CYC1_YEAST - dbPTM
CYC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CYC1_YEAST
UniProt AC P00044
Protein Name Cytochrome c iso-1
Gene Name CYC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 109
Subcellular Localization Mitochondrion intermembrane space . Loosely associated with the inner membrane..
Protein Description Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain..
Protein Sequence MTEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGRHSGQAEGYSYTDANIKKNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLITYLKKACE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10UbiquitinationEFKAGSAKKGATLFK
CCCCCCCCCCCEEEE		54.13-
78"N6,N6,N6-trimethyllysine"SEYLTNPKKYIPGTK
HHHHCCHHHCCCCCC		61.35-
78MethylationSEYLTNPKKYIPGTK
HHHHCCHHHCCCCCC		61.3511880631
79"N6,N6,N6-trimethyllysine"EYLTNPKKYIPGTKM
HHHCCHHHCCCCCCC		50.06-
79MethylationEYLTNPKKYIPGTKM
HHHCCHHHCCCCCCC		50.0610821864
95AcetylationFGGLKKEKDRNDLIT
CCCCCCCCCHHHHHH		71.5124489116
102PhosphorylationKDRNDLITYLKKACE
CCHHHHHHHHHHHHC		30.0522369663
103PhosphorylationDRNDLITYLKKACE-
CHHHHHHHHHHHHC-		14.9922369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CYC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
79KMethylation

10821864
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CYC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TF2B_YEASTSUA7genetic
8692696
T2FA_YEASTTFG1genetic
7724527
CYC7_YEASTCYC7genetic
12522138
CYC1_YEASTCYC1physical
16893189
CCPR_YEASTCCP1physical
16893189
RPB1_YEASTRPO21genetic
8264591
NAM7_YEASTNAM7genetic
10733586
NCBP2_YEASTCBC2genetic
10733586
NCBP1_YEASTSTO1genetic
10733586
PDE2_YEASTPDE2genetic
21623372
SUR1_YEASTSUR1genetic
21623372
CY1_YEASTCYT1genetic
21623372
C1TM_YEASTMIS1genetic
21623372
INP51_YEASTINP51genetic
21623372
FUMH_YEASTFUM1genetic
21623372
ATPA_YEASTATP1genetic
21623372
QCR1_YEASTCOR1physical
12206886
CY1_YEASTCYT1physical
12206886
CCPR_YEASTCCP1physical
11900539
PIN4_YEASTPIN4genetic
21987634
CSG2_YEASTCSG2genetic
21987634
SWC5_YEASTSWC5genetic
21987634
POP4_YEASTPOP4genetic
21987634
TPS2_YEASTTPS2genetic
21987634
IPK1_YEASTIPK1genetic
21987634
GPA2_YEASTGPA2genetic
21987634
ERG4_YEASTERG4genetic
21987634
YKG3_YEASTYKL063Cgenetic
21987634
YET1_YEASTYET1genetic
21987634
GPT2_YEASTGPT2genetic
21987634
ERG3_YEASTERG3genetic
21987634
ARPC3_YEASTARC18genetic
21987634
CYK2_YEASTHOF1genetic
21987634
VPS27_YEASTVPS27genetic
21987634
IRA2_YEASTIRA2genetic
21987634
TIM18_YEASTTIM18genetic
21987634
KAPB_YEASTTPK2genetic
21987634
YME1_YEASTYME1genetic
21987634
CYC7_YEASTCYC7genetic
23897805
COX14_YEASTCOX14genetic
23897805
NCBP1_YEASTSTO1genetic
25041160
NCBP2_YEASTCBC2genetic
25041160
NAM7_YEASTNAM7genetic
25041160
NMD2_YEASTNMD2genetic
25041160
UPF3_YEASTUPF3genetic
25041160
CRD1_YEASTCRD1genetic
27708008
APA2_YEASTAPA2genetic
27708008
ITC1_YEASTITC1genetic
27708008
MOT3_YEASTMOT3genetic
27708008
HDA3_YEASTHDA3genetic
27708008
IPYR_YEASTIPP1genetic
27708008
MED8_YEASTMED8genetic
27708008
TIM22_YEASTTIM22genetic
27708008
ACT_YEASTACT1genetic
27708008
COPB2_YEASTSEC27genetic
27708008
NUP57_YEASTNUP57genetic
27708008
MED6_YEASTMED6genetic
27708008
SEC65_YEASTSEC65genetic
27708008
SEC23_YEASTSEC23genetic
27708008
SDS24_YEASTSDS24genetic
27708008
SWC5_YEASTSWC5genetic
27708008
RV161_YEASTRVS161genetic
27708008
S2538_YEASTYDL119Cgenetic
27708008
PAL1_YEASTPAL1genetic
27708008
RIM15_YEASTRIM15genetic
27708008
SWP82_YEASTSWP82genetic
27708008
CSK2B_YEASTCKB1genetic
27708008
VPS29_YEASTVPS29genetic
27708008
RT25_YEASTRSM25genetic
27708008
IXR1_YEASTIXR1genetic
27708008
MCR1_YEASTMCR1genetic
27708008
TOF2_YEASTTOF2genetic
27708008
SHB17_YEASTSHB17genetic
27708008
YL283_YEASTYLR283Wgenetic
27708008
COX8_YEASTCOX8genetic
27708008
DATI_YEASTDAT1genetic
27708008
RIM13_YEASTRIM13genetic
27708008
VHS3_YEASTVHS3genetic
27708008
PALA_YEASTRIM20genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
VTS1_YEASTVTS1genetic
27708008
YP014_YEASTYPL014Wgenetic
27708008
YP071_YEASTYPL071Cgenetic
27708008
ROX1_YEASTROX1genetic
27708008
SPEE_YEASTSPE3genetic
27708008
RL36A_YEASTRPL36Agenetic
29158977
DOM34_YEASTDOM34genetic
29158977
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CYC1_YEAST

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Related Literatures of Post-Translational Modification
Methylation
ReferencePubMed
"Cytochrome c methyltransferase, Ctm1p, of yeast.";
Polevoda B., Martzen M.R., Das B., Phizicky E.M., Sherman F.;
J. Biol. Chem. 275:20508-20513(2000).
Cited for: METHYLATION AT LYS-78, AND MUTAGENESIS OF LYS-78.

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