFMVPSFPTETFPNHWTLVTGQYPIHHGIVSNVFWDPDLNEEFHPGVLDPRIWNNNDTEPIWQTVQSAFDGDIPFKAATHMWPGSDVNYTKYNEEKLQPEHKNPIARERTPFYFDEFNAKEPLSQKLSKIIEYVDMSTLNERPQLILGYVPNVDAFGHKHGYPSESEYYYEDFTETLGEVDTFLKQLVESLQERNLTSFTNLVIVSDHGMSDIVVPSNVIIWEDLLDEKLRKDYVSHAYLEGPMMAISLKDSGNINEVYHNLKTSIDEDKYTVYVNGNFPKEWNFNDGKNHHMASIWIVPEPGYAVMKKEQLKKVAKGDHKDKNEDNVFTIGSHGYDNNAIDMRSVFIGMGPYFPQGYIEPFQNTEIYNLLCDICGVAEKDRNSNDGTGMLMNQLREPQSSEEVEIEDDFDYLVSKFGEFSTYNIIWGGYPEETEQDNVDNDNDDNDDGNTDEIAAMPSSSLTIKLEMTTSIPSATETLLGETSPSSRSSSSSSIQASATASTVGDWLQDIINDAKDLIDDIIDSIDDLVDSDT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationELQNDLESLDNELND
CHHHHHHHHHHHHHH		48.6028889911
66UbiquitinationPIVIGDAKDSRDGSN
CEEECCCCCCCCCCC		62.0623749301
118PhosphorylationPFKIIFRTLFGSLVF
CHHHHHHHHHHHHHH		18.7123749301
122PhosphorylationIFRTLFGSLVFAIFL
HHHHHHHHHHHHHHH		17.6423749301
137UbiquitinationILMINIAKPHHSTRV
HHHHHHHCCCCCHHH		40.8823749301
161N-linked_GlycosylationDPYVKYFNGTHEFFP
CCCCEECCCCCCCCE		51.90-
204N-linked_GlycosylationLKYDGGMNITSTPFM
EEECCCCCCCCCCEE		37.35-
264N-linked_GlycosylationDPRIWNNNDTEPIWQ
CCCCCCCCCCCCHHH		55.13-
296N-linked_GlycosylationMWPGSDVNYTKYNEE
CCCCCCCCHHHCCHH		43.69-
328AcetylationYFDEFNAKEPLSQKL
CCCCCCCCCCHHHHH		62.0524489116
403N-linked_GlycosylationVESLQERNLTSFTNL
HHHHHHCCCCCCEEE		47.09-
442PhosphorylationDEKLRKDYVSHAYLE
CHHHHHHHCCHHHHC		13.5927017623
444PhosphorylationKLRKDYVSHAYLEGP
HHHHHHCCHHHHCCC		9.0027017623
447PhosphorylationKDYVSHAYLEGPMMA
HHHCCHHHHCCCEEE		10.4028889911
456PhosphorylationEGPMMAISLKDSGNI
CCCEEEEEEECCCCH		21.5928889911
679PhosphorylationIKLEMTTSIPSATET
EEEEEECCCCCCHHH		24.2819779198
695PhosphorylationLGETSPSSRSSSSSS
CCCCCCCCCCCCCCC		39.3019779198
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NPP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NPP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NPP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DCC1_YEASTDCC1genetic
19269370
KCC4_YEASTKCC4genetic
19269370
SSD1_YEASTSSD1genetic
19269370
VAC14_YEASTVAC14genetic
19269370
ARPC3_YEASTARC18genetic
27708008
ELO3_YEASTELO3genetic
27708008
UTP5_YEASTUTP5genetic
27708008
ACT_YEASTACT1genetic
27708008
STT3_YEASTSTT3genetic
27708008
PRP43_YEASTPRP43genetic
27708008
MED6_YEASTMED6genetic
27708008
BOS1_YEASTBOS1genetic
27708008
RNA1_YEASTRNA1genetic
27708008
NUF2_YEASTNUF2genetic
27708008
EI2BG_YEASTGCD1genetic
27708008
ARL1_YEASTARL1genetic
27708008
RV167_YEASTRVS167genetic
27708008
ATG1_YEASTATG1genetic
27708008
RTF1_YEASTRTF1genetic
27708008
SDO1L_YEASTRTC3genetic
27708008
KNS1_YEASTKNS1genetic
27708008
FPS1_YEASTFPS1genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
ENV10_YEASTENV10genetic
27708008
FKS1_YEASTFKS1genetic
27708008
GSF2_YEASTGSF2genetic
27708008
SKY1_YEASTSKY1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
FATE1_HUMANFATE1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NPP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9, AND MASSSPECTROMETRY.

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