| UniProt ID | FPS1_YEAST | |
|---|---|---|
| UniProt AC | P23900 | |
| Protein Name | Glycerol uptake/efflux facilitator protein | |
| Gene Name | FPS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 669 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Channel protein for glycerol. Has a role in both glycerol influx and efflux. Plays a role in osmoregulation: under osmotic stress the channel is apparently closed to allow accumulation of glycerol in the cell under hyperosmotic conditions.. | |
| Protein Sequence | MSNPQKALNDFLSSESVHTHDSSRKQSNKQSSDEGRSSSQPSHHHSGGTNNNNNNNNNNNNSNNNNNGNDGGNDDDYDYEMQDYRPSPQSARPTPTYVPQYSVESGTAFPIQEVIPSAYINTQDINHKDNGPPSASSNRAFRPRGQTTVSANVLNIEDFYKNADDAHTIPESHLSRRRSRSRATSNAGHSANTGATNGRTTGAQTNMESNESPRNVPIMVKPKTLYQNPQTPTVLPSTYHPINKWSSVKNTYLKEFLAEFMGTMVMIIFGSAVVCQVNVAGKIQQDNFNVALDNLNVTGSSAETIDAMKSLTSLVSSVAGGTFDDVALGWAAAVVMGYFCAGGSAISGAHLNPSITLANLVYRGFPLKKVPYYFAGQLIGAFTGALILFIWYKRVLQEAYSDWWMNESVAGMFCVFPKPYLSSGRQFFSEFLCGAMLQAGTFALTDPYTCLSSDVFPLMMFILIFIINASMAYQTGTAMNLARDLGPRLALYAVGFDHKMLWVHHHHFFWVPMVGPFIGALMGGLVYDVCIYQGHESPVNWSLPVYKEMIMRAWFRRPGWKKRNRARRTSDLSDFSYNNDDDEEFGERMALQKTKTKSSISDNENEAGEKKVQFKSVQRGKRTFGGIPTILEEEDSIETASLGATTTDSIGLSDTSSEDSHYGNAKKVT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 | Phosphorylation | KALNDFLSSESVHTH HHHHHHHHCCCCCCC | 31.86 | 21440633 | |
| 14 | Phosphorylation | ALNDFLSSESVHTHD HHHHHHHCCCCCCCC | 35.72 | 24961812 | |
| 16 | Phosphorylation | NDFLSSESVHTHDSS HHHHHCCCCCCCCCC | 22.58 | 19684113 | |
| 19 | Phosphorylation | LSSESVHTHDSSRKQ HHCCCCCCCCCCCCC | 25.81 | 28152593 | |
| 22 | Phosphorylation | ESVHTHDSSRKQSNK CCCCCCCCCCCCCCC | 25.16 | 28152593 | |
| 23 | Phosphorylation | SVHTHDSSRKQSNKQ CCCCCCCCCCCCCCC | 49.94 | 19684113 | |
| 134 | Phosphorylation | HKDNGPPSASSNRAF CCCCCCCCCCCCCCC | 43.87 | 21440633 | |
| 136 | Phosphorylation | DNGPPSASSNRAFRP CCCCCCCCCCCCCCC | 32.27 | 23749301 | |
| 137 | Phosphorylation | NGPPSASSNRAFRPR CCCCCCCCCCCCCCC | 30.01 | 28889911 | |
| 147 | Phosphorylation | AFRPRGQTTVSANVL CCCCCCCCEEEEEEE | 31.80 | 24909858 | |
| 148 | Phosphorylation | FRPRGQTTVSANVLN CCCCCCCEEEEEEEC | 12.46 | 17330950 | |
| 150 | Phosphorylation | PRGQTTVSANVLNIE CCCCCEEEEEEECHH | 16.42 | 17330950 | |
| 161 | Ubiquitination | LNIEDFYKNADDAHT ECHHHHHHCCCCCCC | 45.73 | 17644757 | |
| 168 | Phosphorylation | KNADDAHTIPESHLS HCCCCCCCCCHHHHH | 39.69 | 17330950 | |
| 172 | Phosphorylation | DAHTIPESHLSRRRS CCCCCCHHHHHHHHH | 25.11 | 19684113 | |
| 175 | Phosphorylation | TIPESHLSRRRSRSR CCCHHHHHHHHHHHH | 20.51 | 17330950 | |
| 181 | Phosphorylation | LSRRRSRSRATSNAG HHHHHHHHHHHCCCC | 27.75 | 28889911 | |
| 184 | Phosphorylation | RRSRSRATSNAGHSA HHHHHHHHCCCCCCC | 22.77 | 17563356 | |
| 185 | Phosphorylation | RSRSRATSNAGHSAN HHHHHHHCCCCCCCC | 24.57 | 23749301 | |
| 190 | Phosphorylation | ATSNAGHSANTGATN HHCCCCCCCCCCCCC | 23.46 | 17563356 | |
| 193 | Phosphorylation | NAGHSANTGATNGRT CCCCCCCCCCCCCCC | 28.10 | 28889911 | |
| 200 | Phosphorylation | TGATNGRTTGAQTNM CCCCCCCCCCCCCCC | 30.86 | 22369663 | |
| 201 | Phosphorylation | GATNGRTTGAQTNME CCCCCCCCCCCCCCC | 29.20 | 22369663 | |
| 205 | Phosphorylation | GRTTGAQTNMESNES CCCCCCCCCCCCCCC | 35.68 | 22369663 | |
| 209 | Phosphorylation | GAQTNMESNESPRNV CCCCCCCCCCCCCCC | 34.82 | 22369663 | |
| 212 | Phosphorylation | TNMESNESPRNVPIM CCCCCCCCCCCCCEE | 33.15 | 22369663 | |
| 221 | Ubiquitination | RNVPIMVKPKTLYQN CCCCEEECCCCCCCC | 24.34 | 23749301 | |
| 224 | Phosphorylation | PIMVKPKTLYQNPQT CEEECCCCCCCCCCC | 38.94 | 24961812 | |
| 226 | Phosphorylation | MVKPKTLYQNPQTPT EECCCCCCCCCCCCC | 16.10 | 24961812 | |
| 231 | Phosphorylation | TLYQNPQTPTVLPST CCCCCCCCCCCCCCC | 23.37 | 17620418 | |
| 537 | Phosphorylation | CIYQGHESPVNWSLP EEECCCCCCCCCCCH | 28.59 | 28889911 | |
| 569 | Phosphorylation | KRNRARRTSDLSDFS HCCCCCCCCCCCCCC | 22.50 | 21082442 | |
| 570 | Phosphorylation | RNRARRTSDLSDFSY CCCCCCCCCCCCCCC | 34.44 | 17330950 | |
| 573 | Phosphorylation | ARRTSDLSDFSYNND CCCCCCCCCCCCCCC | 41.42 | 17330950 | |
| 576 | Phosphorylation | TSDLSDFSYNNDDDE CCCCCCCCCCCCCCH | 31.76 | 17330950 | |
| 577 | Phosphorylation | SDLSDFSYNNDDDEE CCCCCCCCCCCCCHH | 20.27 | 19684113 | |
| 593 | Ubiquitination | GERMALQKTKTKSSI HHHHHHHHCCCCCCC | 53.49 | 23749301 | |
| 596 | Phosphorylation | MALQKTKTKSSISDN HHHHHCCCCCCCCCC | 41.20 | 19823750 | |
| 597 | Ubiquitination | ALQKTKTKSSISDNE HHHHCCCCCCCCCCC | 43.70 | 23749301 | |
| 598 | Phosphorylation | LQKTKTKSSISDNEN HHHCCCCCCCCCCCC | 37.83 | 23749301 | |
| 599 | Phosphorylation | QKTKTKSSISDNENE HHCCCCCCCCCCCCC | 27.89 | 23749301 | |
| 601 | Phosphorylation | TKTKSSISDNENEAG CCCCCCCCCCCCCHH | 36.01 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FPS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FPS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FPS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212; THR-569; SER-599AND SER-601, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-184; SER-190 ANDSER-570, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150; THR-168 ANDSER-212, AND MASS SPECTROMETRY. | |
