dbPTM

QCR1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	QCR1_YEAST
UniProt AC	P07256
Protein Name	Cytochrome b-c1 complex subunit 1, mitochondrial
Gene Name	COR1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	457
Subcellular Localization	Mitochondrion inner membrane .
Protein Description	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. COR1 may mediate formation of the complex between cytochromes c and c1..
Protein Sequence	MLRTVTSKTVSNQFKRSLATAVATPKAEVTQLSNGIVVATEHNPSAHTASVGVVFGSGAANENPYNNGVSNLWKNIFLSKENSAVAAKEGLALSSNISRDFQSYIVSSLPGSTDKSLDFLNQSFIQQKANLLSSSNFEATKKSVLKQVQDFEENDHPNRVLEHLHSTAFQNTPLSLPTRGTLESLENLVVADLESFANNHFLNSNAVVVGTGNIKHEDLVNSIESKNLSLQTGTKPVLKKKAAFLGSEVRLRDDTLPKAWISLAVEGEPVNSPNYFVAKLAAQIFGSYNAFEPASRLQGIKLLDNIQEYQLCDNFNHFSLSYKDSGLWGFSTATRNVTMIDDLIHFTLKQWNRLTISVTDTEVERAKSLLKLQLGQLYESGNPVNDANLLGAEVLIKGSKLSLGEAFKKIDAITVKDVKAWAGKRLWDQDIAIAGTGQIEGLLDYMRIRSDMSMMRW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MLRTVTSKTVS ----CCCCCCCHHHH	24.95	30377154
6	Phosphorylation	--MLRTVTSKTVSNQ --CCCCCCCHHHHHH	24.72	30377154
9	Phosphorylation	LRTVTSKTVSNQFKR CCCCCCHHHHHHHHH	29.00	30377154
11	Phosphorylation	TVTSKTVSNQFKRSL CCCCHHHHHHHHHHH	30.10	30377154
20	Phosphorylation	QFKRSLATAVATPKA HHHHHHHHHHCCCCH	27.27	28889911
24	Phosphorylation	SLATAVATPKAEVTQ HHHHHHCCCCHHHEE	20.80	27214570
80	2-Hydroxyisobutyrylation	WKNIFLSKENSAVAA HHHHHHCCCCHHHHH	64.16	-
80	Acetylation	WKNIFLSKENSAVAA HHHHHHCCCCHHHHH	64.16	24489116
94	Phosphorylation	AKEGLALSSNISRDF HHHHHCCCCCCCHHH	18.74	27214570
133	Phosphorylation	QQKANLLSSSNFEAT HHHHHHHCCCCHHHH	34.58	27214570
134	Phosphorylation	QKANLLSSSNFEATK HHHHHHCCCCHHHHH	29.30	27214570
135	Phosphorylation	KANLLSSSNFEATKK HHHHHCCCCHHHHHH	42.01	23749301
140	Phosphorylation	SSSNFEATKKSVLKQ CCCCHHHHHHHHHHH	31.63	28889911
141	2-Hydroxyisobutyrylation	SSNFEATKKSVLKQV CCCHHHHHHHHHHHH	50.53	-
146	Acetylation	ATKKSVLKQVQDFEE HHHHHHHHHHHHHCC	46.39	24489116
166	Phosphorylation	RVLEHLHSTAFQNTP HHHHHHHHCCCCCCC	27.99	22369663
167	Phosphorylation	VLEHLHSTAFQNTPL HHHHHHHCCCCCCCC	22.27	22369663
172	Phosphorylation	HSTAFQNTPLSLPTR HHCCCCCCCCCCCCC	18.15	22369663
175	Phosphorylation	AFQNTPLSLPTRGTL CCCCCCCCCCCCCHH	33.24	22369663
178	Phosphorylation	NTPLSLPTRGTLESL CCCCCCCCCCHHHHH	47.20	22369663
235	Acetylation	LSLQTGTKPVLKKKA CCCCCCCCCHHHHHH	34.18	24489116
247	Phosphorylation	KKAAFLGSEVRLRDD HHHHHHCCEEEECCC	34.76	27214570
272	Phosphorylation	VEGEPVNSPNYFVAK ECCCCCCCCCHHHHH	18.11	27214570
287	Phosphorylation	LAAQIFGSYNAFEPA HHHHHHCCCCCCCCH	12.40	24909858
357	Phosphorylation	QWNRLTISVTDTEVE HHCCEEEEEEHHHHH	17.46	26447709
359	Phosphorylation	NRLTISVTDTEVERA CCEEEEEEHHHHHHH	30.34	26447709
408	Acetylation	LSLGEAFKKIDAITV CCHHHHHHHCCEEEH	56.73	24489116
408	Succinylation	LSLGEAFKKIDAITV CCHHHHHHHCCEEEH	56.73	23954790
409	2-Hydroxyisobutyrylation	SLGEAFKKIDAITVK CHHHHHHHCCEEEHH	39.09	-
416	Acetylation	KIDAITVKDVKAWAG HCCEEEHHHHHHHCC	48.42	24489116
419	2-Hydroxyisobutyrylation	AITVKDVKAWAGKRL EEEHHHHHHHCCCCC	48.63	-
424	2-Hydroxyisobutyrylation	DVKAWAGKRLWDQDI HHHHHCCCCCCCCCE	36.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of QCR1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of QCR1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of QCR1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
QCR2_YEAST	QCR2	physical	11805826
QCR2_YEAST	QCR2	physical	16554755
QCR2_YEAST	QCR2	physical	16429126
QCR2_YEAST	QCR2	physical	11283351
QCR2_YEAST	QCR2	physical	17113393
COX2_YEAST	COX2	physical	17113393
COX4_YEAST	COX4	physical	17113393
TIM17_YEAST	TIM17	physical	17113393
TIM23_YEAST	TIM23	physical	17113393
TIM21_YEAST	TIM21	physical	17113393
QCR6_YEAST	QCR6	physical	17882259
COX2_YEAST	COX2	physical	17882259
COX4_YEAST	COX4	physical	17882259
SHY1_YEAST	SHY1	physical	17882259
UCRI_YEAST	RIP1	physical	17882259
CY1_YEAST	CYT1	physical	17882259
COX14_YEAST	COX14	physical	17882259
TIM23_YEAST	TIM23	physical	18070913
TIM17_YEAST	TIM17	physical	18070913
TIM14_YEAST	PAM18	physical	18070913
TIM16_YEAST	PAM16	physical	18070913
CY1_YEAST	CYT1	physical	20876281
COX4_YEAST	COX4	physical	20876281
SHY1_YEAST	SHY1	physical	20876281
COA3_YEAST	COA3	physical	20876281
QCR1_YEAST	COR1	physical	20826334
QCR2_YEAST	QCR2	physical	22342701
UCRI_YEAST	RIP1	physical	22342701
ADT2_YEAST	PET9	physical	22342701
CY1_YEAST	CYT1	physical	22342701
QCR7_YEAST	QCR7	physical	22342701
COX5A_YEAST	COX5A	physical	22342701
COX4_YEAST	COX4	physical	22342701
COX13_YEAST	COX13	physical	22342701
COX2_YEAST	COX2	physical	22342701
COX6_YEAST	COX6	physical	22342701
FMP25_YEAST	FMP25	physical	22342701
RCF2_YEAST	RCF2	physical	22342701
MAM33_YEAST	MAM33	physical	22342701
COX5B_YEAST	COX5B	physical	22342701
QCR8_YEAST	QCR8	physical	22342701
PET54_YEAST	PET54	physical	22342701
COX9_YEAST	COX9	physical	22342701
MDM38_YEAST	MDM38	physical	22342701
MCR1_YEAST	MCR1	physical	22342701
AIM36_YEAST	AIM36	physical	22342701
YIH7_YEAST	YIL077C	physical	22342701
COX12_YEAST	COX12	physical	22342701
ATPO_YEAST	ATP5	physical	22342701
RCF1_YEAST	RCF1	physical	22342701
MSS18_YEAST	MSS18	physical	22342701
COX7_YEAST	COX7	physical	22342701
COX11_YEAST	COX11	physical	22342701
OMS1_YEAST	OMS1	physical	22342701
CBP3_YEAST	CBP3	physical	22342701
RM28_YEAST	MRPL28	physical	22342701
YB255_YEAST	YBR255C-A	physical	22342701
MG101_YEAST	MGM101	physical	22342701
COX1_YEAST	COX1	physical	22342701
MGR3L_YEAST	YKL133C	physical	22342701
TIM50_YEAST	TIM50	physical	22342701
YLH47_YEAST	YLH47	physical	22342701
COX15_YEAST	COX15	physical	22342701
MDJ1_YEAST	MDJ1	physical	22342701
RM01_YEAST	MRPL1	physical	22342701
YD19A_YEAST	COX26	physical	22342701
RT12_YEAST	MRPS12	physical	22342701
FMP52_YEAST	FMP52	physical	22342701
QCR9_YEAST	QCR9	physical	22342701
CBP4_YEAST	CBP4	physical	22342701
RS16A_YEAST	RPS16B	physical	22342701
RS16B_YEAST	RPS16B	physical	22342701
TIM21_YEAST	TIM21	physical	22342701
COX14_YEAST	COX14	physical	22342701
RM02_YEAST	MRP7	physical	22342701
COX16_YEAST	COX16	physical	22342701
QCR6_YEAST	QCR6	physical	22342701
CYB_YEAST	COB	physical	22342701
YHM2_YEAST	YHM2	physical	22342701
RT13_YEAST	MRP13	physical	22342701
SHY1_YEAST	SHY1	physical	22342701
COX8_YEAST	COX8	physical	22342701
TIM14_YEAST	PAM18	physical	22342701
GEP3_YEAST	GEP3	physical	22342701
AIM19_YEAST	AIM19	physical	22342701
YP010_YEAST	YPR010C-A	physical	22342701
RM04_YEAST	MRPL4	physical	22342701
RM34_YEAST	YDR115W	physical	22342701
RT51_YEAST	MRP51	physical	22342701
YNM2_YEAST	YNL122C	physical	22342701
MIA40_YEAST	MIA40	physical	22342701
MS116_YEAST	MSS116	physical	22342701
ATPK_YEAST	ATP17	physical	22342701
RML2_YEAST	RML2	physical	22342701
RN49_YEAST	MRPL49	physical	22342701
AIM39_YEAST	AIM39	physical	22342701
LIPA_YEAST	LIP5	physical	22342701
COA3_YEAST	COA3	physical	22342701
PT100_YEAST	PET100	physical	22342701
MGR2_YEAST	MGR2	physical	22613836
TIM17_YEAST	TIM17	physical	22613836
TIM50_YEAST	TIM50	physical	22613836
UCRI_YEAST	RIP1	physical	22613836
QCR8_YEAST	QCR8	physical	22613836
COX13_YEAST	COX13	physical	22613836
COX1_YEAST	COX1	physical	22613836
TIM21_YEAST	TIM21	physical	22613836
TIM23_YEAST	TIM23	physical	22613836
COX2_YEAST	COX2	physical	24928273
UCRI_YEAST	RIP1	physical	24928273
COX2_YEAST	COX2	physical	27662906
UCRI_YEAST	RIP1	physical	27662906
YB255_YEAST	YBR255C-A	physical	27662906
COX1_YEAST	COX1	physical	27030670
COX14_YEAST	COX14	physical	27030670
UCRI_YEAST	RIP1	physical	27030670
QCR8_YEAST	QCR8	physical	27030670
RCF2_YEAST	RCF2	physical	27030670
IME1_YEAST	IME1	genetic	29301906

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of QCR1_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-140, AND MASSSPECTROMETRY.	18407956 [Abstract]