TIM12_YEAST - dbPTM
TIM12_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TIM12_YEAST
UniProt AC P32830
Protein Name Mitochondrial import inner membrane translocase subunit TIM12
Gene Name TIM12
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 109
Subcellular Localization Mitochondrion inner membrane
Peripheral membrane protein . Mitochondrion intermembrane space .
Protein Description Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force. In the TIM22 complex, it acts as a docking point for the soluble TIM9-TIM10 heterohexamer that guides the target proteins in transit through the aqueous mitochondrial intermembrane space..
Protein Sequence MSFFLNSLRGNQEVSQEKLDVAGVQFDAMCSTFNNILSTCLEKCIPHEGFGEPDLTKGEQCCIDRCVAKMHYSNRLIGGFVQTRGFGPENQLRHYSRFVAKEIADDSKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSFFLNSLR
------CCHHHHHHC
25.3822814378

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TIM12_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TIM12_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TIM12_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TIM10_YEASTTIM10physical
9495346
TIM22_YEASTTIM22physical
9495346
TIM18_YEASTTIM18physical
10648604
TIM22_YEASTTIM22physical
11509656
TIM54_YEASTTIM54physical
11509656
TIM54_YEASTTIM54physical
10648604
SPT7_YEASTSPT7genetic
12923659
TIM9_YEASTTIM9genetic
9822593
TIM12_YEASTTIM12physical
17627602
TIM9_YEASTTIM9physical
17627602
CYB2_YEASTCYB2genetic
20026652
MIA40_YEASTMIA40physical
18421298
SLK19_YEASTSLK19physical
22940862
MIA40_YEASTMIA40physical
22918950

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TIM12_YEAST

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Related Literatures of Post-Translational Modification

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