YLH47_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YLH47_YEAST
• UniProt AC: Q06493
• Protein Name: LETM1 domain-containing protein YLH47, mitochondrial
• Gene Name: YLH47
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 454
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein .
• Protein Description: Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation..
• Protein Sequence: MLKYRSLPIKRAIHHPAPGITPISPRIMVSRLRVIPSFNLKFNRWNSSVPESSKKELKTTDGNQESASKVSPVKEKEKVPFKVKMQKALRHYWDGSKLLGLEIKISSKLLMKSAAGYPLTRRENLQLKRTTQDIVRLVPFAAFLIIPFAELLLPFALKLFPNLLPSTYESSKKRENKLENLRNTRKLMSEIIKNNKSHFKPNNISEEQKALFNRFYTHVRATGVPESRQQLIEVARLFTDDTVLDNVTRPYLIALAKYMNLQPFGTDVMLRYRIRYKMLELKKDDLSIYYEDAEQLSLSELKTACASRGIRSVDVEPSVLYSNLRLWLNMRLKDKIPSTLLIMATAYNYGNVQSKESLYDALCDVLIGIPDELYHEVKVNVVKEDEASAKQKLKQLREQEEIMKEEEQQEENAIVSVKDELSLDDQDKNIDAAAPDVKPHDTKPIGEAAAIKEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
200	Acetylation	KNNKSHFKPNNISEE HHCCCCCCCCCCCHH	41.22	22865919
290	Phosphorylation	KDDLSIYYEDAEQLS CCCEEEECCCHHHCC	12.98	19779198
307	Phosphorylation	ELKTACASRGIRSVD HHHHHHHHCCCCCCC	30.81	19779198
383	Succinylation	EVKVNVVKEDEASAK CCCCEEECCCHHHHH	55.98	23954790
443	Acetylation	DVKPHDTKPIGEAAA CCCCCCCCCCCHHHH	40.47	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RSP5	P39940	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YLH47_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YLH47_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RT06_YEAST	MRP17	physical	16476776
RT02_YEAST	MRP2	physical	16476776
RT21_YEAST	MRP21	physical	16476776
RT04_YEAST	MRP4	physical	16476776
RT51_YEAST	MRP51	physical	16476776
RT16_YEAST	MRPS16	physical	16476776
RT17_YEAST	MRPS17	physical	16476776
RT18_YEAST	MRPS18	physical	16476776
RT28_YEAST	MRPS28	physical	16476776
RT35_YEAST	MRPS35	physical	16476776
RT05_YEAST	MRPS5	physical	16476776
RT08_YEAST	MRPS8	physical	16476776
RT09_YEAST	MRPS9	physical	16476776
NAM9_YEAST	NAM9	physical	16476776
RTPT_YEAST	PET123	physical	16476776
RT10_YEAST	RSM10	physical	16476776
RSM18_YEAST	RSM18	physical	16476776
RT22_YEAST	RSM22	physical	16476776
RT23_YEAST	RSM23	physical	16476776
RT24_YEAST	RSM24	physical	16476776
RT27_YEAST	RSM27	physical	16476776
RMAR_YEAST	VAR1	physical	16476776
IMG1_YEAST	IMG1	physical	16476776
IMG2_YEAST	IMG2	physical	16476776
RM41_YEAST	MRP20	physical	16476776
RM49_YEAST	MRP49	physical	16476776
RM01_YEAST	MRPL1	physical	16476776
RM11_YEAST	MRPL11	physical	16476776
RM13_YEAST	MRPL13	physical	16476776
RM15_YEAST	MRPL15	physical	16476776
RM17_YEAST	MRPL17	physical	16476776
RM20_YEAST	MRPL20	physical	16476776
RM24_YEAST	MRPL24	physical	16476776
RM25_YEAST	MRPL25	physical	16476776
RM28_YEAST	MRPL28	physical	16476776
RM03_YEAST	MRPL3	physical	16476776
RM35_YEAST	MRPL35	physical	16476776
RM36_YEAST	MRPL36	physical	16476776
RM04_YEAST	MRPL4	physical	16476776
RN49_YEAST	MRPL49	physical	16476776
RM51_YEAST	MRPL51	physical	16476776
RM08_YEAST	MRPL8	physical	16476776
RM09_YEAST	MRPL9	physical	16476776
RL4P_YEAST	YML6	physical	16476776
RM10_YEAST	MRPL10	physical	16476776
MDM10_YEAST	MDM10	genetic	21987634
GEM1_YEAST	GEM1	genetic	21987634
LONM_YEAST	PIM1	genetic	21987634
UGO1_YEAST	UGO1	genetic	21987634
MDM34_YEAST	MDM34	genetic	21987634
GEP4_YEAST	GEP4	genetic	21987634
ABF2_YEAST	ABF2	genetic	21987634
MDM12_YEAST	MDM12	genetic	21987634
YME1_YEAST	YME1	genetic	21987634
RTC6_YEAST	RTC6	genetic	27708008
TPS1_YEAST	TPS1	genetic	27708008
SLX5_YEAST	SLX5	genetic	27708008
ATG9_YEAST	ATG9	genetic	27708008
SAC3_YEAST	SAC3	genetic	27708008
CEM1_YEAST	CEM1	genetic	27708008
MDM34_YEAST	MDM34	genetic	27708008
LPLA_YEAST	AIM22	genetic	27708008
MMM1_YEAST	MMM1	genetic	27708008
MDM12_YEAST	MDM12	genetic	27708008
RFM1_YEAST	RFM1	genetic	27708008
MGR2_YEAST	MGR2	genetic	27708008
HSP7F_YEAST	SSE1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.