| UniProt ID | MIA40_YEAST | |
|---|---|---|
| UniProt AC | P36046 | |
| Protein Name | Mitochondrial intermembrane space import and assembly protein 40 | |
| Gene Name | MIA40 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 403 | |
| Subcellular Localization |
Mitochondrion inner membrane Single-pass type II membrane protein Intermembrane side . |
|
| Protein Description | Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced MIA40 is reoxidized by FAD-linked sulfhydryl oxidase ERV1.. | |
| Protein Sequence | MLRNLVVRNACRNRPSIQVARGLCRHQTRRLMASSPQFGRNSNQEKTAGFIMGILSMAGALYFIAPNRKPLFASRKVESDKTAEEELSSGGEQSPENEDDNNSKSDENGDDNDSKNDETEAGPQLGGDKIGASKVAEDGELVVLAEEDNKSSEDKDTDESKVSTKDDEQSNEDNATANNQKDENISSENSEENTSDKTLDNNAGSSEKKDPEHSDDEKSQQGQSDDKTTTEDNNGEEESSKKTVSDSENSAKQSESSDEEKEELRKQEEKQMGPTEEEVQHEGAYNPDTGEINWDCPCLGGMAHGPCGEEFKSAFSCFVYSEAEPKGIDCVEKFQHMQDCFRKYPEHYAEQLKETSDDEEPQDKVKVNTIESAPNVSSAKENAAKKAEQSDVKKEPLNEESKP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 35 | Phosphorylation | TRRLMASSPQFGRNS HHHHHHCCCCCCCCC | 17.12 | 28132839 | |
| 82 | Phosphorylation | RKVESDKTAEEELSS CCCCCCCCHHHHHHC | 44.27 | 21126336 | |
| 88 | Phosphorylation | KTAEEELSSGGEQSP CCHHHHHHCCCCCCC | 30.16 | 21551504 | |
| 89 | Phosphorylation | TAEEELSSGGEQSPE CHHHHHHCCCCCCCC | 64.54 | 21551504 | |
| 103 | Phosphorylation | ENEDDNNSKSDENGD CCCCCCCCCCCCCCC | 39.53 | 25521595 | |
| 105 | Phosphorylation | EDDNNSKSDENGDDN CCCCCCCCCCCCCCC | 50.40 | 22369663 | |
| 114 | Phosphorylation | ENGDDNDSKNDETEA CCCCCCCCCCCCCCC | 39.34 | 25521595 | |
| 119 | Phosphorylation | NDSKNDETEAGPQLG CCCCCCCCCCCCCCC | 33.72 | 22369663 | |
| 151 | Phosphorylation | LAEEDNKSSEDKDTD EEECCCCCCCCCCCC | 45.26 | 25521595 | |
| 157 | Phosphorylation | KSSEDKDTDESKVST CCCCCCCCCHHHCCC | 47.62 | 20377248 | |
| 163 | Phosphorylation | DTDESKVSTKDDEQS CCCHHHCCCCCHHHC | 33.21 | 21551504 | |
| 164 | Phosphorylation | TDESKVSTKDDEQSN CCHHHCCCCCHHHCC | 41.29 | 21551504 | |
| 170 | Phosphorylation | STKDDEQSNEDNATA CCCCHHHCCCCCCCC | 39.89 | 28889911 | |
| 176 | Phosphorylation | QSNEDNATANNQKDE HCCCCCCCCCHHHHC | 35.85 | 28889911 | |
| 190 | Phosphorylation | ENISSENSEENTSDK CCCCCCCCCCCCCCC | 42.08 | 27017623 | |
| 194 | Phosphorylation | SENSEENTSDKTLDN CCCCCCCCCCCCCCC | 41.40 | 27017623 | |
| 198 | Phosphorylation | EENTSDKTLDNNAGS CCCCCCCCCCCCCCC | 44.31 | 20377248 | |
| 214 | Phosphorylation | EKKDPEHSDDEKSQQ CCCCCCCCCHHHHHC | 45.13 | 21440633 | |
| 228 | Phosphorylation | QGQSDDKTTTEDNNG CCCCCCCCCCCCCCC | 46.04 | 21551504 | |
| 229 | Phosphorylation | GQSDDKTTTEDNNGE CCCCCCCCCCCCCCC | 33.65 | 21551504 | |
| 239 | Phosphorylation | DNNGEEESSKKTVSD CCCCCCHHHCCCCCC | 51.22 | 21551504 | |
| 240 | Phosphorylation | NNGEEESSKKTVSDS CCCCCHHHCCCCCCH | 41.26 | 21551504 | |
| 243 | Phosphorylation | EEESSKKTVSDSENS CCHHHCCCCCCHHHH | 29.04 | 21551504 | |
| 245 | Phosphorylation | ESSKKTVSDSENSAK HHHCCCCCCHHHHHH | 40.42 | 27214570 | |
| 247 | Phosphorylation | SKKTVSDSENSAKQS HCCCCCCHHHHHHHC | 31.04 | 28889911 | |
| 254 | Phosphorylation | SENSAKQSESSDEEK HHHHHHHCCCCHHHH | 38.45 | 19823750 | |
| 256 | Phosphorylation | NSAKQSESSDEEKEE HHHHHCCCCHHHHHH | 48.62 | 19823750 | |
| 257 | Phosphorylation | SAKQSESSDEEKEEL HHHHCCCCHHHHHHH | 45.02 | 19823750 | |
| 344 | Phosphorylation | MQDCFRKYPEHYAEQ HHHHHHHCHHHHHHH | 15.03 | 19823750 | |
| 348 | Phosphorylation | FRKYPEHYAEQLKET HHHCHHHHHHHHHHC | 15.35 | 19823750 | |
| 355 | Phosphorylation | YAEQLKETSDDEEPQ HHHHHHHCCCCCCCC | 35.55 | 22890988 | |
| 356 | Phosphorylation | AEQLKETSDDEEPQD HHHHHHCCCCCCCCC | 44.12 | 22890988 | |
| 372 | Phosphorylation | VKVNTIESAPNVSSA CCCEECCCCCCHHHH | 45.21 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MIA40_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MIA40_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MIA40_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, AND MASSSPECTROMETRY. | |
